Abstract：
:The aim of this study was to evaluate the effects of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the developing brain. Thirty-seven newborn piglets were divided randomly into four groups: normothermic control (NC, n=9); hypothermic control (HC, n=7); normothermic bilirubin infusion (NB, n=11); and hypothermic bilirubin infusion (HB, n=10) groups. In bilirubin infusion groups (NB and HB), a loading dose of bilirubin (35 mg/kg) was given over 5 min, followed by a continuous infusion (25 mg/kg/h) for 4 h. The control groups (NC, HC) received a bilirubin-free buffer solution. Sulfadimethoxine was administered to animals in all experimental groups. Rectal temperature was maintained between 38.0 and 39.0 degrees C in normothermic groups, and between 34.0 and 35.0 degrees C in hypothermic groups for 4 h after the start of bilirubin infusion. The final blood and brain bilirubin concentrations in the bilirubin infusion groups (NB and HB) were not significantly different. Decreased cerebral cortical cell membrane Na(+),K(+)-ATPase activity and increased lipid peroxidation products observed in the NB group, indicative of bilirubin-induced brain damage, were significantly attenuated in the HB group. Hypothermia also significantly improved the bilirubin-induced reduction in brain ATP and phosphocreatine levels and increase in blood and brain lactate levels. In summary, hypothermia significantly attenuated the bilirubin-induced alterations in brain cell membrane function and energy metabolism in the newborn piglet. These findings suggest the possibility that hypothermia could be a good neuroprotective therapeutic modality in neonatal bilirubin encephalopathy.
journal_name
Brain Resjournal_title
Brain researchauthors
Park WS,Chang YS,Chung SH,Seo DW,Hong SH,Lee Mdoi
10.1016/s0006-8993(01)03186-9subject
Has Abstractpub_date
2001-12-20 00:00:00pages
276-81issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)03186-9journal_volume
922pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Electrical stimulation of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate recurrent inhibition in cells in the nucleus of the solitary tract (NTS, the first central relay in the gustatory system). Here, we explored the relationship between inhibitory circuits and the br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.069
更新日期：2009-06-12 00:00:00
abstract：:The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90395-2
更新日期：1988-11-01 00:00:00
abstract：:The intracellular pH, 7.54 +/- 0.03 (mean +/- S.D., n = 15), determined with the Neutral red method, of the hippocampal brain slice preparation under baseline incubation conditions is considerably more alkaline than the bath buffer pH. Neutralization by amiloride suggests that the alkalinity was due to Na+/H+ exchange...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00512-4
更新日期：1996-08-26 00:00:00
abstract：:Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91639-i
更新日期：1991-01-25 00:00:00
abstract：:Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90085-8
更新日期：1983-03-01 00:00:00
abstract：:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.032
更新日期：2005-05-31 00:00:00
abstract：:Norepinephrine (NE), acting on brain adrenoceptors, plays an important role in barrel field neuronal activity and plasticity. For this reason, the distribution of alpha 1- and alpha 2-adrenoceptors in the somatosensory cortex barrel field was studied by autoradiographic techniques in rats undergoing plastic change or ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90005-8
更新日期：1993-09-24 00:00:00
abstract：:We used triple-labeling immunohistochemistry in rat midbrain sections to identify dopaminergic neurons that contain either one or both of the calcium-binding proteins, calretinin (CR) and calbindin-D28k (CB). Midbrain dopaminergic neurons were immunohistochemically labeled for tyrosine hydroxylase (TH), CR, and CB. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01950-2
更新日期：1999-10-30 00:00:00
abstract：UNLABELLED:The hypothesis that the lower midbrain, specifically in and around the retrorubral field (RRF) and/or rubrospinal tract (rs), contains a tonic inhibitory mechanism on non-shivering thermogenesis (NST) was examined in urethane-anesthetized rats. It has been proposed that removal of the tonic inhibitory mechan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01532-2
更新日期：1999-07-03 00:00:00
abstract：:Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well known and popular herbal medicine used worldwide. Among more than 30 ginsenosides, the active ingredients of ginseng, ginsenosides Rb1 and Rg1 are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. In our study, p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.030
更新日期：2004-09-17 00:00:00
abstract：:The effects of a 5-day ganglioside (GM1) treatment (30 mg/kg) on body weight and water intake subsequent to medial septal lesions were evaluated for 44 consecutive days. In addition, activity, rearing, and repetitive motor acts were measured on postsurgery days 5, 10, 40, and 60. The rate of increase in the body weigh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90235-7
