Abstract：
:We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists on habenular Fos expression. Rats were injected with various doses of the selective D2 agonist quinpirole (0, 0.62 or 2.5 mg/kg) either alone or in combination with various doses of the selective full D1 agonist A-77636 (0, 0.75 or 3.0 mg/kg). The selective agonists, by themselves, induced only small increases in Fos-like immunoreactivity within the lateral habenula, but combinations of the two drugs resulted in a very robust response. These findings indicate that D1 and D2 receptor agonists interact to induce Fos expression within the habenula and that the nature of this interaction differs from that reported in the striatum and the globus pallidus.
journal_name
Brain Resjournal_title
Brain researchauthors
Wirtshafter D,Krebs JCdoi
10.1016/s0006-8993(96)01353-4subject
Has Abstractpub_date
1997-03-07 00:00:00pages
245-50issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01353-4journal_volume
750pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Rats with hippocampal dialysis probes were treated with DL-fenfluramine (FEN), fluoxetine, or FEN with fluoxetine pre-treatment. FEN (12.5 mg/kg) increased extracellular serotonin (5-HT) from 0.4 +/- 0.04 to 25.2 +/- 4.16 pg/10 microliters. Fluoxetine (10.0 mg/kg) increased extracellular 5-HT levels from 0.4 +/- 0.05 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91249-e
更新日期：1992-07-10 00:00:00
abstract：:The urethrogenital (UG) reflex is a spinal sexual reflex which is tonically inhibited in the intact male rat by neurons in the nucleus paragigantocellularis (nPGi). The medial preoptic area of the hypothalamus (MPOA) is involved in the activation of male sexual behavior. The present study examines the effect of hypoth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90638-6
更新日期：1994-02-28 00:00:00
abstract：:Surgical microscopy and electrophysiological techniques were used to standardize the nomenclature for the pudendal nerve and sacral plexus according to their somatic axonal composition in the male rat. We conclude that the pudendal nerve is the segment running from the L6-S1 trunk to the sacral plexus, carrying effere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00408-3
更新日期：1997-07-25 00:00:00
abstract：:In recent years, we have carried out several studies on brainstem mechanisms associated with pain modulation. Of particular interest has been the region of the nucleus tractus solitarius (NTS) at the level of the area postrema (AP) in the dorsomedial medulla. This region has been found to be rich in opiate receptors a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91362-8
更新日期：1983-07-18 00:00:00
abstract：:To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01361-x
更新日期：1999-05-15 00:00:00
abstract：:This study shows that the axons of some raphespinal sympathoinhibitory neurons projecting to the third thoracic spinal segment emit branches in the third-fourth cervical spinal segments of cats. This was demonstrated by using time-controlled collision of neuronal action potentials initiated by stimuli applied at these...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91417-5
更新日期：1988-02-16 00:00:00
abstract：:alpha(1)-Adrenoceptors are concentrated in the locus coeruleus (LC) where they appear to regulate various active behaviors but have been difficult to stimulate effectively. The present study examined the behavioral, pharmacological and neural effects of possible stimulation of these receptors with 6-fluoronorepinephri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.049
更新日期：2009-09-29 00:00:00
abstract：:We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91089-b
更新日期：1993-07-23 00:00:00
abstract：:We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00414-l
更新日期：1995-07-03 00:00:00
abstract：:The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90537-2
更新日期：1985-03-11 00:00:00
abstract：:Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.016
更新日期：2005-07-27 00:00:00
abstract：:The localization of a GTP-binding protein (G(o)) in the cerebellar and cerebral cortex and hippocampus of the normal and reeler mutant mouse was immunohistochemically examined using affinity-purified antibody raised against the alpha subunit of G(o). Although the general distribution pattern of G(o)-immunoreactive pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91704-v
更新日期：1993-01-22 00:00:00
abstract：:Microinjection of the indirect GABAA antagonist, picrotoxin, or the mu opioid agonist, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO), into the ventral pallidum and substantia innominata (VP/SI) increases locomotor activity in rats. The VP/SI has direct and indirect projections to the region of the ventral mesencephalon containi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91005-l
更新日期：1991-02-22 00:00:00
abstract：:Tissue damage induces acute pain but also long-term central modifications that can affect the behavioral and neuronal responses to a second painful stimulus. To study the effects of female gonadal hormones on the responses to repetition of a nociceptive stimulus, we subjected adult female rats to the formalin test. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.089
