Abstract:
:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), and (+)-5-ethyl-5-(1,3-dimethylbutyl) barbituric acid [+)-DMBB), and the sedative barbiturate, 5-ethyl-5-(3-methylbutyl) barbituric acid (3MB), all potentiated GABA-mediated chloride currents. In addition, these compounds prolonged the duration of GABAergic inhibitory postsynaptic currents. The similarity between the action of convulsant and sedative barbiturates suggests that the convulsant activity of 3M2B and (+)-DMBB are not mediated by their actions at GABAergic synapses.
journal_name
Brain Resjournal_title
Brain researchauthors
Holland KD,Canney DJ,Rothman SM,Ferrendelli JA,Covey DFdoi
10.1016/0006-8993(90)90910-4subject
Has Abstractpub_date
1990-05-14 00:00:00pages
147-50issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90910-4journal_volume
516pub_type
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