Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons.

Abstract:

:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), and (+)-5-ethyl-5-(1,3-dimethylbutyl) barbituric acid [+)-DMBB), and the sedative barbiturate, 5-ethyl-5-(3-methylbutyl) barbituric acid (3MB), all potentiated GABA-mediated chloride currents. In addition, these compounds prolonged the duration of GABAergic inhibitory postsynaptic currents. The similarity between the action of convulsant and sedative barbiturates suggests that the convulsant activity of 3M2B and (+)-DMBB are not mediated by their actions at GABAergic synapses.

journal_name

Brain Res

journal_title

Brain research

authors

Holland KD,Canney DJ,Rothman SM,Ferrendelli JA,Covey DF

doi

10.1016/0006-8993(90)90910-4

subject

Has Abstract

pub_date

1990-05-14 00:00:00

pages

147-50

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(90)90910-4

journal_volume

516

pub_type

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