Abstract：
:Systemic effects of anesthesia on the dynamics of the apnea-induced Blood Oxygen Level Dependent (BOLD) signal is still not clear. In the present study, the dynamics of the fMRI-BOLD signal and blood flow using laser Doppler flowmetry (LDF) was studied in rats in response to apnea. Two anesthetics namely pentobarbital and urethane, hypothesized to have distinct effects on the mean arterial blood pressure (MAP) were used. During normoxic baseline conditions, MAP decreased in response to apnea in rats anesthetized with pentobarbital but increased with urethane. However, MAP did not change significantly in response to apnea during hyperoxic or hypercapnic baseline conditions with both anesthetics. LDF increased in response to apnea during normoxia, hyperoxia or hypercapnia and was influenced by MAP during normoxia. Apnea-induced BOLD signal dynamics was similar with both anesthetics, dominated by an alteration in arterial blood oxygenation and independent of changes in MAP. Our results suggest that anesthesia-dependent MAP change modulates the apnea-induced cerebral blood flow (CBF) response but has a minimal effect on the fMRI-BOLD signal probably due to uncoupling of CBF and oxygen consumption.
journal_name
Brain Resjournal_title
Brain researchauthors
Kannurpatti SS,Biswal BBdoi
10.1016/j.brainres.2004.02.076subject
Has Abstractpub_date
2004-06-18 00:00:00pages
141-7issue
2eissn
0006-8993issn
1872-6240pii
S0006899304003804journal_volume
1011pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidative stress response. Superfluous oxidation of DJ-1 at cysteine residue 106 (C106), an inactive form of DJ-1, was observed in PD patients. DJ-1-binding compound B, which ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146641
更新日期：2020-02-15 00:00:00
abstract：:Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91335-x
更新日期：1991-06-07 00:00:00
abstract：:The aim of this study was to evaluate the effects of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the developing brain. Thirty-seven newborn piglets were divided randomly into four groups: normothermic control (NC, n=9); hypothermic control (HC, n=7); normotherm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03186-9
更新日期：2001-12-20 00:00:00
abstract：:In teleosts, the fasciculus medialis tractus optici departs the optic tract and follows an aberrant path towards the midbrain tectum. To determine the retinal origin of the fascicle, horseradish peroxidase was injected into localized lesions of either the optic nerve or the retina. The fasciculus medialis axons of adu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90082-4
更新日期：1985-07-01 00:00:00
abstract：:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.013
更新日期：2004-06-04 00:00:00
abstract：:Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death. Activation of N-methyl-D-aspartate (NM...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00323-x
更新日期：1996-06-17 00:00:00
abstract：:Transependymal absorption of cerebrospinal fluid (CSF) in hydrocephalus is suggested by periventricular edema, but the necessary bulk flow of interstitial fluid (ISF) has not been found. We performed ventriculocisternal perfusions in adult cats using CSF with the extracellular marker [3H]sucrose. CSF pressure was main...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90616-3
更新日期：1982-01-28 00:00:00
abstract：:To investigate the role of the amygdala in central regulation of pancreatic exocrine secretion, the effects of electrolytic lesions on pancreatic secretion were studied in rats. Small bilateral electrolytic lesions in amygdaloid body restricted to basolateral, medial and central nuclei were produced. Eight days after ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90770-x
更新日期：1985-08-05 00:00:00
abstract：:Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91127-7
更新日期：1983-03-28 00:00:00
abstract：:Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.007
更新日期：2008-01-23 00:00:00
abstract：:The amount of myelin and its protein composition was studied in hypothyroid rats during the first 30 days after birth. Although the brain weight was 92% of that in the controls, the yield of myelin in hypothyroid animals was only 60% of that in controls. The protein and glycoprotein ocmposition of the isolated myelin ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90764-7
更新日期：1975-02-14 00:00:00
abstract：:Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.027
更新日期：2011-03-25 00:00:00
abstract：:Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.049
更新日期：2009-06-01 00:00:00
