Abstract：
:Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxia and expression of the primary signaling factors involved in the process. Four-month old male C57BL/6 mice were housed and maintained in a hypobaric chamber at 290 Torr (0.4 atm) for 21 days and allowed to recover at normoxia (room air) for up to 21 days. The mice were either decapitated or perfused in-situ and brain samples collected were either homogenized for Western blot analysis or fixed and embedded in paraffin for immunohistochemistry. Hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and erythropoietin (EPO) expression were increased during hypoxic exposure and diminished during subsequent re-oxygenation. However, cyclooxygenase-2 (COX-2) and angiopoietin-2 (Ang-2) were both elevated during hypoxia as well as subsequent re-oxygenation. Significantly increased capillary density at the end of the 3rd week of hypoxia regressed back toward normoxic baseline as the duration of re-oxygenation continued. In conclusion, elevated COX-2 and Ang-2 expression during hypoxia where angiogenesis occurs and re-oxygenation, when micro-vessels regress, identifies these proteins as vascular remodeling molecules crucial for angioplasticity.
journal_name
Brain Resjournal_title
Brain researchauthors
Benderro GF,LaManna JCdoi
10.1016/j.brainres.2014.04.035subject
Has Abstractpub_date
2014-06-20 00:00:00pages
41-7eissn
0006-8993issn
1872-6240pii
S0006-8993(14)00583-6journal_volume
1569pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.022
更新日期：2014-11-07 00:00:00
abstract：:Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cort...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1991-04-26 00:00:00
abstract：:Generalized barrel-rolling convulsions and focal hypermetabolic responses in the cerebellar cortex of conscious rats to lateral ventricular injection of the neuropeptide, endothelin-1 (ET; 9 pmol), were diminished or eliminated by i.c.v. pretreatment with the glutamatergic NMDA receptor antagonist, MK-801 (44 nmol). U...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91334-x
更新日期：1994-06-06 00:00:00
abstract：:Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra became briefly sedated and hypothermic after the acute injection of nicotine s.c. (0.4 or 0.8 mg/kg free base). When nicotine was repeated 5 days per week there was rapid tolerance for the sedation and slower tolerance for the hypothermia and the l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91114-0
更新日期：1987-03-31 00:00:00
abstract：:Anandamide (arachydonylethanolamide) is a naturally-occurring ligand of the canabinoid receptor. When anandamide binds to its receptor, adenylate cyclase is inhibited. At the frog neuromuscular junction, anandamide lessened the increase in quantal size produced by pretreatment in hypertonic solution. It did not alter ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91062-6
更新日期：1994-06-27 00:00:00
abstract：:Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.086
更新日期：2010-08-06 00:00:00
abstract：:The dorsolateral funiculus (DLF) spinal pathway has previously been identified as a major pathway involved in descending modulation of pain. While bilateral lesions of the DLF attenuated systemic morphine analgesia as measured by the tail-flick test, they failed to attenuate analgesia as measured by the formalin test....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90582-7
更新日期：1985-05-13 00:00:00
abstract：:Microarray analysis has been used to understand how gene regulation plays a critical role in neuronal injury, survival and repair following ischemic stroke. To identify the transcriptional regulatory elements responsible for ischemia-induced gene expression, we examined gene expression profiles of rat brains following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.052
更新日期：2013-02-07 00:00:00
abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01590-5
更新日期：1999-07-24 00:00:00
abstract：:Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as amphetamine and cocaine have been reported. However, genetic differences in the locomotor responses of rat strains to methylphenidate (MPD), a commonly used psychostimulant in the treatment of attention deficit/hyperac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04240-3
更新日期：2003-05-09 00:00:00
abstract：:Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90701-7
更新日期：1979-12-14 00:00:00
abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00779-8
更新日期：1997-10-10 00:00:00
abstract：:Insulin-like growth factor (IGF) II receptors were studied in human adult brain by using autoradiography with [125I]IGF-II. Receptors were found to be widely distributed throughout all neuronal regions. The highest densities were found in plexus choroideus, granular layer of the cerebellar cortex, gyrus dendatus and p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02153-3
更新日期：2000-04-28 00:00:00
abstract：:We are interested in studying the co-localization of NMDA glutamate receptor subunits (NR1, NR2A/B) and AMPA glutamate receptor subunits (GluR1, GluR2, GluR2/3 and GluR4) in individual neurons of the rat vestibular nuclei. Immunoreactivity for NR1, NR2A/B, GluR1, GluR2, GluR2/3 and GluR4 was found in the somata and de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02913-9
