Abstract：
:Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription in the adult hypothalamus is subjected to negative regulation by thyroid hormones. However, the role of T3 on the development of TRH expression is unknown. In this study we used primary cultures derived from 17-day-old fetal rat hypothalamus to analyze the effects of T3 on TRH gene expression during development. T3 increased TRH mRNA expression in immature cultures, but decreased it in mature cultures. In addition, T3 up-regulated TRalpha1 and TRbeta2 mRNA expression. TRalpha1 expression coincided chronologically with that of TRH in the rat hypothalamus in vivo. Maturation of TRH expression in the hypothalamus may involve T3 acting through TRalpha1.
journal_name
Brain Resjournal_title
Brain researchauthors
Carreón-Rodríguez A,Charli JL,Pérez-Martínez Ldoi
10.1016/j.brainres.2009.09.042subject
Has Abstractpub_date
2009-12-11 00:00:00pages
20-30eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01945-3journal_volume
1305pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In normal adult rats, intense immunostaining for the 75 kDa low-affinity receptor for nerve growth factor and other neurotrophins (p75NGFR) is concentrated in the middle region of the cuneate nucleus (CN), distributed in a blotchy pattern similar to that of cytochrome oxidase (CO) activity. In the adult rats, partial ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90051-5
更新日期：1994-05-16 00:00:00
abstract：:We electrically stimulated individual Mauthner (M-) cells to determine their motor contribution to C-starts of swimming goldfish. In comparison with sensory-evoked C-starts, M-reflexes triggered by electrical stimulation of single M-cells were significantly weaker and less variable. Stage 1 turns were both longer in d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91012-6
更新日期：1990-05-28 00:00:00
abstract：:Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90290-9
更新日期：1988-08-30 00:00:00
abstract：:ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-directional diffusion of biologically active purines such as adenosine. In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator with complex pro- and anti-nociceptive actions. Although uptake and relea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.08.017
更新日期：2005-10-19 00:00:00
abstract：:The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly understood. In this far-reaching review, we examine what is currently known about ALS genetics and how these genes were initially identified. We also discuss the various types of mutations that might underlie this fatal neurodegenera...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.10.009
更新日期：2015-05-14 00:00:00
abstract：:Peripheral afferent innervation appears to be required for the expression of the dopamine phenotype in the rodent main olfactory bulb. Experiments utilizing neonatal naris closure as a means of sensory deprivation also suggest that odor-induced afferent activity is required for the expression of the phenotype. These e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91023-l
更新日期：1993-06-18 00:00:00
abstract：:Exposure of hippocampal slices to Mg2+ free media (0 Mg) has been shown to trigger full production of stimulus-induced seizure activity after restoration of physiological conditions [1]. In the present study employing hippocampal entorhinal cortical slices (HEC), spontaneous epileptiform discharges (SEDs) were induced...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00060-1
更新日期：1996-05-20 00:00:00
abstract：:The present experiments were designed to evaluate pharmacologically the role of three neuroanatomically related systems--dopamine, glutamate and GABA--in the motor-stimulant response to amphetamine and cocaine. The data indicate that stimulant-induced stereotypy is blocked by antagonists of all three systems and that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01334-e
更新日期：1995-02-06 00:00:00
abstract：:Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90096-2
更新日期：1983-01-01 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91704-5
更新日期：1991-12-06 00:00:00
abstract：:Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90051-7
更新日期：1982-04-01 00:00:00
abstract：:Binding sites for iodinated endothelin (ET)-2, ET-3 and vasoactive intestinal contractor (VIC) were visualised in the adult rat brain using quantitative autoradiography and have a similar anatomical distribution to that of ET-1 and sarafotoxin S6b. Highest densities of binding sites for all 5 labelled peptides were pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90201-6
更新日期：1991-07-19 00:00:00
abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01485-0
更新日期：1997-04-04 00:00:00
abstract：:During cerebral ischemia, dysregulated glutamate release activates N-methyl-d-aspartate (NMDA) receptors which promotes excitotoxicity and intracellular acidosis. Ischemia also induces cellular adenosine (ADO) release, which activates ADO receptors and reduces neuronal injury. The aim of this research was to determine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.115
更新日期：2006-04-12 00:00:00
abstract：:Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.086
更新日期：2010-08-06 00:00:00
abstract：:A commissural-associational entorhino-entorhinal projection in the guinea pig was analyzed using anterograde and retrograde axonal tracing techniques. The projection originated in layer II and terminated in layer Ia of both the medial entorhinal area (MEA) and the lateral entorhinal area (LEA). A few cells in other la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90117-0
更新日期：1989-12-25 00:00:00
abstract：:Xenopus laevis tadpoles functionally recover from spinal cord transection. Because this recovery requires the tadpole to metamorphose, it may result from compensatory changes initiated by de novo growth of axons involved in limb dominant locomotion rather than from regeneration of cut axons. To determine whether axona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.126
更新日期：2006-05-09 00:00:00
abstract：:Sleep-related changes-including modification in sensory processing-that influence brain and body functions, occur during both slow wave and paradoxical sleep. Our aim was to investigate how cortical auditory neurons behave during the sleep/waking cycle, and to study cell firing patterns in relation to the processing o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01194-9
更新日期：1999-01-23 00:00:00
abstract：:We have previously demonstrated that NMDA receptor-mediated extracellular adenosine accumulation in neuronal cultures is receptor-mediated and requires calcium influx. Because protein kinase C (PKC) is a calcium-dependent enzyme, we hypothesized that activation of PKC might be involved in NMDA-mediated adenosine accum...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.057
更新日期：2007-06-25 00:00:00
abstract：:The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90468-3
更新日期：1986-01-08 00:00:00
abstract：:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02331-3
更新日期：2000-07-28 00:00:00
abstract：:Quantitative [125I]protein G-based immunohistochemistry was used to map the distribution of beta1 thyroid hormone receptor (TRbeta1) in normal and thyroidectomized adult rat brain, using a previously characterized polyclonal antibody. The distribution of TRbeta1-like immunoreactivity in normal brain was largely but no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00450-2
更新日期：1997-06-27 00:00:00
abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.027
更新日期：2017-01-01 00:00:00
abstract：:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03129-2
更新日期：2001-01-19 00:00:00
abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.036
更新日期：2010-03-12 00:00:00
abstract：:As life spans increased, neurodegenerative disorders that affect aging populations have also increased. Progressive neuronal loss in specific brain regions is the most common cause of neurodegenerative disease; however, key determinants mediating neuron loss are not fully understood. Using a model of mitochondrial mem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.02.005
更新日期：2013-04-10 00:00:00
abstract：:Facilitation of cerebellorubral transmission was illustrated in nembutalized cats on paired stimulation of the cerebellar nucleus interpositus by an example of monosynaptic EPSPs of the rubrospinal neurons. It was found that the facilitation stated is not determined by the change in the presynaptic volley of impulses....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90334-9
更新日期：1987-05-05 00:00:00
abstract：:Dipiperidinoethane (DPE) administration produces seizures and CNS lesions. Here we elucidate the cholinergic origin of DPE toxicity. DPE is both an acetylcholinesterase (AChE) inhibitor and a muscarinic antagonist. This dual action negates most of the toxic effects of the compound in vivo. The neurotoxicity is believe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90728-0
更新日期：1985-04-01 00:00:00
abstract：:Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00595-1
更新日期：1996-10-07 00:00:00
