Abstract:
:As a model of chronic inflammatory pain, Freund's adjuvant-induced polyarthritis has been shown to be associated with marked alterations in the activity of opioid- and calcitonin gene-related peptide (CGRP)-containing neurons in the dorsal horn of the spinal cord in rats. Possible changes in the interactions between these two peptidergic systems in chronic inflammatory pain were investigated by comparing the effects of various opioid receptor ligands on the spinal outflow of CGRP-like material (CGRPLM) in polyarthritic and age-paired control rats. Intrathecal perfusion of an artificial cerebrospinal fluid in halothane-anaesthetized animals allowed the collection of CGRPLM released from the spinal cord and the application of opioid receptor ligands. The blockade of kappa-opioid receptors similarly increased CGRPLM release in both groups of rats as expected of a kappa-mediated tonic inhibitory control of CGRP-containing fibres in control, as well as in polyarthritic rats. In contrast, the higher increase in CGRPLM outflow due to the preferential blockade of mu opioid receptors by naloxone in polyarthritic rats as compared to non-suffering animals supports the idea of a reinforced mu opioid receptor-mediated tonic inhibitory control of CGRP-containing fibres in rats suffering from chronic pain. Even more strikingly, the differences observed in the effects of delta-opioid receptor ligands on CGRPLM outflow suggest that delta receptors are functionally shifted from a participation in a phasic excitatory control in non-suffering rats to a tonic inhibitory control in polyarthritic rats. These data indicate that agonists acting at the three types of opioid receptors all exert a tonic inhibitory influence on CGRP-containing nociceptive primary afferent fibres within the spinal cord of polyarthritic rats. Such a convergence probably explains why morphine and other opioids are especially potent to reduce pain in subjects suffering from chronic inflammatory diseases.
journal_name
Brain Resjournal_title
Brain researchauthors
Ballet S,Mauborgne A,Benoliel JJ,Bourgoin S,Hamon M,Cesselin F,Collin Edoi
10.1016/s0006-8993(98)00350-3subject
Has Abstractpub_date
1998-06-15 00:00:00pages
198-208issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00350-3journal_volume
796pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Several neurodevelopmental disorders, including schizophrenia, autism, ADD/ADHD and dyslexia are believed to originate during gestation and involve white matter abnormalities. Modulation of glutamate environments and glutamate receptors has also been implicated in alteration of oligodendrocytes, the myelin forming cel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.126
更新日期:2008-10-09 00:00:00
abstract::The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90407-2
更新日期:1980-09-08 00:00:00
abstract::Effect of a mu-opioid agonist (D-Ala2,N-MePhe4,Gly5-ol-enkephalin, DAGO), on glycine (Gly)-induced chloride current (IGly) was investigated in the periaqueductal gray (PAG) neurons acutely dissociated 1-2-week-old Wistar rats by the use of nystatin-perforated patch recording configuration under voltage-clamp condition...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-09-23 00:00:00
abstract::There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.005
更新日期:2004-10-01 00:00:00
abstract::The retinoblastoma protein (pRb) is a key regulator of cell growth, differentiation and survival. pRb(-/-) mice show abnormal neuronal cell death in the developing brain. The function of pRb is regulated by its phosphorylation state. In this study, the phosphorylation of pRb during retinoic acid (RA)-induced neuronal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01844-2
更新日期:1999-09-25 00:00:00
abstract::Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We have previously demonstrated that a phosphorothioate antisense ODN to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00463-0
更新日期:1997-08-08 00:00:00
abstract::Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90345-v
更新日期:1991-08-02 00:00:00
abstract::Methylenedioxymethamphetamine (MDMA, Ecstasy) is a powerful releaser of serotonin. Increasing recreational use of this stimulant and hallucinogenic drug has raised concerns about its potential to produce brain damage. The vast majority of previous research studies have focused on the compound's ability to deplete sero...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02563-0
更新日期:2003-06-06 00:00:00
abstract::We assessed the chronological change of the expression of synaptophysin, an integral glycoprotein on the presynaptic vesicles, after a transient cerebral ischemic insult in the rat. The ischemic lesion was consistently localized in the dorsolateral part of the striatum, which was clearly visualized by a depletion of c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90225-c
更新日期:1993-07-09 00:00:00
abstract::We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01505-9
更新日期:1998-03-16 00:00:00
abstract::Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91498-h
更新日期:1993-04-02 00:00:00
