Abstract：
:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, the apoptosis regulatory genes B-cell leukemia-2 (Bcl-2) and Bcl-2-associated X protein (Bax) may be involved in the neuroprotective process. In this study, 120 Wistar rats were randomly divided into three groups (sham, I/R-induced, and propofol-treated). Cerebral ischemia was induced by clamping the bilateral common carotid arteries for 10min. Propofol (1.0mg/kg/min) was administered intravenously for 1h before the induction of ischemia. Neuronal damage was evaluated by neurobehavioral scores and histological examination of the brain sections at the level of the dorsal hippocampus at 6h, 24h, 48h, 72h, 4days, 5days, 6days, and 7days after I/R. The apoptotic rate of hippocampal neurons was detected by flow cytometry. The expression of Bcl-2 and Bax was evaluated using immunohistochemical and Western blot methods. The results of this study showed that neurobehavioral scores were higher in propofol-treated rats compared with I/R-induced rats with no propofol treatment. Moreover, the hippocampal expression of Bcl-2 was significantly higher, while the expression of Bax was significantly lower in propofol-treated rats compared with I/R-induced rats at 24h after ischemia. Hence, this study suggests that the neuroprotective effects of propofol against neuronal apoptosis may be a consequence of the regulation of Bcl-2 and Bax.
journal_name
Brain Resjournal_title
Brain researchauthors
Xi HJ,Zhang TH,Tao T,Song CY,Lu SJ,Cui XG,Yue ZYdoi
10.1016/j.brainres.2011.06.060subject
Has Abstractpub_date
2011-09-02 00:00:00pages
24-32eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01231-5journal_volume
1410pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In the neonatal kitten, cuneate neurones activated by tactile stimulation of the forelimb foot pads are divisible into 3 functional classes each of which appears to receive its glabrous skin input selectively from a single class of tactile receptors. Their properties suggest that the functionally specific patterns of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90081-x
更新日期：1981-06-01 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00860-9
更新日期：1998-11-02 00:00:00
abstract：:In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.034
更新日期：2013-11-06 00:00:00
abstract：:The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.103
更新日期：2009-11-03 00:00:00
abstract：:Responses elicited by stimulating the pre-versus postganglionic nerves were compared in cat bladder parasympathetic neurons. We observed that synaptic potentials recorded on stimulating the postganglionic nerve trunk were different from those elicited with preganglionic nerve stimulation. These findings suggest that l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91634-9
更新日期：1987-12-01 00:00:00
abstract：:Rats were exposed to 1.3 gHz microwave energy to assess the uptake of several neutral polar substances in certain areas of the brain. A quantitative, radioactive isotope method, which uses an internal standard, was employed to measure the loss of test substances to brain tissue. Single, 20 min exposure, to either puls...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90726-0
更新日期：1977-05-06 00:00:00
abstract：:The nicotine and muscarinic responses of differentiated mouse neuroblastoma cells from the clonal line N1E 115 to applied cholinergic agents were recorded using single channel and whole cell patch clamp techniques. An inward macroscopic current induced by acetylcholine (ACh) at the resting potential was blocked by cur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91252-7
更新日期：1986-11-19 00:00:00
abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.001
更新日期：2012-06-06 00:00:00
abstract：:For the purpose of obtaining chemical information about the physiological role of N-acetylaspartylglutamate (NAAG), the release of endogenous NAAG from and the uptake of [3H]NAAG by Guinea pig cerebellar slices were investigated in comparison with L-aspartate (Asp) and L-glutamate (Glu). Although endogenous NAAG was f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90544-1
更新日期：1989-03-13 00:00:00
abstract：PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.041
更新日期：2016-10-01 00:00:00
abstract：:Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03117-2
更新日期：2003-09-26 00:00:00
abstract：:Ultrastructural localization of a calcium-binding protein, calretinin, in the cerebellar cortex of the rat was examined with an immunoperoxidase method. The cerebellar lobule V was investigated in detail. In the molecular layer, calretinin immunoreactivity was found in parallel fibers and in their varicosities that fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90915-a
更新日期：1993-06-11 00:00:00
