Abstract：
:Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enzyme ascorbic acid oxidase (AAO), the primary signal contribution has been calculated to come from ascorbic acid. By inhibiting monoamine oxidase activity with pargyline, the second most important contributor in caudate extracellular fluid is postulated to be 3,4-dihydroxyphenylacetic acid. These species are calculated to constitute over 93% of the observed oxidation current in rat caudate extracellular fluid.
journal_name
Brain Resjournal_title
Brain researchauthors
Schenk JO,Miller E,Rice ME,Adams RNdoi
10.1016/0006-8993(83)90901-0subject
Has Abstractpub_date
1983-10-24 00:00:00pages
1-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)90901-0journal_volume
277pub_type
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