更新日期：2006-08-23 00:00:00
abstract：:The distribution of hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) immunoreactivities in the cat brainstem was examined using immunohistochemical techniques. Hcrt-1- and hcrt-2-positive fibers with varicosities were detected in almost all brainstem regions. However, no hcrt-1- or hcrt-2-immunoreactive neuronal somata...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.004
更新日期：2004-01-09 00:00:00
abstract：:The occurrence of hypoxia-ischemia (HI) during early fetal or neonatal stages of an individual leads to the damaging of immature neurons resulting in behavioral and psychological dysfunctions, such as motor or learning disabilities, cerebral palsy, epilepsy or even death. No effective treatment is currently available ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03094-9
更新日期：2002-09-27 00:00:00
abstract：:Adhesion molecules on the endothelial surface of the blood-brain barrier (BBB) play an important role in the pathogenesis of many encephalopathies, including multiple sclerosis (MS) and cerebral malaria (CM). The expression of four surface molecules of relevance to MS and CM on the immortalized human umbilical vein en...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01436-5
更新日期：1999-06-05 00:00:00
abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.058
更新日期：2007-01-12 00:00:00
abstract：:Synaptic potentials evoked in the medial amygdala (m-AMG) neurons were studied in in vitro slice preparations obtained from normal and olfactory bulbectomized rats. Local stimulation induced a sequence of responses: a fast EPSP, a fast IPSP and a slow EPSP. The fast EPSP was suppressed by kynurenic acid (KYN) at a con...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91743-z
更新日期：1990-11-05 00:00:00
abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.092
更新日期：2007-12-14 00:00:00
abstract：:Alpha-synuclein is a brain presynaptic protein that is linked to familiar early onset Parkinson's disease and it is also a major component of Lewy bodies in sporadic Parkinson's disease and other neurodegenerative disorders. Alpha-synuclein expression increases in substantia nigra of both MPTP-treated rodents and non-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02422-8
更新日期：2002-05-10 00:00:00
abstract：:Auditory working memory (WM) is the cognitive faculty that allows us to actively hold and manipulate sounds in mind over short periods of time. We develop here a particular perspective on WM for non-verbal, auditory objects as well as for time based on the consideration of possible parallels to visual WM. In vision, t...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.01.044
更新日期：2016-06-01 00:00:00
abstract：:We examined the responsiveness of rat vestibular ganglion neurons (VGNs) to exogenous neurotrophic factors, BDNF, NT-3, and GDNF, during postnatal development in dissociated cultures. VGNs were obtained from postnatal days (P) 1, 3, 7, and 14. After two days in culture, the survival of VGNs in control cultures without...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.058
更新日期：2011-08-23 00:00:00
abstract：:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90284-5
更新日期：1981-08-24 00:00:00
abstract：:Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.076
更新日期：2005-04-08 00:00:00
abstract：:"Dystrophic' mice of the 129/ReJ-Dy strain have a genetic defect affecting Schwann cell proliferation. Spinal nerve roots of these animals contain myelinated and unmyelinated axons in addition to groups of large "amyelinated' axons. In affected regions of the spinal roots, myelinated axons are missing their myelin she...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91116-1
更新日期：1981-11-09 00:00:00
abstract：:Heterotopic transplantations of brain vesicles of a quail embryo into a chick embryo were carried out in order to elucidate if CNS anlagen have plasticity in differentiation at the 7-10 somite stage. Quail cells are distinguished from chick cells due to the difference in nuclear morphology. The prosencephalon did not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90231-y
更新日期：1990-03-12 00:00:00
abstract：:The localization of serotonergic, various peptidergic and possibly cholinergic neurons in the medullary raphe nuclei that project to the lumbosacral spinal cord have been studied using a retrograde transport method combined with immunocytochemical and histochemical techniques. Spinally projecting neurons stained for s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90079-3
更新日期：1983-12-12 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:Small iontophoretic application of wheat-germ-agglutinin conjugated to horseradish peroxidase, was used to simultaneously observe, in the rat, the afferent and the efferent connections of the cuneiformis nucleus (Cnf), in the same animal. The results demonstrate that the main Cnf afferent connections originate from: (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90449-6
更新日期：1989-06-19 00:00:00
