Neurotoxicity of dipiperidinoethane due to in vivo conversion to a selective cholinesterase inhibitor.

abstract：:MicroRNAs (miRNAs) are abundantly expressed in the brain and play an important role in disorders of the brain, including Alzheimer's diseases (AD). Growing body of evidence suggests that the TGF-β signaling pathway plays a key role in the pathogenesis of AD. However, it is unclear whether miRNAs involved in AD pathoge...

journal_title：Brain research

authors： Wang H,Liu J,Zong Y,Xu Y,Deng W,Zhu H,Liu Y,Ma C,Huang L,Zhang L,Qin C

更新日期：2010-10-21 00:00:00

abstract：:In recent decades, an increasing number of neuroimaging studies utilizing magnetic resonance imaging (MRI) have explored the differential effects of postherpetic neuralgia (PHN) on brain structure and function. We systematically reviewed and integrated the findings from relevant neuroimaging studies in PHN patients. A...

journal_title：Brain research

authors： Tang Y,Wang M,Zheng T,Xiao Y,Wang S,Han F,Chen G

更新日期：2021-02-01 00:00:00

abstract：:S-allyl cysteine (SAC), a sulfur containing amino acid derived from garlic, has been reported to have antioxidant, anti-cancer, antihepatotoxic and neurotrophic activity. This study was designed to examine the pre-treatment effects of SAC on cognitive deficits and oxidative damage in the hippocampus of intracerebroven...

journal_title：Brain research

authors： Javed H,Khan MM,Khan A,Vaibhav K,Ahmad A,Khuwaja G,Ahmed ME,Raza SS,Ashafaq M,Tabassum R,Siddiqui MS,El-Agnaf OM,Safhi MM,Islam F

更新日期：2011-05-10 00:00:00

abstract：:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...

journal_title：Brain research

authors： Beczkowska IW,Bodnar RJ

更新日期：1991-05-03 00:00:00

abstract：:Using a perifusion culture technique, the pattern of vasopressin release from the suprachiasmatic nucleus was studied in vitro under basal and stimulated conditions. Individual rat suprachiasmatic explants released vasopressin in a rhythmic fashion and these rhythms persisted with a circadian period for up to 4 cycles...

journal_title：Brain research

authors： Earnest DJ,Sladek CD

更新日期：1987-10-06 00:00:00

abstract：:Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

journal_title：Brain research

authors： Schenk JO,Miller E,Rice ME,Adams RN

更新日期：1983-10-24 00:00:00

abstract：:The peroxidase-antiperoxidase (PAP) immunohistochemical technique was used to identify neurons in the basolateral amygdaloid nucleus (BL) that contain vasoactive intestinal polypeptide (VIP), somatostatin (SOM) or cholecystokinin (CCK). Examination of immunostained neurons demonstrated that most, if not all, of these ...

journal_title：Brain research

authors： McDonald AJ

更新日期：1985-07-08 00:00:00

abstract：:Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...

journal_title：Brain research

authors： Carreón-Rodríguez A,Charli JL,Pérez-Martínez L

更新日期：2009-12-11 00:00:00

abstract：:In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...

journal_title：Brain research

authors： Angelidis A,Račeková E,Arnoul P,Závodská M,Raček A,Martončíková M

更新日期：2018-11-01 00:00:00

abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...

journal_title：Brain research

authors： Holland KD,Canney DJ,Rothman SM,Ferrendelli JA,Covey DF

更新日期：1990-05-14 00:00:00

abstract：:Previous studies have indicated that central sensitization is a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation and astrocytes play an important role in the central sensitization. The current study investigated the role of amino ac...

journal_title：Brain research

authors： Wang J,Geng B,Shen HL,Xu X,Wang H,Wang CF,Ma JL,Wang ZP

更新日期：2012-04-17 00:00:00

abstract：:The organization of corticotectal projections from the medial agranular cortex (AGm), which has been considered to contain rat's frontal eye field, was examined using anterograde and retrograde tracing techniques. When biotinylated dextranamine (BDA) injections were made into the rostral part of the AGm, small numbers...

journal_title：Brain research

authors： Tsumori T,Yokota S,Ono K,Yasui Y

更新日期：2001-06-08 00:00:00

abstract：:Deacetylation is a rapid clearance mechanism for ocular melatonin. We have studied the distribution of retinal melatonin deacetylase activity among vertebrate classes. Exogenous radiolabeled melatonin is metabolized by ocular tissue prepared from the amphibian Xenopus laevis, the reptile Anolis carolinensis, the teleo...