更新日期：1989-08-28 00:00:00
abstract：:Infusion of basic fibroblast growth factor (bFGF) prevents the loss of cholinergic neurons in the septum/diagonal band of broca following fimbria-fornix transection. However, an in vivo test of whether bFGF will also rescue injured non-cholinergic or cortical neurons has not been carried out. Previous studies have sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91707-l
更新日期：1992-09-25 00:00:00
abstract：:Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.045
更新日期：2011-08-17 00:00:00
abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90585-y
更新日期：1990-05-07 00:00:00
abstract：:Nitric oxide (NO) is a neuronal messenger that it is thought to be involved in the nociceptive transmission modulation. The activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) was shown to be identical to NOS activity in the brain. Since the periaqueductal gray matter (PAG) plays an important ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00255-8
更新日期：1998-05-18 00:00:00
abstract：:In this research, we investigated striatal neurogenesis in 3-, 6-, 12-, and 18-month-old rats after cerebral ischemic injury. All rats were subjected to a 20-min middle cerebral artery occlusion (MCAO), given 5'-bromodeoxyuridine (BrdU, 30 mg/kg, i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO. Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.043
更新日期：2007-08-29 00:00:00
abstract：:Intracellular staining of neurons located in the superficial layers of the superior colliculus (SC) of the cat was carried out through an intracellular recording micropipette with which responses to stimulation of the optic chiasm (OX) and the optic tract (OT) ipsilateral to the explored SC were recorded. :A total of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90180-3
更新日期：1981-07-27 00:00:00
abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91131-w
更新日期：1992-10-30 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90653-6
更新日期：1987-01-01 00:00:00
abstract：:A study was made of the release of excitatory, inhibitory and other amino acids from epileptic foci induced in the sensorimotor cortex of rats by cobalt implantation. A new in vivo superfusion method was employed which gives free movement to the animals and allows study over periods of days and weeks. Most amino acids...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90781-2
更新日期：1976-07-30 00:00:00
abstract：:A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91529-5
更新日期：1986-12-10 00:00:00
abstract：:Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91425-g
更新日期：1990-04-30 00:00:00
abstract：:Bilateral microinjection of kainic acid (30-117 pmol) into the substantia nigra induced convulsive seizures resembling those elicited from limbic system structures. The convulsive seizures, which consisted of facial and forelimb clonus with rearing and falling, developed after a latency of more than 30 min and were pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91661-y
更新日期：1990-10-01 00:00:00
abstract：:Local formation of oestrogens from androgens by aromatase cytochrome P-450 within brain cells is crucial for the sexual differentiation of the mammalian CNS. Aromatase activity has been detected in several brain regions of the developing rodent brain. In the present study, we used a mouse-specific, peptide-generated, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90651-3
更新日期：1994-02-28 00:00:00
abstract：:Correlative light and electron microscopic methods were used to examine the morphology, distribution and synaptic connections of double bouquet cells immunoreactive for the calcium-binding protein calbindin D-28k in the human temporal neocortex. Double bouquet cells form symmetric synapses with small dendritic shafts ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00641-3
更新日期：1995-08-28 00:00:00
abstract：:Cortical stimulation has been demonstrated to alleviate certain pain conditions. The aim of this study was to determine the responses of the spinal cord dorsal horn neurons to stimulation of the primary somatosensory cortex (SSC). We hypothesized that direct stimulation of the SSC will inhibit the activity of spinal d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.044
更新日期：2005-09-28 00:00:00
abstract：:Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90494-5
更新日期：1988-08-16 00:00:00
abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.048
更新日期：2006-08-04 00:00:00
abstract：:The present study combined masked priming with electrophysiological recordings to investigate orthographic priming effects with nonword targets. Targets were pronounceable nonwords (e.g., STRENG) or consonant strings (e.g., STRBNG), that both differed from a real word by a single letter substitution (STRONG). Targets ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.050
更新日期：2011-04-22 00:00:00
