NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats.

abstract：:The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...

journal_title：Brain research

authors： Ben-Barak J,Dudai Y

更新日期：1979-04-27 00:00:00

abstract：:The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2...

journal_title：Brain research

authors： Nilsson P,Ronne-Engström E,Flink R,Ungerstedt U,Carlson H,Hillered L

更新日期：1994-02-21 00:00:00

abstract：:The purpose of this study was to identify the functional fields activated in relation to the self-paced proximal and distal arm movements. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and 15O-labelled H2O (H2(15)O) in eight healthy subjects. All subjects performed the fo...

journal_title：Brain research

authors： Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Takahashi K,Yanagisawa T,Fukuda H

更新日期：1996-04-15 00:00:00

abstract：:This study examined the behavioral effects of agents active at the gamma-aminobutyric acid (GABA(A)) receptor complex in the mouse staircase paradigm. The neuroactivesteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were compared with the benzodiazepine agonist clonazepam, the non-benz...

journal_title：Brain research

authors： Weizman R,Paz L,Peter Y,Toren P,Pick CG

更新日期：2001-05-18 00:00:00

abstract：:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...

journal_title：Brain research

authors： Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

更新日期：1984-01-16 00:00:00

abstract：BACKGROUND:Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction. AIM:To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients...

journal_title：Brain research

authors： Hildre AS,Solvang SH,Aarsland D,Midtun Ø,McCann A,Ervik AO,Nygård O,Ueland PM,Nordrehaug JE,Giil LM

更新日期：2020-01-01 00:00:00

abstract：:Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...

journal_title：Brain research

authors： Gilbert ME,Mack CM

更新日期：1990-06-11 00:00:00

abstract：:In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (...

journal_title：Brain research

authors： Dazzi L,Matzeu A,Biggio G

更新日期：2011-04-22 00:00:00

abstract：:Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...

journal_title：Brain research

authors： Han MF,Livesey PJ

更新日期：1977-04-15 00:00:00

abstract：:Mapping studies with central drug injections in the hungry rat have identified the perifornical lateral hypothalamus as being uniquely sensitive to the feeding suppressive effects of exogenous dopamine, as well as anorexic drugs which release endogenous catecholamines. In the present study, the hypothalamic dopamine-r...

journal_title：Brain research

authors： Leibowitz SF,Rossakis C

更新日期：1979-08-17 00:00:00

abstract：:Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 microliters as measured by microdialysis, values less than half those seen in normal striatum. The increase was ...

journal_title：Brain research

authors： Keefe KA,Stricker EM,Zigmond MJ,Abercrombie ED

更新日期：1990-09-17 00:00:00

abstract：:The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...

journal_title：Brain research

authors： Rüb U,Schultz C,Del Tredici K,Braak H

更新日期：2001-07-27 00:00:00

abstract：:Methylenedioxymethamphetamine (MDMA, Ecstasy) is a powerful releaser of serotonin. Increasing recreational use of this stimulant and hallucinogenic drug has raised concerns about its potential to produce brain damage. The vast majority of previous research studies have focused on the compound's ability to deplete sero...

journal_title：Brain research

authors： Schmued LC

更新日期：2003-06-06 00:00:00

abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...

journal_title：Brain research

authors： Gómez RA,Pozzo Miller LD,Aoki A,Ramírez OA

更新日期：1990-12-24 00:00:00

abstract：:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...

journal_title：Brain research

authors： Hackett JT

更新日期：1976-09-10 00:00:00

abstract：:Previous studies in this laboratory have demonstrated that cholinergic receptors within the spinal cord play an important role in the expression of naloxone-precipitated withdrawal symptoms in the morphine-dependent rat. Related cardiovascular studies in non-dependent animals have demonstrated that this spinal choline...

journal_title：Brain research

authors： Buccafusco JJ,Terry AV Jr,Shuster L

更新日期：1995-05-15 00:00:00

abstract：:Immunohistochemical studies in rats have demonstrated dopaminergic input onto medium spiny neurons of the striatum. Medium spiny neurons, however, are known to consist of two major neuropeptide-specific types, those containing substance P (SP) and those containing enkephalin. Although both of these types have been sho...

journal_title：Brain research

authors： Karle EJ,Anderson KD,Reiner A

更新日期：1992-02-14 00:00:00

abstract：:Female B6C3F1 mice were rendered tolerant-dependent on morphine by a combination of injections and pellet implantation. Mice were injected with morphine sulfate (20 mg/kg, s.c.) twice a day on day 1. On day 2, they were implanted s.c. with a 75 mg morphine pellet for 3 days. On day 5, the pellets were either left inta...

