Abstract：
:The melanocortin (MC)4 receptor is important for food intake and weight homeostasis as it mediates the orexigenic and anorexigenic effects of the MCs. OLETF (Otsuka-Long-Evans-Tokushima-Fatty) rats are a selective inbred strain of polygenic variant rats which overeat and develop obesity with elevated leptin levels. We investigated by autoradiography if the expression of MC receptors were altered in ovariectomized estradiol-replaced female OLETF rats compared to their controls (Long-Evans-Tokushima-Otsuka (LETO) rats). We found that OLETF rats show a reduction in total [125I]NDP-MSH MC receptor binding in the ventromedial hypothalamic nucleus, perhaps reflecting an increased release of MC peptides in this region. The levels of MC receptors in the arcuate nucleus and the paraventricular hypothalamic nucleus were not changed. Interestingly, the OLETF rats also showed reduced MC-receptor binding in areas such as the nucleus accumbens shell, and the ventral tegmental area, both of which are believed to be involved in reward systems. Similarities in the changes of MC receptor expression in obese animals and in animals treated with opiates may suggest a neurobiological link between food intake mediated through the MC receptors and reward.
journal_name
Brain Resjournal_title
Brain researchauthors
Lindblom J,Schiöth HB,Watanobe H,Suda T,Wikberg JE,Bergström Ldoi
10.1016/s0006-8993(99)02125-3subject
Has Abstractpub_date
2000-01-03 00:00:00pages
180-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02125-3journal_volume
852pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Temperature dysregulation is well known in generalized convulsive status epilepticus but so far has not been reported in non-convulsive forms. In order to detect possible subtle alterations, we have analyzed the capability to compensate for external cooling in an animal model of limbic status epilepticus. Rats with el...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.034
更新日期：2007-01-05 00:00:00
abstract：:The present study was designed to investigate the distribution of serotonin 5-HT1A receptor protein (5-HT1A-immunoreactivity) and its localization within cortical pyramidal neurons of the rat cingulate cortex. This experimental direction was inspired by recent data showing the role of 5-HT1A receptors in the pathology...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03352-3
更新日期：2003-10-31 00:00:00
abstract：:The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of ea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90974-r
更新日期：1993-11-19 00:00:00
abstract：:The succinic semialdehyde dehydrogenase (SSADH) null mouse (SSADH(-/-)) represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. In physiological concentrations, GH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.131
更新日期：2006-05-23 00:00:00
abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02657-3
更新日期：2000-09-08 00:00:00
abstract：:The effect of hypoxia on the structure and function of the synaptosomal membranes and myelin fraction (glial cells, neuronal cells bodies and axonal membranes) was investigated by measuring Na+,K(+)-ATPase activity and levels of lipid peroxidation products in cerebral cortical synaptosomal membranes and myelin fractio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91388-9
更新日期：1993-01-15 00:00:00
abstract：:The blood-brain interface in elasmobranchs was examined using physiological and anatomical techniques. Electrolyte analyses of plasma and cerebrospinal fluid (CSF) in control fish and in fish with elevated plasma cation concentration (Ca, Mg or K) demonstrated homeostasis of CSF calcium and magnesium concentrations in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91083-0
更新日期：1981-12-07 00:00:00
abstract：:Environmental risk factors such as stressful experiences have long been recognized to affect seizure susceptibility, but little attention has been paid to the potential effects of improving housing conditions. In this study, we investigated the influence of an enriched environment on epileptogenesis. Epileptic suscept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03355-3
更新日期：2002-11-08 00:00:00
abstract：:Rats anticipate a scheduled daily meal by entrainment of a circadian pacemaker separate from the light-entrainable circadian pacemaker located in the suprachiasmatic nuclei (SCN). The site and molecular mechanisms of the food-entrainable pacemaker are unknown. The intrinsic period (tau) of the SCN pacemaker is signifi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03042-6
更新日期：2001-11-23 00:00:00
abstract：:Concentrations of the neurotransmitters, serotonin (5-HT), dopamine (DA), and norepinephrine (NE) were measured in the developing rat brain at 12, 19, 26 and 42 days of age. The amino acid precursors, tryptophan (TRP) and tyrosine (TYR) were measured along with the 5-HT and DA metabolites, 5-hydroxyindoleacetic acid (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90146-4
更新日期：1985-01-01 00:00:00
abstract：:The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.081
更新日期：2007-04-27 00:00:00
