Abstract：
:In chloralose-urethane anaesthetized cats and in one unanesthetized decerebrate cat, the possibility of a baroreceptor pathway exerting an inhibitory effect directly on the sympathetic preganglionic neurone (SPN) was examined. Stimulation of excitatory points in the brain stem and spinal cord evoked responses in T3 white ramus (T3WR) which could be markedly depressed (80-100%) by raising the pressure in an isolated carotid sinus. Conditioning-testing experiments indicated that the onset of this inhibition had a long latency (100-250 msec). Responses in T3WR evoked by stimulating both 'fast' (5 m/sec) and 'slow' (2-3 m/sec) bulbospinal pathways were similarly affected by baroreceptor stimulation. This inhibition could be much reduced (40-100%) by topical application to T3 segment of phentolamine (1-2 microgram). Baroreceptor activation also caused a complete cessation of the discharge evoked by microelectrophoretic application of glutamate to single antidromically identified SPN. The data support the suggestion of a direct action on SPN of a bulbospinal baroreceptor inhibitory pathway.
journal_name
Brain Resjournal_title
Brain researchauthors
Coote JH,Macleod VH,Fleetwood-Walker SM,Gilbey MPdoi
10.1016/0006-8993(81)90212-2subject
Has Abstractpub_date
1981-09-07 00:00:00pages
81-93issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(81)90212-2journal_volume
220pub_type
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