更新日期：2000-11-24 00:00:00
abstract：:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01953-8
更新日期：1999-12-18 00:00:00
abstract：:In this study, the effects of chronic morphine administration (20-30 days) on long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices. Orthodromic population spike (OPS) amplitude and delay (peak latency) were measured as indices of increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01148-2
更新日期：1999-01-09 00:00:00
abstract：:Neurogenesis might influence oligodendrogenesis and selectively instruct myelination in the mammalian brain. Running exercise could induce neurogenesis and protect the myelin sheaths in the dentate gyrus of AD mice. It is unclear whether running exercise can protect myelin sheaths in the absence of neurogenesis in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.007
更新日期：2018-04-01 00:00:00
abstract：:Activation of cAMP-dependent protein kinase (kinase A) has recently been shown to enhance responses evoked by stimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in cultured hippocampal pyramidal neurons. Here we report results of experiments designed to determine if activation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90803-h
更新日期：1992-03-06 00:00:00
abstract：:The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90731-n
更新日期：1992-05-29 00:00:00
abstract：:Previous studies have demonstrated that some anticonvulsant drugs can modulate tolerance to the opioid analgesia. In the present study, the effects of lamotrigine (LTG) on the development and expression of tolerance to the morphine-induced antinociception were evaluated using tail-flick test. To assess the LTG effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.014
更新日期：2009-09-29 00:00:00
abstract：:Porcine calcitonin (pCT) encapsulated in sulfatide-containing reverse-phase evaporation vesicles (REVs) was shown to induce long-lasting and dose-dependent antinociceptive effect by systemic injection in mice. Its antinociceptive activity is found to be dependent on the route of administration. In contrast, neither un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91311-f
更新日期：1993-02-12 00:00:00
abstract：:The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90323-8
更新日期：1984-06-25 00:00:00
abstract：:Recent evidence suggests that cocaine addiction may involve progressive drug-induced neuroplasticity of the dorsal striatum. Here, we examined the effects of a) dorsolateral caudate putamen (dlCPu) lesions on cocaine self-administration, extinction of responding, and subsequent reinstatement to cocaine-seeking, and b)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.030
更新日期：2011-10-12 00:00:00
abstract：:The ability of beta-phenylethylamine (PEA) to reverse (1) chlorpromazine-induced activation of striatal tyrosine hydroxylase, and (2) catalepsy produced by chlorpromazine, was examined. PEA, in a dose of 75 mg/kg, caused approximately 50% reduction in the degree of tyrosine hydroxylase stimulation produced by 20 mg/kg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90979-3
更新日期：1981-05-04 00:00:00
abstract：:The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90395-2
更新日期：1988-11-01 00:00:00
abstract：:The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91237-u
更新日期：1991-09-27 00:00:00
abstract：:The CNP neuropeptides (Command Neuron Peptides) were first found in the command neurons for withdrawal behavior in the terrestrial snail. Given the fact that certain peptides can be found in various invertebrates, we examined Drosophila brains to determine if CNP-like peptides were present. Two types of antisera were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.038
更新日期：2007-06-04 00:00:00
abstract：:Alzheimer's disease (AD) classically presents with gray matter atrophy, as well as feature significant white matter abnormalities. Previous evidence indicates the overall burden of these pathological changes continues to advance as the disease progresses. The aim of this study was to investigate whether pathological a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.052
更新日期：2013-06-17 00:00:00
abstract：:Past studies of polymer-encapsulated cell lines implanted in the brain indicated their usefulness for transmitter replacement therapy in animal models. Such grafts may have potentially important clinical applications, but their placement into neural parenchyma may cause a traumatic injury resulting in a leaky blood-br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90929-p
更新日期：1991-06-14 00:00:00
abstract：:Myelin-associated glycoprotein (MAG) is susceptible to proteolysis by a calcium-activated neutral protease which is located in myelin. The conversion of MAG (M(r) 100,000) to its soluble derivative dMAG (M(r) 90,000) occurs much more rapidly in myelin from human white matter than in myelin from rat brain, and the rate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00882-7
更新日期：1996-11-25 00:00:00
