Abstract：
:Ischemic insults affecting the internal capsule result in sensory-motor disabilities which adversely affect the patient's life. Cerebral endothelial cells have been reported to exert a protective effect against brain damage, so the transplantation of healthy endothelial cells might have a beneficial effect on the outcome of ischemic brain damage. In this study, endothelin-1 (ET-1) was injected into the rat internal capsule to induce lacunar infarction. Seven days after ET-1 injection, microvascular endothelial cells (MVECs) were transplanted into the internal capsule. Meningeal cells or 0.2% bovine serum albumin-Hank's balanced salt solution were injected as controls. Two weeks later, the footprint test and histochemical analysis were performed. We found that MVEC transplantation improved the behavioral outcome based on recovery of hind-limb rotation angle (P<0.01) and induced remyelination (P<0.01) compared with the control groups. Also the inflammatory response was repressed by MVEC transplantation, judging from fewer ED-1-positive activated microglial cells in the MVEC-transplanted group than in the other groups. Elucidation of the mechanisms by which MVECs ameliorate ischemic damage of the white matter may provide important information for the development of effective therapies for white matter ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Puentes S,Kurachi M,Shibasaki K,Naruse M,Yoshimoto Y,Mikuni M,Imai H,Ishizaki Ydoi
10.1016/j.brainres.2012.06.042subject
Has Abstractpub_date
2012-08-21 00:00:00pages
43-53eissn
0006-8993issn
1872-6240pii
S0006-8993(12)01117-1journal_volume
1469pub_type
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