Abstract：
:We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synaptic potentials mediated by N-methyl-d-aspartate (NMDA) receptors in the dentate gyrus of rat hippocampal slices. Synaptic potential mediated by non-NMDA receptors was recorded in normal medium (1.3 mM Mg2+), while NMDA receptor-mediated synaptic potential was isolated in low (0.13 mM) Mg2+ medium containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (10 microM). Crocin (10 microM) alone did not affect synaptic potentials mediated by non-NMDA nor NMDA receptors. Non-NMDA response was slightly inhibited by 100 mM ethanol, while NMDA response was selectively inhibited by lower concentrations (10-50 mM) of ethanol. Crocin (10 microM) did not affect the inhibition of non-NMDA response by 100 mM ethanol, but significantly blocked the inhibition of NMDA response by 10-50 mM ethanol. In addition, we performed whole-cell patch recording with primary cultured rat hippocampal neurons, and confirmed that crocin blocked ethanol inhibition of inward currents evoked by application of NMDA. These results suggest that crocin specifically antagonizes the inhibitory effect of ethanol on NMDA receptor-mediated responses in hippocampal neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Abe K,Sugiura M,Shoyama Y,Saito Hdoi
10.1016/s0006-8993(97)01505-9subject
Has Abstractpub_date
1998-03-16 00:00:00pages
132-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01505-9journal_volume
787pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Somatosensory evoked potentials (SEP) recorded from humans were elicited by a cutaneous shock to the index finger or with a ramp displacement of the finger that stretched the first dorsal interosseous muscle. A somatosensory stimulus was presented while a subject maintained a steady posture of the metacarpophalangeal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91068-8
更新日期：1989-09-04 00:00:00
abstract：:c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02943-8
更新日期：2002-09-06 00:00:00
abstract：:Rats were exposed to 1.3 gHz microwave energy to assess the uptake of several neutral polar substances in certain areas of the brain. A quantitative, radioactive isotope method, which uses an internal standard, was employed to measure the loss of test substances to brain tissue. Single, 20 min exposure, to either puls...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90726-0
更新日期：1977-05-06 00:00:00
abstract：:This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00755-0
更新日期：1998-09-21 00:00:00
abstract：:Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.014
更新日期：2015-11-19 00:00:00
abstract：:The present study reveals developmental changes in the number, the phenotype and the distribution pattern of mast cells (MCs) along the cervical, the thoracic and the lumbar parts of the spinal dura mater. Postnatal infiltration of spinal dura by MCs does not appear to follow a sequential developmental pattern and men...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.057
更新日期：2008-08-21 00:00:00
abstract：:The vascular changes in the hippocampus and neocortex during kainic acid-induced seizures were investigated in control rats and in rats with chronic, bilateral, cervical sympathectomy. Seizures were induced in unanesthetized, spontaneously breathing rats. The increase in blood flow in the hippocampus of the sympathect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91782-c
更新日期：1990-11-05 00:00:00
abstract：:Tritiated thymidine ([3H]TdR) autoradiography revealed a correlation between the rate of cell proliferation of rod precursor cells in the outer nuclear layer (ONL) of the goldfish retina and the postoperative interval after crush of the optic nerve (ONC). Ten days after unilateral ONC there were more labeled nuclei in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90642-2
更新日期：1989-11-06 00:00:00
abstract：:The present study investigated differences between vestibulo-somatic and vestibulo-sympathetic reflexes, along with differences between somatic and autonomic spino-bulbo-spinal (SBS) reflexes in chloralose-urethane anesthetized cats. Electrical stimulation was applied to the vestibular nerve (V) for a duration of 0.3 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90221-5
更新日期：1985-05-20 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
abstract：:These experiments examined the effects, on retention, of posttraining intra-amygdala administration of norepinephrine (NE), and propranolol. Rats were trained on a one-trial step-through inhibitory avoidance task and tested for retention 24 h later. Injections were administered bilaterally (1.0 microliter/injection) t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91049-8
