Abstract：
:The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following the induction of tonic pain produced hyperalgesia during the tonic phase only. These findings suggest that endogenous cannabinoids serve naturally to modulate the maintenance of pain following repeated noxious stimulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Strangman NM,Patrick SL,Hohmann AG,Tsou K,Walker JMdoi
10.1016/s0006-8993(98)01031-2subject
Has Abstractpub_date
1998-12-07 00:00:00pages
323-8issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01031-2journal_volume
813pub_type
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