Abstract：
PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter of the temporal lobe in patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Sixty patients with NPC who had normal MRI brain scans were enrolled and underwent DKI at 1 week (n=20), 6 months (n=20) or 1 year (n=20) after radiotherapy; 20 normal control individuals were also evaluated. Nonlinear fitting routines and equations were used to calculate mean diffusion (MD) and mean kurtosis (MK) and fractional anisotropy (FA). Analysis of variance was used to compare the MK/MD/FA values of white and grey matter between groups. RESULTS:Compared to the normal control group, grey and white matter MK values were significantly higher at 1 week after radiotherapy and significantly lower at 6 months and 1 year after radiotherapy in patients with NPC, whereas the grey and white matter MD values were significantly lower at 1 week after radiotherapy and returned to normal by 6 months and 1 year after radiotherapy. CONCLUSION:DKI can be used to detect radiotherapy-induced changes in both the white and grey matter of temporal lobe in patients with NPC. MK and MD values may represent reliable indicators for the early diagnosis of radiation-induced temporal lobe changes in NPC.
journal_name
Brain Resjournal_title
Brain researchauthors
Wang D,Li YH,Fu J,Wang Hdoi
10.1016/j.brainres.2016.07.041subject
Has Abstractpub_date
2016-10-01 00:00:00pages
387-393issue
Pt Aeissn
0006-8993issn
1872-6240pii
S0006-8993(16)30532-7journal_volume
1648pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. To compare and further understand the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91391-9
更新日期：1994-05-30 00:00:00
abstract：:The present study was designed to examine the trophic effect of sympathetic nerves on cerebrovascular hypertrophy in developmental hypertension. Unilateral superior cervical ganglionectomy was performed in spontaneously hypertensive rats at 4 weeks of age, and wall-to-lumen ratios of cerebral arteries were determined ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90772-9
更新日期：1986-08-06 00:00:00
abstract：:Strong evidence obtained from in vivo and ex-vivo studies suggests the existence of interaction between dopaminergic and nitrergic systems. Some of the observations suggest a possible implication of nitric oxide (NO) in dopamine (DA) uptake mechanism. The present work investigated the interaction between both systems ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.12.054
更新日期：2008-03-10 00:00:00
abstract：:Amyloid-beta protein (A beta) deposition in the cerebral vascular walls is one of the key features of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). A beta(1-40) carrying the 'Dutch' mutation (HCHWA-D A beta(1-40)) induces pronounced degeneration of cultured human brain p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03218-3
更新日期：2002-10-11 00:00:00
abstract：:The time courses for development of neuronal and behavioral tolerance to diazepam (DZ) were estimated in rats continuously exposed to low levels of DZ for 3, 7, 14 or 21 days. Microiontophoretic sensitivity of dorsal raphe neurons to gamma-aminobutyric acid (GABA) was initially facilitated after short-term exposure to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90993-0
更新日期：1987-03-03 00:00:00
abstract：:During the re-entrainment of the rat pineal N-acetyltransferase (NAT) rhythm to an 8-h advance of a light-dark (LD) cycle accomplished by shortening of one dark period, the advanced light period phase-delayed the evening NAT rise and phase-advanced the morning decline. The phase-relationship between the rise and the d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90605-7
更新日期：1989-08-14 00:00:00
abstract：:Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.035
更新日期：2018-11-15 00:00:00
abstract：:Response conflict can be induced by priming multiple responses competing for control of action in trials. The N2 is one functionally-related cognitive control index for response conflict. And yet the underlying whiter matter neural substrates of inter-individual difference in conflict N2 remain unclear. So the aim of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.008
更新日期：2017-12-01 00:00:00
abstract：:The neocortex in chronically prepared rats is very resistant to the induction of long-term potentiation (LTP). In the first of two experiments described in this paper, we tried unsuccessfully to induce neocortical LTP within one session by coactivating basal forebrain cholinergic and cortical inputs to our neocortical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01025-0
更新日期：1995-12-08 00:00:00
abstract：:Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91227-8
更新日期：1990-09-03 00:00:00
abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：:The possibility of a functional relationship between noradrenaline and neurohypophyseal peptides in the control of cardiovascular function in the nucleus tractus solitarius of rats has been investigated. The hypotensive response to microinjections of noradrenaline (20 nmol) was abolished by simultaneous (but not prior...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90936-x
更新日期：1987-10-06 00:00:00
abstract：:The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but not the extrapyramidal basal gangl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90083-7
更新日期：1987-02-17 00:00:00
abstract：:Post traumatic stress disorder (PTSD) is characterised by hyperarousal, anxiety and amnesic symptoms. Deficits in explicit memory recall have been causally related to volume reductions of the hippocampus and prefrontal cortex. While stress-related glucocorticoid secretion appears involved in this apparent atrophy, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03033-6
更新日期：2003-09-05 00:00:00
abstract：:Results of studies with rodents have shown that animals repeatedly injected with the opioid antagonist, naloxone, acquire a hypoalgesic response to thermal nociceptive stimuli. The present study revealed a similar response in the terrestrial pulmonate snail, Cepaea nemoralis. Snails receiving daily injections of nalox...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90285-u
更新日期：1993-08-20 00:00:00
abstract：:In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.030
更新日期：2016-03-15 00:00:00
abstract：:Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90628-9
更新日期：1991-10-25 00:00:00
abstract：:Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91312-3
更新日期：1992-10-16 00:00:00
abstract：:The monoamine levels in the locus coeruleus (LC) were determined by HPLC following specific lesions of the ventral mesencephalic tegmental-A10 regions (VMT-A10) and raphé dorsalis (RD). Only lesions in the VMT-A10 area decreased the dopamine (DA) content, which strongly suggests that the projection from this region to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90327-x
更新日期：1983-03-21 00:00:00
abstract：:The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.084
更新日期：2009-05-19 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.071
更新日期：2007-07-23 00:00:00
abstract：:Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90818-g
更新日期：1991-12-20 00:00:00
abstract：:Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.051
更新日期：2004-08-20 00:00:00
abstract：:An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90049-3
更新日期：1981-10-01 00:00:00
abstract：:Using nerve growth factor (NGF), anti-NGF sera and dissociated neonatal mouse dorsal root ganglionic neurons we present a microculture assay methodology for (1) the titration of neurotrophic factor (NTF) activity in monolayer culture, (2) the titration of NTF antibodies which 'block' NTF biological activity, (3) the t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90408-x
更新日期：1981-12-28 00:00:00
abstract：:To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong G...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.090
更新日期：2006-03-29 00:00:00
abstract：:In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90424-3
更新日期：1982-11-04 00:00:00
abstract：:In chloralose-urethane anaesthetized cats and in one unanesthetized decerebrate cat, the possibility of a baroreceptor pathway exerting an inhibitory effect directly on the sympathetic preganglionic neurone (SPN) was examined. Stimulation of excitatory points in the brain stem and spinal cord evoked responses in T3 wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90212-2
更新日期：1981-09-07 00:00:00
abstract：:Rats with hippocampal dialysis probes were treated with DL-fenfluramine (FEN), fluoxetine, or FEN with fluoxetine pre-treatment. FEN (12.5 mg/kg) increased extracellular serotonin (5-HT) from 0.4 +/- 0.04 to 25.2 +/- 4.16 pg/10 microliters. Fluoxetine (10.0 mg/kg) increased extracellular 5-HT levels from 0.4 +/- 0.05 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91249-e
更新日期：1992-07-10 00:00:00