abstract：:Understanding the structural and functional development of neurons in networks has a high impact to estimate the potentials for restorative therapies. Neurons derived from the human NT2 cell line (hNT) formed networks with a clustered neuritic architecture in vitro, whereas primary dissociated embryonic rat cortical n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.076
更新日期：2004-08-20 00:00:00
abstract：:We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00580-5
更新日期：1997-08-22 00:00:00
abstract：:Rarely do we encounter a single odorant in our environment. Perception of odours, therefore, usually depends on the reception and neural processing of many components. However, little is known about how and where odour mixtures are processed. Evidence is presented here that suppression of one odour by another, a commo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90419-7
更新日期：1987-11-17 00:00:00
abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90007-5
更新日期：1977-07-01 00:00:00
abstract：:Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The endocannabinoid, anandamide (AEA), fails to release dynorphin A. The synthetic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01908-3
更新日期：1999-11-27 00:00:00
abstract：:Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02938-9
更新日期：2001-11-02 00:00:00
abstract：:One hundred and four visual units of the (ventral) lateral geniculate nucleus (GL) of chicks (Gallus domesticus) were studied with extracellular microelectrodes. Most were extremely responsive to moving targets even at low speeds (0.1 degrees/sec). They were classified as follows. (1) movement-sensitive units with uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90823-0
更新日期：1979-05-11 00:00:00
abstract：:Opiates modulate pain perception at a number of different levels within the central nervous system and the importance of synergistic spinal and supraspinal influences have been well documented. In the present study we demonstrate synergistic interactions between the periaqueductal gray and locus coeruleus. Administere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90772-n
更新日期：1991-09-06 00:00:00
abstract：:Noradrenergic and dopaminergic regulation of thyrotropin (TSH) secretion was investigated in adult male Wistar rats. TSH secretion displayed a circadian variation with peak serum TSH levels at 10.00 h. The alpha 2-adrenoceptor agonist, clonidine (250 micrograms/kg, i.p.), was found to cause an enhancement of serum TSH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91378-3
更新日期：1987-02-24 00:00:00
abstract：:We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.034
更新日期：2006-08-09 00:00:00
abstract：:Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91596-4
更新日期：1987-12-01 00:00:00
abstract：:The characteristics of dopamine adenylate cyclase in the rat striatum were first studied on homogenates of fresh tissues. In the assay conditions used, dopamine (10(-4) M) stimulated the enzyme activity by 250%. This effect was completely blocked by fluphenazine (10(-5) M; Ki=9X10(-9) M) and by phentolamine (10(-5) M;...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90228-6
更新日期：1976-05-07 00:00:00
abstract：:The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90647-8
更新日期：1976-03-05 00:00:00
abstract：:We sought to characterize regional heterogeneity of astrocytes using adrenergic receptor sites as cellular markers. Primary cultures made from 6 regions of neonatal rat brain consisted almost exclusively of astrocytes. Membranes from astrocytes cultured 1-3 weeks were prepared for radioligand binding assays of beta- a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91027-e
更新日期：1990-05-28 00:00:00
abstract：:This study examined the effects of stria terminalis (ST) lesions on glucocorticoid-induced modulation of memory formation for inhibitory avoidance training and spatial learning in a water maze. Systemic (s.c.) posttraining injections of the glucocorticoid receptor agonist dexamethasone (0.3 or 1.0 mg/kg) enhanced memo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01305-9
更新日期：1996-02-19 00:00:00
abstract：:The effects of induced L9 activity on gill motor neuron L7's ability to elicit a gill withdrawal response were studied. It was found that L9 was a modulator of L7's effectiveness to elicit gill movements. Following L9 activity, L7's ability to elicit a gill withdrawal response was significantly potentiated by up to 24...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90350-0
更新日期：1979-03-16 00:00:00
abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02086-8
更新日期：2001-04-06 00:00:00
