Abstract:
:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of psychostimulants. In the present study, we examined the effects of acute and repeated amphetamine administration on the expression and production of this factor in the forebrain of rats. Animals given a single, acute injection (5 mg/kg, i.p.) of D-amphetamine developed hyperactivity followed by stereotypical behavior but showed no change in the basal expression of BDNF mRNA or its immunocytochemical profile in any region except the piriform cortex. Repeated injections (5 days) of 5 mg/kg amphetamine were accompanied by an enhanced onset of stereotypical behavior and elevated BDNF mRNA in the basolateral amygdala, rostral piriform cortex and paraventricular nucleus of the hypothalamus. Repeated treatment also increased BDNF immunoreactivity in perikarya of these same regions. In addition, increased BDNF immunoreactivity was found in fibers of many projection targets of the basolateral amygdala--the central extended amygdala, olfactory tubercle, medial nucleus accumbens, and in small zones resembling striosomes in the dorsal medial striatum. These results suggest that the upregulation of BDNF expression and protein in the basolateral nucleus of the amygdala and its targets could be an important part of the neuroadaptive response to psychostimulants.
journal_name
Brain Resjournal_title
Brain researchauthors
Meredith GE,Callen S,Scheuer DAdoi
10.1016/s0006-8993(02)03160-8subject
Has Abstractpub_date
2002-09-13 00:00:00pages
218-27issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302031608journal_volume
949pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Cerebral blood flow (CBF) and blood flow (BF) in extracerebral head structures were measured during the sleep-wake cycle in rats using radioactive microspheres. While no statistically significant changes occurred in the transition from Waking to quiet sleep (also referred to as synchronized or non-REM Sleep), CBF incr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91813-9
更新日期:1994-03-28 00:00:00
abstract::Inflammation and immune response have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, increased TLR4 expression has been associated with the development of cerebral vasospasm in a rabbit model of SAH. Peroxisome proliferator-activated receptor gamma (PPARgamma) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.073
更新日期:2010-03-31 00:00:00
abstract::Somatostatin-like immunoreactivity (Som-LI) and glycine high-affinity uptake have been characterized in the Rana pipiens retina. These labels are found in both the outer and inner plexiform layers (OPL and IPL), suggesting that interplexiform cells (IPCs) contain both Som and glycine in this retina. In double-label ex...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91215-8
更新日期:1989-08-21 00:00:00
abstract::There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02965-7
更新日期:2002-09-13 00:00:00
abstract::The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.074
更新日期:2010-01-22 00:00:00
abstract::A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91641-6
更新日期:1987-12-29 00:00:00
abstract::In the neonatal kitten, cuneate neurones activated by tactile stimulation of the forelimb foot pads are divisible into 3 functional classes each of which appears to receive its glabrous skin input selectively from a single class of tactile receptors. Their properties suggest that the functionally specific patterns of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90081-x
更新日期:1981-06-01 00:00:00
abstract::The synaptic regulatory mechanism of resting membrane potential of layer III and V pyramidal neurons was analyzed intracellularly in the slice preparation of cat sensorimotor cortex. During the tetanic stimulation of white matter, subthreshold membrane depolarization was induced, and after that, a slowly developing hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02353-2
更新日期:2000-06-30 00:00:00
abstract::The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90585-y
更新日期:1990-05-07 00:00:00
abstract::It was previously proposed that norepinephrine (NE)-containing nerve terminals in visual cortex are important for the maintenance of cortical plasticity. Observations at that time indicated that local microperfusion of exogenous NE for 1 week directly into kitten visual cortex, with no alteration of the visual environ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91288-5
更新日期:1984-06-04 00:00:00
abstract::Effects of pre-treatment of synaptic membranes with beta-adrenoceptor agonists and cholera toxin on [3H]clonidine and [3H]yohimbine binding were examined in rat cerebral cortex. Pre-incubation of cerebral cortical membranes with isoproterenol (10 or 200 microM) or dobutamine (1, 10 or 200 microM) at 37 degrees C for 4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90531-1
更新日期:1985-03-11 00:00:00
abstract::Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS)--selected ion monitoring technique using deuterated internal standards in rats allowed to self-inject either acetaldehyde, ethanol or saline control solution over 20 days for 1 h/day. Significant increases in m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90955-2
更新日期:1985-12-09 00:00:00
abstract::Cerebrospinal fluid (c.s.f.) pressure and resistance to absorption have been studied in exteriorized fetuses (18 to 21 days gestation) from pregnant rats anaesthetised with pentobarbitone and in similarly anaesthetised postnatal rats at 1, 5, 10 and 30 days after birth and in adults. The resting c.s.f. pressure was lo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90172-6
更新日期:1987-05-01 00:00:00
abstract:UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90357-5
更新日期:1988-07-19 00:00:00
abstract::The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00151-0
更新日期:1997-04-11 00:00:00
abstract::The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.01.033
更新日期:2017-04-01 00:00:00
abstract::Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90308-1
更新日期:1984-12-10 00:00:00
abstract::Brain microdialysis and high-performance liquid chromatography with electrochemical detection were utilized to study the effect of the selective non-competitive NMDA antagonist MK-801 (dizocilpine) on striatal dopamine (DA) release in the anesthetized rat. Perfusion of 100 microM and 300 microM (+/-)-MK-801 through th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91828-7
更新日期:1994-03-28 00:00:00
abstract::The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91089-y
更新日期:1990-04-09 00:00:00
abstract::This study examined whether cardiac beta-adrenoceptor (beta-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) beta(1,2)-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) beta(3)- and/or atypical beta-AR-mediated tach...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02744-5
更新日期:2001-09-14 00:00:00
abstract::We examined the effects of chronic social stress and social rank on monamine concentrations in the prefrontal cortex (PFC) in adult male cynomolgus macaques (Macaca fascicularis). Seventy-five animals were housed in five-member social groups for 28 months and were exposed to three experimental conditions. A 'no-stress...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01146-3
更新日期:1995-12-24 00:00:00
abstract::Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. The present study was designed to investigate the beneficial effects of mdivi-1 against sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.03.033
更新日期:2015-09-04 00:00:00
abstract::The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be rema...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91021-j
更新日期:1993-06-18 00:00:00
abstract::The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.03.010
更新日期:2015-06-22 00:00:00
abstract::Damage to the cerebral endothelium from ischemia could exacerbate brain injury by altering vascular integrity, but little is known concerning the response of cerebral endothelial cells to hypoxia. To address this issue, cerebral capillary endothelial cells were isolated from 14-day-old rats, grown to confluence, and p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90367-0
更新日期:1994-08-08 00:00:00
abstract::Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90818-0
更新日期:1981-10-26 00:00:00
abstract::Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90087-9
更新日期:1988-01-01 00:00:00
abstract::Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91295-x
更新日期:1989-05-01 00:00:00
abstract::The success of neuromodulation therapies, particularly in the brain, spinal cord, and peripheral nerves, has been greatly aided by computational, biophysical models. However, treating gastrointestinal disorders with electrical stimulation has been much less explored, partly because the mode of action of such treatment...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.02.038
更新日期:2018-08-15 00:00:00
abstract::Rats reared on a diet in which choline is replaced with N-aminodeanol (NADE), undergo > 50% replacement of brain acetylcholine with acetylated NADE, a false cholinergic transmitter. We examined amounts of sleep and wakefulness in 7 littermate pairs of rats fed either NADE-substituted, or a choline control diet for > 1...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90492-6
更新日期:1993-11-26 00:00:00