Abstract：
:The distribution of hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) immunoreactivities in the cat brainstem was examined using immunohistochemical techniques. Hcrt-1- and hcrt-2-positive fibers with varicosities were detected in almost all brainstem regions. However, no hcrt-1- or hcrt-2-immunoreactive neuronal somata were observed in the cat brainstem. Both hcrt-1- and hcrt-2-labeled fibers exhibited different densities in distinct regions of the brainstem. In most brainstem regions, the intensity of hcrt-1 immunoreactivity was higher than that of hcrt-2 immunoreactivity. The highest densities of hcrt-1- and hcrt-2-positive fibers were found in the nucleus raphe dorsalis (RD), the laterodorsal tegmental nucleus (LDT) and the locus coeruleus (LC), suggesting an important role for these peptides in functions related to sleep-wake behavior.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang JH,Sampogna S,Morales FR,Chase MHdoi
10.1016/j.brainres.2003.10.004subject
Has Abstractpub_date
2004-01-09 00:00:00pages
205-17issue
2eissn
0006-8993issn
1872-6240pii
S0006899303038381journal_volume
995pub_type
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