abstract：:In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02890-0
更新日期：2000-11-10 00:00:00
abstract：:Cortical sensory neurons synchronize their activity at multiple frequency bands after an external stimulation. In the somatosensory cortical areas, previous reports describe more discrete and somatotopically specific neural synchronization at the gamma band. Therefore, an efficient gamma synchronization of the neurons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03171-8
更新日期：2003-10-03 00:00:00
abstract：:Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. In this study, monoclonal antibodies that recognize rat or monkey MAO A were used in immunocytochemical studies ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91664-e
更新日期：1993-05-28 00:00:00
abstract：:The effects of retinoic acid (RA), a naturally occurring metabolite of vitamin A, on the growth, morphology and neurochemical differentiation of the PC12 clone of rat pheochromocytoma cells were investigated. RA added to the medium inhibited the growth of PC12 cells in a dose-dependent manner up to 10 microM without a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90460-5
更新日期：1989-11-13 00:00:00
abstract：:The possible involvement of catecholamines in the regulation of serotonin N-acetyltransferase (NAT) activity in retina of the African clawed frog was investigated using an in vitro eye cup preparation. Dopamine (10 microM) and norepinephrine (50 microM) had no significant effect on NAT activity of eye cups incubated i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90525-1
更新日期：1986-03-26 00:00:00
abstract：:These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by meas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01211-5
更新日期：1997-01-02 00:00:00
abstract：:Previous studies have suggested that cardiovascular responses elicited by injection of glycine into the nucleus tractus solitarii (NTS) depend upon interactions between glycinergic and cholinergic neuronal elements in NTS. Release of acetylcholine in response to glycine is one such interaction that has been shown in s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91789-2
更新日期：1994-07-11 00:00:00
abstract：:Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.012
更新日期：2015-04-24 00:00:00
abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90728-x
更新日期：1978-06-16 00:00:00
abstract：:The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03086-5
更新日期：2003-09-05 00:00:00
abstract：:Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by another glutamate receptors, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.037
更新日期：2007-07-23 00:00:00
abstract：:The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03300-0
更新日期：2002-11-01 00:00:00
abstract：:The effect of electrolytic lesion of the paraventricular nucleus of the hypothalamus (PVN) on yawning and penile erection induced by apomorphine, oxytocin and adrenocorticotropic hormone (ACTH1-24) was studied in male rats. In sham-operated rats, apomorphine (50 micrograms/kg s.c.), oxytocin (30 ng i.c.v.), and ACTH1-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91305-9
更新日期：1987-09-22 00:00:00
abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90782-8
更新日期：1989-10-16 00:00:00
abstract：:Our purpose was to investigate the cortical information processing of autobiographical fact violation (AFV) in self-referential questions. We expected that AFV in a self-referential question would evoke a characteristic pattern of neural synchrony and event-related potentials (ERPs). Averaged ERP and event-related syn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.02.013
更新日期：2017-05-01 00:00:00
abstract：:This study investigated the effects of N6-cyclopentyladenosine (CPA), a potent and selective adenosine A1 receptor (A1R) agonist in normal and nerve-injured rats and mechanisms of its action by behavioral tests and electrophysiological technique. The results showed: (1) In normal rats, intraperitoneal administration o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.034
更新日期：2010-11-18 00:00:00
abstract：:It has been demonstrated previously that kappa opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether kappa agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02154-0
更新日期：2001-04-13 00:00:00
abstract：:This report deals with a comparison of total and regional cerebral blood flow with red cell velocity in the microcirculation of the ecto- and suprasylvian areas of the cerebral cortex of the cat and their response to changes in systemic blood pressure. Total and regional blood flows were measured during a steady-state...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90912-0
更新日期：1984-08-06 00:00:00
abstract：:Subtypes of muscarinic receptors were characterized in the frontal cortices of control and Alzheimer brains, with labelled quinuclidinyl benzilate [3H]QNB and the unlabelled muscarinic antagonists pirenzepine, AF-DX 116, hexahydro-sila-diphenidol (HHSiD), para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and himbacine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91541-l
更新日期：1992-11-20 00:00:00
