Abstract:
:Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death. Activation of N-methyl-D-aspartate (NMDA) and non-NMDA ionotropic GluRs caused cell swelling. The concentration-response relationships and the time courses of the onset of agonist-induced swelling were very similar for NMDA and kainate (KA). However, cells were able to recover from KA but not NMDA-induced swelling. Results from ion substitution experiments suggest that sodium, chloride and to a lesser extent calcium ions play critical roles in this swelling. Heterogeneity in the response to NMDA occurred within cells of the neostriatum. Approximately 15% of the cells did not swell when exposed to NMDA. The magnitude of the NMDA-induced swelling also varied depending on the region of the nervous system. Swelling was greater in the neostriatum and neocortex than in the hippocampus and it did not occur in the suprachiasmatic nucleus. In conclusion, IR DIC videomicroscopy can be used to follow quantitatively the dynamics of GluR-evoked responses in single cells and should be instrumental in determining the factors capable of modifying excitotoxicity.
journal_name
Brain Resjournal_title
Brain researchauthors
Colwell CS,Levine MSdoi
10.1016/0006-8993(96)00323-xsubject
Has Abstractpub_date
1996-06-17 00:00:00pages
205-12issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00323-Xjournal_volume
724pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Apart from the essential role of 1alpha,25-dihydroxyvitamin D3 in calcium and phosphorus metabolism, this compound and its analogs are involved in regulating the functions of the central nervous and immune systems. Active forms of vitamin D3 have been reported to stimulate neurotrophin gene expression and to prevent n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.034
更新日期:2005-03-28 00:00:00
abstract::The effects of forced swimming for 30 min on extracellular 5-hydroxytryptamine (5-HT) levels were examined in five brain regions in rats using in vivo microdialysis. A single dialysis probe was implanted under surgical anesthesia into either the striatum, ventral hippocampus, frontal cortex, amygdala, or lateral septu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00349-u
更新日期:1995-06-05 00:00:00
abstract::Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90129-9
更新日期:1982-04-29 00:00:00
abstract::Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01189-7
更新日期:1995-12-15 00:00:00
abstract::This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146387
更新日期:2019-11-15 00:00:00
abstract::Humans flexibly adapt their behavior using feedback from their environment. This ability is impaired in old age, but recent research suggests this mainly concerns processing of negative feedback and that positive feedback might be spared. The aim of this study was to test this idea of an age-related positivity bias ag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.011
更新日期:2019-08-15 00:00:00
abstract::In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90771-8
更新日期:1988-06-07 00:00:00
abstract::Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.009
更新日期:2006-12-13 00:00:00
abstract::Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)81705-2
更新日期:1997-11-07 00:00:00
abstract::Effects of systemic administration of a single dose (50 mg/kg) of ethosuximide (ESM) on extracellularly recorded thalamic (nucleus centralis lateralis, CL; nucleus reticularis, RE) and cortical neurons and on cortical EEG activity of acute cats, have been studied. In intact animals ESM led to: (a) desynchronization of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90280-1
更新日期:1989-09-18 00:00:00
abstract::The development of the endothelial system of the rat cerebellum was studied by immunohistochemical techniques with two antibodies specific of two membrane antigens characteristic of 'mature' endothelial cells. It appears that the maturation of endothelial cells is very late in the rat cerebellum. This absence of a ful...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90149-x
更新日期:1985-01-01 00:00:00
abstract::We examined the responsiveness of rat vestibular ganglion neurons (VGNs) to exogenous neurotrophic factors, BDNF, NT-3, and GDNF, during postnatal development in dissociated cultures. VGNs were obtained from postnatal days (P) 1, 3, 7, and 14. After two days in culture, the survival of VGNs in control cultures without...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.06.058
更新日期:2011-08-23 00:00:00
abstract::Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.022
更新日期:2010-09-24 00:00:00
abstract::Ischemic insults affecting the internal capsule result in sensory-motor disabilities which adversely affect the patient's life. Cerebral endothelial cells have been reported to exert a protective effect against brain damage, so the transplantation of healthy endothelial cells might have a beneficial effect on the outc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.06.042
更新日期:2012-08-21 00:00:00
abstract::How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2007.06.097
更新日期:2008-04-02 00:00:00
abstract::The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.12.021
更新日期:2017-02-15 00:00:00
abstract::Recent studies, which have shown an increase of plasma vasopressin (VP) in experimental motion sickness and the efficacy of VP antagonists for motion sickness, suggest an important role of VP in the development of vestibulo-autonomic responses. We have recently found evidence of the co-existence of vasopressinergic ne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02799-8
更新日期:2001-09-28 00:00:00
abstract::The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the thr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.004
更新日期:2013-08-28 00:00:00
abstract::Muscle spindles are induced during embryonic development by contact between sensory axons and undifferentiated myotubes. Neonatal guinea pigs deprived of nerve growth factor in utero can have only 15-20% of the normal number of dorsal root ganglion cells. This study demonstrates that such neonates have normal numbers ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90945-6
更新日期:1988-03-22 00:00:00
abstract::Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01410-j
更新日期:1995-02-20 00:00:00
abstract::Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through modulation of neurotransmission at GABA(A) receptors containing alpha1, alpha2, alpha3 or alpha5 subunits, and may have numerous experimental and clinical applications. The ability of non-sele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.020
更新日期:2008-05-07 00:00:00
abstract::Axonal regeneration over long distances is dependent upon events occurring both in the distal stump and in the neuronal cell body. Little is known concerning how events in the distal stump influence the cell body response to injury, or the axon reaction. In the present study, we examined this relationship for one comp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90558-5
更新日期:1993-10-29 00:00:00
abstract::The distribution of degeneration in the vestibular nuclei (VN) has been studied in transversely cut sections from 9 cats with stereotaxically performed lesions in the main reticular formation (RF) of the brain stem (Nauta of Fink and Heimer method). No projection was found from the mesencephalic reticular formation (R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90224-3
更新日期:1975-09-05 00:00:00
abstract::Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90678-5
更新日期:1990-10-15 00:00:00
abstract::The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91583-0
更新日期:1994-08-15 00:00:00
abstract::Inflammation and immune response have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, increased TLR4 expression has been associated with the development of cerebral vasospasm in a rabbit model of SAH. Peroxisome proliferator-activated receptor gamma (PPARgamma) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.073
更新日期:2010-03-31 00:00:00
abstract::Maternal melatonin readily crosses the placenta to provide the fetus with time-of-day and day length information. To determine if melatonin could have a broader role during development than is currently recognized, melatonin receptor expression was examined in somatic sites during Siberian hamster embryogenesis. Using...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91424-y
更新日期:1991-12-24 00:00:00
abstract::Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90771-x
更新日期:1976-07-30 00:00:00
abstract::Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2015.10.001
更新日期:2017-02-01 00:00:00
abstract::In the developing vertebrate retina, precise coordination of retinal progenitor cell proliferation and cell-cycle exit is essential for the formation of a functionally mature retina. Unregulated or disrupted cell proliferation may lead to dysplasia, retinal degeneration or retinoblastoma. Both cell-intrinsic and -extr...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2007.04.076
更新日期:2008-02-04 00:00:00