更新日期：1986-03-12 00:00:00
abstract：:The ability of hippocampal serotonergic (5-HT) axons to proliferate in response to damage by para-chloroamphetamine (PCA) was examined in this study. Synaptosomal uptake of 5-HT in the hippocampal formation was decreased to 40% of control 3 days after systemic administration of PCA. Six weeks after PCA, uptake values ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90281-d
更新日期：1992-04-17 00:00:00
abstract：:The activity of cerebellar Purkinje cells during controlled and passive movement of the forepaw was studied in the cat. Burst responses characteristic of activation by climbing fibers were observed in Purkinje cells in lobules Vb and Vc of the cerebellar vermis and paravermis. The climbing fiber responses followed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90069-x
更新日期：1976-04-16 00:00:00
abstract：:The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91037-2
更新日期：1991-02-15 00:00:00
abstract：:Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90089-5
更新日期：1981-04-27 00:00:00
abstract：:Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91425-g
更新日期：1990-04-30 00:00:00
abstract：:To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00524-t
更新日期：1995-08-14 00:00:00
abstract：:The aim of this work was to characterize the interaction of the Na+-channel toxin, purified from venom of the scorpion Leiurus quinquestriatus, with microtubule proteins in vitro. The toxin enhanced microtubule assembly, causing the formation of microtubule 'bundles'. It interacted with the Na+-channel 270 kDa subunit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90019-7
更新日期：1986-07-01 00:00:00
abstract：:It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.019
更新日期：2011-01-25 00:00:00
abstract：:We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.103
更新日期：2006-07-12 00:00:00
abstract：:The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91244-b
更新日期：1990-09-03 00:00:00
abstract：:This neuroimaging study investigated the neural mechanisms of the effect of conversation on visual event detection during a driving-like scenario. The static load paradigm, established as predictive of visual reaction time in on-road driving, measured reaction times to visual events while subjects watched a real-world...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.002
更新日期：2009-01-28 00:00:00
abstract：:The specific benzodiazepine antagonist, Ro14-7437, in nanomolar concentrations, caused depolarization, increased spontaneous spiking, and conductance decrease when applied to CA1 cells in vitro. These effects were resistant to intracellularly injected Cl- ions or synaptic blockade by TTX, were prevented in Ca2+-free m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91370-7
更新日期：1983-07-18 00:00:00
abstract：:Certain developmental abnormalities have been associated with environmental exposure to lead and our previous studies have indicated that the endogenous opioid system is disrupted by this metal. In connection with this we report the ontogeny of proenkephalin products in the rat striatum determined by combined HPLC and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90070-7
更新日期：1985-09-01 00:00:00
abstract：:Ischemic insults affecting the internal capsule result in sensory-motor disabilities which adversely affect the patient's life. Cerebral endothelial cells have been reported to exert a protective effect against brain damage, so the transplantation of healthy endothelial cells might have a beneficial effect on the outc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.042
更新日期：2012-08-21 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.063
更新日期：2004-03-19 00:00:00
abstract：:The effects of 0.1 to 500 mM ethanol on NMDA-activated currents were studied in primary cultures of mouse cortical and hippocampal neurons. In whole-cell recordings the IC50S for inhibition of NMDA-activated currents by ethanol were 129 mM +/- 20 mM in hippocampal neurons and 126 +/- 18 mM in cortical neurons. In sing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00780-9
更新日期：1996-11-04 00:00:00
abstract：:The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphism...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03849-0
更新日期：2003-01-24 00:00:00
abstract：:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01953-8
更新日期：1999-12-18 00:00:00
abstract：:The neurotoxic effects of chronic ethanol exposure were investigated in rat hippocampus by electrophysiological analysis of the Schaffer collateral-commissural input to stratum radiatum of CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special diet at leas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90777-0
更新日期：1981-09-28 00:00:00