abstract：:[1-14C]Octanoate (OCTO) is rapidly extracted from blood and metabolized by brain. Up to 6 min following an intravenous pulse injection the autoradiographic pattern of brain labeling reflects differences in blood flow and energy metabolism. When animals are given OCTO during visual or somatosensory stimulation the auto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90486-x
更新日期：1985-06-03 00:00:00
abstract：:NMDA receptor (NMDAR) antagonists such as ketamine, can reproduce many of the symptoms of schizophrenia. A reliable indicator of NMDAR channel blocker action in vivo is the augmentation of neuronal oscillation power. Since the coordinated and rhythmic activation of neuronal assemblies (oscillations) is necessary for p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146571
更新日期：2020-01-15 00:00:00
abstract：:Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia. Degradation of HIF is regulated under normoxia by oxygen-dependent hydroxylation of specific prolyl residues on the labile alpha-subunit by HIF prolyl hydroxylases (PHD). Prolyl-4...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.023
更新日期：2009-07-14 00:00:00
abstract：:Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrilla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90914-0
更新日期：1987-07-28 00:00:00
abstract：:Intracisternal (i.c.) administration of the glutamate-receptor antagonist kynurenate to halothane-anesthetized rats (paralyzed, ventilated) produced an initial hypertension associated with an increase in lumbar sympathetic nerve discharge. Kynurenate (i.c.) blocked or greatly reduced all sympathetic reflexes investiga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91320-0
更新日期：1988-01-12 00:00:00
abstract：:In recent years microvillar cells (MVC) have been identified in the olfactory epithelium of numerous species, including rodents, canines, and primates. However, there is no consensus on the morphologic or histochemical features of this cell, nor is the function of these cells currently known. Previous studies have exa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01144-7
更新日期：1995-01-09 00:00:00
abstract：:The localization of the receptor for apamin, a specific toxin for one class of sensitive Ca2+-dependent K+ channel, was studied in rat brain using an in vitro autoradiographic technique. Radiolabeled monoiodoapamin binds specifically to rat brain sections with a high affinity (Kd = 25 pM) to a single class of sites. A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91333-8
更新日期：1986-09-24 00:00:00
abstract：:The distribution of neural elements immunoreactive to several peptides with a possible messenger role was studied in the lamprey spinal cord by using an indirect immunofluorescence method. Different patterns of immunoreactive (IR) fibers were detected by antisera raised against cholecystokinin, metorphamide, bombesin,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90392-1
更新日期：1987-04-07 00:00:00
abstract：:The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1984-09-10 00:00:00
abstract：:Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.058
更新日期：2009-04-10 00:00:00
abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90676-z
更新日期：1992-02-07 00:00:00
abstract：:A subpopulation of astrocytes in periventricular regions of aging brain and in cysteamine (CSH)-treated glial cultures contain autofluorescent cytoplasmic granules that exhibit an affinity for Gomori's chrome alum hematoxylin (CAH), and non-enzymatic peroxidase activity. Although shown to be histochemically distinct f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91125-c
更新日期：1993-06-25 00:00:00
abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00654-9
更新日期：1997-08-08 00:00:00
abstract：:The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90798-r
更新日期：1993-09-17 00:00:00
abstract：:The supracommissural ventral telencephalon and the medial preoptic area have been shown to play important roles in the sexual behavior of himé salmon (landlocked red salmon, Oncorhynchus nerka). In the present study, the sites of neurons projecting to these regions were examined by means of the retrograde horseradish ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91286-7
更新日期：1985-12-30 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02585-x
更新日期：2003-06-27 00:00:00
abstract：:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90036-8
更新日期：1987-12-01 00:00:00
abstract：:In alert monkeys, some prefrontal neurons located in the superior dorsolateral area were activated to acoustic stimuli delivered in a restricted range of directions with respect to the animal's head. The effective direction was usually contralateral to the animal. The function of the auditory neurons in connection to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91434-3
更新日期：1984-04-30 00:00:00