journal_title：Brain research

authors： Grace MS,Cahill GM,Besharse JC

更新日期：1991-09-13 00:00:00

abstract：:Changes in the expression and activation of protein kinase C (PKC) have been implicated in the pathogenesis of diabetic neuropathy. Recent studies in liver, retina, and cardiovascular tissues from experimentally diabetic rats have demonstrated that diabetes has a selective effect on the expression and subcellular dist...

journal_title：Brain research

authors： Roberts RE,McLean WG

更新日期：1997-04-18 00:00:00

abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...

journal_title：Brain research

authors： Sopp MR,Michael T,Mecklinger A

更新日期：2018-11-01 00:00:00

abstract：:Non-specific convulsive behavior induced by intrathecal (IT) morphine microinjection appears to be tonically modulated by centrifugal pathways originating within the brain since the frequency of IT morphine-induced hindlimb seizures and myoclonic twitches are both increased following spinal transection. These effects ...

journal_title：Brain research

authors： Watkins LR,Frenk H,Miller J,Mayer DJ

更新日期：1984-09-24 00:00:00

abstract：:In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...

journal_title：Brain research

authors： Leung PC,Whitmoyer DI,Arendash GW,Sawyer CH

更新日期：1981-12-07 00:00:00

abstract：:Our study aimed to explore the influence of two different stressors: acute (once for 15 min) and chronic (15 min daily for 21 days) exposure to high light open field (HL-OF) or forced swim (FS) on the density of nerve growth factor (NGF) and tyrosine kinase A (TrkA) immunoreactive neurons in the hippocampal CA1 and CA...

journal_title：Brain research

authors： Badowska-Szalewska E,Spodnik E,Klejbor I,Ludkiewicz B,Moryś J

更新日期：2011-04-12 00:00:00

abstract：:Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...

journal_title：Brain research

authors： Brody KM,Taylor JM,Wilson GR,Delatycki MB,Lockhart PJ

更新日期：2008-03-27 00:00:00

abstract：:The recent development of rodent models of bone cancer pain has started to provide the basis for demonstrating the particular neurochemical and behavioral entity of cancer pain. Behaviourally, both spontaneous pain and hyperalgesia related to mechanical, but not thermal, noxious stimuli have been described in cancer-b...

journal_title：Brain research

authors： Menéndez L,Lastra A,Fresno MF,Llames S,Meana A,Hidalgo A,Baamonde A

更新日期：2003-04-18 00:00:00

abstract：:Dural afferent neurons are implicated in primary headaches including migraine. Although a significant portion of primary afferent neurons innervating the dura are myelinated A-type neurons, previous electrophysiological studies have primarily characterized the functional properties of small-sized C-type sensory neuron...

journal_title：Brain research

authors： Nakamura M,Jang IS

更新日期：2018-10-01 00:00:00

abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...

journal_title：Brain research

authors： Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

更新日期：1991-11-01 00:00:00

abstract：:An extensive exploration of the discriminating properties of olfactory receptors cells has been conducted in our laboratory through the statistical processing of single cell responses recorded in the frog's olfactory epithelium. Similarities between odorant stimulating properties could be demonstrated by comparing the...

journal_title：Brain research

authors： Sicard G,Holley A

更新日期：1984-02-06 00:00:00

abstract：:Field potentials and radial current source-densities (CSDs) evoked by optic tract stimulation were observed in goldfish tectum in vitro. The effects of different concentrations of calcium and magnesium were studied to improve understanding of component events in retinotectal transmission and interpretations of effects...

journal_title：Brain research

authors： Langdon RB,Manis PB,Freeman JA

更新日期：1988-02-16 00:00:00

abstract：:Elevations in the plasma levels of glucocorticoids are associated with cognitive impairments that have been ascribed to loss of neurons in the hippocampal formation. However, recent studies have strongly challenged this view. In order to clarify this issue, we have employed for the first time the optical fractionator ...

journal_title：Brain research

authors： Sousa N,Madeira MD,Paula-Barbosa MM

更新日期：1998-06-01 00:00:00

abstract：:Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by ...

journal_title：Brain research

authors： McCarthy MM

更新日期：2011-03-16 00:00:00

abstract：:There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...

journal_title：Brain research

authors： Elmes SJ,Millns PJ,Smart D,Kendall DA,Chapman V

更新日期：2004-10-01 00:00:00

abstract：:Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

journal_title：Brain research

authors： McNeill TH,Brown SA,Rafols JA,Shoulson I

更新日期：1988-07-05 00:00:00

abstract：:This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...

journal_title：Brain research

authors： Crago RV,Renoult L,Biggart L,Nobes G,Satmarean T,Bowler JO

更新日期：2019-11-15 00:00:00

abstract：:Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce thei...

journal_title：Brain research

authors： Commons KG

更新日期：2010-02-16 00:00:00