Abstract：
:In the present study, temporal changes of voltage-gated Ca(2+) channel (VGCC) immunoreactivities were evaluated in the gerbil hippocampus following ischemia. P/Q-type VGCC immunoreactivity was elevated in the hippocampus in the 3 h post-ischemic group. In the 30 min post-ischemic group, N-type VGCC immunoreactivity began to increase only in the CA1 region. L-type (alpha1C) VGCC immunoreactivity was significantly increased in the 12 h post-ischemic group. L-type (alpha1D) VGCC immunoreactivity began to increase in the CA1 region in the 30 min post-ischemic group and peaked in the 12 h post-ischemic group. These findings suggest that the altered VGCC immunoreactivities following ischemia may play an important role in the ischemic neuronal injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Park SK,An SJ,Hwang IK,Suh JG,Oh YS,Won MH,Kang TCdoi
10.1016/s0006-8993(03)02283-2subject
Has Abstractpub_date
2003-04-25 00:00:00pages
87-96issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899303022832journal_volume
970pub_type
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