journal_title：Brain research

authors： Bhargava HN,Thomas PT,Thorat S,House RV

更新日期：1994-04-11 00:00:00

abstract：:Unilateral microinjections (0.20 microliter) of the excitatory amino acids (EAA), L-aspartate (ASP), D,L-homocysteate (DLH) or kainate (KA) were made into the midbrain of freely moving cats. Injections of DLH (20 nmol) or ASP (200 nmol) made within the midbrain periaqueductal grey matter (PAG) consistently elicited a ...

journal_title：Brain research

authors： Bandler R,Carrive P

更新日期：1988-01-26 00:00:00

abstract：:Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicke...

journal_title：Brain research

authors： Foidart A,Tlemçani O,Harada N,Abe-Dohmae S,Balthazart J

更新日期：1995-12-01 00:00:00

abstract：:Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinu...

journal_title：Brain research

authors： Nordberg A,Wahlström G

更新日期：1982-08-19 00:00:00

abstract：:Data from several laboratories indicate that cerebral endothelial cells possess cell surface receptors for numerous vasoactive agents including angiotensin II (AII) and atrial natriuretic factor (ANF). The intracellular messengers of these receptors as well as possible receptor interactions were explored. ANF increase...

journal_title：Brain research

authors： Grammas P,Giacomelli F,Bessert D,Wiener J

更新日期：1991-10-18 00:00:00

abstract：:We investigated the effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) on cytosolic free calcium ([Ca2+]i) at a single cell level in both type-1 and type-2 cultured rat astrocytes using a calcium-sensitive fluorescent dye, fura-2. Type-1 astrocytes were relatively silent during the 20 min observat...

journal_title：Brain research

authors： Tatsuno I,Arimura A

更新日期：1994-10-31 00:00:00

abstract：:Pretreatment with scopolamine, 3 mg/kg, prevented the acquisition of a passive avoidance task in rats. These amnesic effects of scopolamine could largely be overcome by treatment with 100 mg/kg of the nootropic drug piracetam. In order to identify the brain structures involved, the effects of these drugs on regional e...

journal_title：Brain research

authors： Piercey MF,Vogelsang GD,Franklin SR,Tang AH

更新日期：1987-10-20 00:00:00

abstract：:There exists evidence to support the notion that the segmental reflex system is not fixed and inflexible, but rather is highly modifiable under a variety of circumstances. In this study the H-wave and M-wave recruitment curves were obtained from 19 subjects, utilizing the procedures outlined by Hugon. Each subject was...

journal_title：Brain research

authors： Koceja DM,Trimble MH,Earles DR

更新日期：1993-11-26 00:00:00

abstract：:Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop hypertension and stroke at earlier ages than do nonmalignant SHRSP. Our previous findings suggested that reactive oxygen species were involved in the development of stroke in this strain. Nitric oxide (NO) which is more released at ischemia, migh...

journal_title：Brain research

authors： Tabuchi M,Umegaki K,Ito T,Suzuki M,Tomita I,Ikeda M,Tomita T

更新日期：2002-09-13 00:00:00

abstract：:Nerve growth factor (NGF) transported intraaxonally from the adrenergic nerve terminals in the iris to the cell bodies in the superior cervical ganglion resulted in an increase in the activity of the enzyme ornithine decarboxylase in the ganglion. This occurred in both six-day-old and adult rats with the relative effe...

journal_title：Brain research

authors： Hendry IA,Bonyhady R

更新日期：1980-10-27 00:00:00

abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...

journal_title：Brain research

authors： Takamatsu K,Uyemura K

更新日期：1992-02-07 00:00:00

abstract：:We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...

journal_title：Brain research

authors： Gober MD,Laing JM,Thompson SM,Aurelian L

更新日期：2006-11-13 00:00:00

abstract：:The activity of incertohypothalamic, tuberoinfundibular, mesolimbic and nigrostriatal dopamine (DA) neurons was estimated by measuring the rate of turnover of DA (decline of DA after alpha-methyltyrosine) in brain regions containing the cell bodies and terminals of these neurons. Estradiol benzoate (25 micrograms/kg/d...

journal_title：Brain research

authors： Lookingland KJ,Moore KE

更新日期：1984-12-03 00:00:00