abstract::The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91297-e
更新日期:1991-04-05 00:00:00
abstract::A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03032-9
更新日期:2002-09-20 00:00:00
abstract::Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91337-e
更新日期:1992-08-14 00:00:00
abstract::Choroid plexuses from the lateral (LVCP) and fourth ventricles (FVCP) of rats or rabbits were incubated in artificial cerebrospinal fluid (CSF) containing 1 microM [14C]L-carnitine with various concentrations of L-carnitine ranging from 0.01 mM to 1.0 mM. The time course of 1 microM [14C]L-carnitine uptake by the chor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90188-2
更新日期:1991-07-19 00:00:00
abstract::By means of the [14C]deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in the lateral geniculate nucleus and the superior colliculus of rats with a simultaneous double enucleation, animals with an enucleation of the right eye between neonatal and adult stages followed by an enucleation of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90688-4
更新日期:1989-05-29 00:00:00
abstract::Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, and exerts CB1-mediated central antinociception in the mouse tail-flick assay. The aim of the present study was to further investigate the analgesic properties of supraspinal mouse VD-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.12.013
更新日期:2018-02-01 00:00:00
abstract::Much evidence suggests that the neuropeptide cholecystokinin (CCK) functions as a neurotransmitter or neuromodulator in the central nervous system. The CCKa receptor subtype in the nucleus accumbens has been demonstrated to potentiate the behavioral and neurophysiological effects of dopamine. Since the mesolimbic dopa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00918-g
更新日期:1995-11-20 00:00:00
abstract::Our previous studies have demonstrated that a mixture of bovine brain gangliosides ( BBG ) applied to Neuro-2a neuroblastoma cells markedly increased the degree and rate of neurite formation. In the present study, the cytoskeletal basis for BBG -mediated neurite outgrowth was investigated by comparing cells grown in t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90075-0
更新日期:1984-03-01 00:00:00
abstract::Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Studies reported in this paper...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90552-9
更新日期:1985-03-11 00:00:00
abstract::Immunohistochemical studies in rats have demonstrated dopaminergic input onto medium spiny neurons of the striatum. Medium spiny neurons, however, are known to consist of two major neuropeptide-specific types, those containing substance P (SP) and those containing enkephalin. Although both of these types have been sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90490-z
更新日期:1992-02-14 00:00:00
abstract::The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2015.07.034
更新日期:2015-12-02 00:00:00
abstract::5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the regional density of binding to 5-HT receptors and transporters and the l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02055-7
更新日期:1999-11-13 00:00:00
abstract::Anticonvulsant mood stabilizers, e.g., valproic acid and carbamazepine, and atypical antipsychotic drugs (APDs), e.g., clozapine, quetiapine, olanzapine, risperidone, and ziprasidone, have been reported to preferentially increase dopamine (DA) release in rat medial prefrontal cortex (mPFC), an effect partially or full...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.05.005
更新日期:2005-07-12 00:00:00
abstract::Administration of non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists (e.g. phencyclidine, MK-801) has been shown to elicit behavioral abnormalities related to symptoms of schizophrenia, such as spontaneous locomotor activity and impaired sensorimotor gating, as represented by deficits of prepulse inhibit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.013
更新日期:2010-09-17 00:00:00
abstract::The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02988-3
更新日期:2003-08-15 00:00:00
abstract::In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02824-4
更新日期:2001-10-05 00:00:00
abstract::Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90941-2
更新日期:1985-12-09 00:00:00
abstract::In addition to synaptic remodeling, formation of new neurons is increasingly acknowledged as an important cue for plastic changes in the central nervous system. Whereas all vertebrates retain a moderate neuroproliferative capacity, phylogenetically younger mammals become dramatically impaired in this potential during ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.026
更新日期:2010-05-12 00:00:00
abstract::The mismatch negativity is an electrophysiological marker of auditory change detection in the event-related brain potential and has been proposed to reflect an automatic comparison process between an incoming stimulus and the representation of prior items in a sequence. There is evidence for two main functional subcom...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.079
更新日期:2008-07-18 00:00:00