Abstract:
:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+]o) and calcium ([Ca2+]o) were made during these spontaneous epileptiform events, using ion-sensitive electrodes. Individual interictal spikes were associated with [Ca2+]o decreases of 0.1-0.2 mM, whereas sustained ictal-like discharges were accompanied by decreases of 0.3-0.4 mM. Measurement of [K+]o showed that individual interictal spikes were associated with increases in [K+]o up to 12 mM, whereas increases to more than 20 mM accompanied long-lasting ictal-like discharges. Maximum increases in [K+]o were observed ca. 600 microns below the pial surface. [K+]o increases were followed by undershoots of the resting [K+]o level. The unusually high [K+]o levels associated with epileptiform discharges in the immature neocortex suggest that disturbances in [K+]o regulation may contribute to the generation of the picrotoxin-induced, spontaneous, prolonged ictal-like discharges observed in the 8- to 15-day age group.
journal_name
Brain Resjournal_title
Brain researchauthors
Hablitz JJ,Heinemann Udoi
10.1016/0165-3806(87)90036-8subject
Has Abstractpub_date
1987-12-01 00:00:00pages
299-303issue
2eissn
0006-8993issn
1872-6240journal_volume
433pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Excitatory and inhibitory synapses may control neuronal output through a push-pull mechanism--that is, increases in excitation are coupled to simultaneous decreases in inhibition or vice versa. This pattern of activity is characteristic of excitatory and inhibitory vestibulospinal axons that mediate vestibulocollic re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.065
更新日期:2010-05-28 00:00:00
abstract::Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferenc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90737-x
更新日期:1981-01-26 00:00:00
abstract::Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90318-h
更新日期:1993-11-12 00:00:00
abstract::Intracerebral administration of 6-hydroxydopamine (6-HDA) along the dorsal noradrenergic bundle produced a gradual and long-lasting decrease of norepinephrine (NE) in hippocampus. This decrease in NE levels initially was accompanied by a parallel decrease in the activity of the rate-limiting enzyme for NE biosynthesis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90056-8
更新日期:1984-12-24 00:00:00
abstract::The present in vitro study was performed to characterize neurons within dorsal regions of the nucleus tractus solitarii (NTS), principally at the level of area postrema, and known to receive inputs predominantly from cardiovascular and respiratory afferents (i.e. cardiorespiratory NTS). This report describes 4 classes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90358-t
更新日期:1993-02-26 00:00:00
abstract::The functional role of many central nervous structures has been inferred from the temporal relationship of a neuronal response with the different sensory and motor events in an experimental design such as when an animal performs a trained movement in response to a conditioned stimulus. However, this kind of data analy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90279-2
更新日期:1983-11-14 00:00:00
abstract::This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02379-9
更新日期:2000-07-14 00:00:00
abstract::Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91262-7
更新日期:1980-01-06 00:00:00
abstract::Serotonin (5HT) is thought to reset the biological clock in the suprachiasmatic nuclei (SCN) in vitro through a postsynaptic 5HT-1a receptor. Thus we examined 5HT receptor gene expression in the SCN by in situ hybridization. On film autoradiograms, 5HT-1c receptor mRNA showed intense SCN hybridization, while 5HT-1b re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90789-p
更新日期:1993-04-09 00:00:00
abstract::The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90098-3
更新日期:1986-09-03 00:00:00
abstract::The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02412-9
更新日期:2000-02-21 00:00:00
abstract::Using a co-culture model, we showed that diffusible factors from arcuate nucleus (AN) specifically increased the number and the size of hypothalamic neurons producing melanin-concentrating hormone (MCH). In this model neurite outgrowth and contacts between MCH neurons and dopaminergic neurons were also prominently inc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90948-m
更新日期:1993-11-19 00:00:00
abstract::Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (LI) and dopamine D2 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.01.058
更新日期:2012-04-04 00:00:00
abstract::Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00053-5
更新日期:1998-04-20 00:00:00
abstract::The vascular changes in the hippocampus and neocortex during kainic acid-induced seizures were investigated in control rats and in rats with chronic, bilateral, cervical sympathectomy. Seizures were induced in unanesthetized, spontaneously breathing rats. The increase in blood flow in the hippocampus of the sympathect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91782-c
更新日期:1990-11-05 00:00:00
abstract::The neural representation of facial expression within the human visual system is not well defined. Using an adaptation paradigm, we examined aftereffects on expression perception produced by various stimuli. Adapting to a face, which was used to create morphs between two expressions, substantially biased expression pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.104
更新日期:2007-01-05 00:00:00
abstract::The extrafusal and intrafusal muscle fibers in the masseter muscle are innervated by motoneurons in the trigeminal motor nucleus (Mo 5). In the present study, we found that the number of trigeminal motor neurons in the male mouse was significantly larger than that in the female. However, we could not detect any signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90763-d
更新日期:1993-11-05 00:00:00
abstract::Compound action potential recording techniques were used to investigate the time- and frequency-dependent effects of 4-aminopyridine (4-AP) and tetraethylammonium (TEA) on large diameter, fast conducting (t1) and medium diameter, middle conducting (t2) optic tract axons in anesthetized hooded rats. Single-pulse studie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91102-5
更新日期:1989-10-02 00:00:00
abstract::Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90244-6
更新日期:1990-08-27 00:00:00
abstract::Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00720-3
更新日期:1998-09-21 00:00:00
abstract::The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90287-2
更新日期:1985-05-27 00:00:00
abstract::Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the anterior hypothalamic area (AHA) was studied in 15 bats which are seasonal hibernators, using the unlabeled antibody enzyme method of Sternberger. Our results showed that the density of immunoreactive fibers and terminal plexuses in the AHA was great...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91422-9
更新日期:1988-02-16 00:00:00
abstract::Results of studies with rodents have shown that animals repeatedly injected with the opioid antagonist, naloxone, acquire a hypoalgesic response to thermal nociceptive stimuli. The present study revealed a similar response in the terrestrial pulmonate snail, Cepaea nemoralis. Snails receiving daily injections of nalox...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90285-u
更新日期:1993-08-20 00:00:00
abstract::The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90180-4
更新日期:1983-11-21 00:00:00
abstract::In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01625-x
更新日期:1999-07-31 00:00:00
abstract::Brainstem noradrenergic neurons located in the A5, A6, and A7 catecholamine cell groups provide the entire noradrenergic innervation of the spinal cord. We have previously demonstrated that noradrenergic neurons in the A6 and A7 cell groups innervate the ventral and dorsal horns, respectively. Since the specific spina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90210-e
更新日期:1993-07-09 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro. BDNF deficiency may play a role in Parkinson's disease, as the surviving dopaminergic nigrostriatal neurons have reduced level...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.052
更新日期:2005-03-28 00:00:00
abstract::The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02862-1
更新日期:2001-10-19 00:00:00
abstract::Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.033
更新日期:2011-05-16 00:00:00
abstract::Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02599-4
更新日期:2002-06-14 00:00:00