Abstract：
:The levels of PLCgamma, a phospholipase C (PLC) isozyme, were higher in the cytosol fraction than in the membrane fraction in several control brain regions. The levels of PLCgamma were significantly elevated in the membrane, but not in the cytosolic fraction of the hippocampus of AD subjects. In the superior and middle temporal gyri (SMTG) of AD subjects, the levels of PLCgamma were significantly elevated in both the membrane and cytosolic fractions. In the inferior parietal lobule and cerebellum of AD subjects, no significant changes were found in the PLCgamma levels of either cytosolic or membrane fractions. These results suggest that the increased levels of PLCgamma, by increasing the hydrolysis of PIP2 in the hippocampus and SMTG, may contribute to pathophysiology of AD. These results also support a role for excitatory neurotransmitters and their receptors in AD.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang D,Dhillon H,Prasad MR,Markesbery WRdoi
10.1016/s0006-8993(98)00935-4subject
Has Abstractpub_date
1998-11-16 00:00:00pages
161-5issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00935-4journal_volume
811pub_type
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