当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Effects of extrinsic autonomic inputs on expression of c-Fos immunoreactivity in myenteric neurons of the guinea pig distal colon.

Effects of extrinsic autonomic inputs on expression of c-Fos immunoreactivity in myenteric neurons of the guinea pig distal colon.

Abstract：

:c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enteric circuits. No c-Fos immunoreactivity was observed in the colonic segments fixed immediately after removal from the animal body. A number of c-Fos-immunoreactive nuclei of myenteric neurons, however, appeared in all preparations that were incubated in Krebs solution in vitro (n=10). Application of tetrodotoxin (0.2 microM) abolished the expression of c-Fos-immunoreactivity (n=6), but hexamethonium (100 microM) failed to decrease the number of c-Fos-positive neurons despite a complete suppression of spontaneous peristaltic movements (n=5). Neither the electrical stimulation (n=8) nor the severing of the pelvic nerves (n=5) changed the number of c-Fos-positive neurons. Application of clonidine, an alpha(2)-agonist, (0.1 microM) abolished the expression of c-Fos protein in all preparations (n=5), while denervation of the sympathetic fibers in the lumbar colonic and hypogastric nerves in vivo increased the number of c-Fos-positive neurons (n=5). The results indicate that the enteric circuit in the distal part of the gastrointestinal tract is under tonic inhibition by the sympathetic nervous system from the lumbar spinal cord. c-Fos immunoreactivity expressed in the colonic preparations in vivo might be the results of enhanced activation of non-nicotinic receptors after removal of the sympathetic inhibition.

journal_name

Brain Res

journal_title

Brain research

authors

Yuyama N,Mizuno J,Tsuzuki H,Wada-Takahashi S,Takahashi O,Tamura K

doi

10.1016/s0006-8993(02)02943-8

subject

Has Abstract

pub_date

2002-09-06 00:00:00

pages

8-16

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899302029438

journal_volume

948

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Carbachol-induced rhythmic slow activity (theta) in cat hippocampal formation slices.

    abstract：:Application of the cholinergic agonist, carbachol, produced theta-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus in the cat hippocampal formation slices. This effect of carbachol was antagonized by atropine but not D-tubocurarine. These results provide first direct evidence that the...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90223-v

    authors： Konopacki J,Gołebiewski H,Eckersdorf B

    更新日期：1992-04-24 00:00:00

  • Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.

    abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)03243-2

    authors： Parsey RV,Oquendo MA,Simpson NR,Ogden RT,Van Heertum R,Arango V,Mann JJ

    更新日期：2002-11-08 00:00:00

  • Processing symbolic and non-symbolic proportions: Domain-specific numerical and domain-general processes in intraparietal cortex.

    abstract：:Previous studies on the processing of fractions and proportions focused mainly on the processing of their overall magnitude information in the intraparietal sulcus (IPS). However, the IPS is also associated with domain-general cognitive functions beyond processing overall magnitude, which may nevertheless be involved ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.02.029

    authors： Mock J,Huber S,Bloechle J,Bahnmueller J,Moeller K,Klein E

    更新日期：2019-07-01 00:00:00

  • Multiple sclerosis: immunochemical studies on the demyelinating serum factor.

    abstract：:Sera from patients with multiple sclerosis (MS) frequently produce demyelination of central nervous system tissue cultures. The nature of the factors responsible for demyelination is not as yet clearly established. However, several authors previously reported, in in vivo and in vitro models, demyelinating activity in ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(79)91075-8

    authors： Grundke-Iqbal I,Bornstein MB

    更新日期：1979-01-19 00:00:00

  • Postural change and straining induced by distension of the rectum, vagina and urinary bladder of decerebrate dogs.

    abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90223-4

    authors： Fukuda H,Fukai K

    更新日期：1986-08-20 00:00:00

  • Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex.

    abstract：:The use of two different radioligands, [125I]Leu8, D-Tryp22,Tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125I]204-090, D-Phe-Cys[125I]Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. In homogenates, octapeptide somato...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90813-4

    authors： Reubi JC,Probst A,Cortés R,Palacios JM

    更新日期：1987-03-17 00:00:00

  • The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines.

    abstract：:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)01318-c

    authors： Pesold C,Treit D

    更新日期：1995-02-13 00:00:00

  • p75 and TrkA receptors are both required for uptake of NGF in adult sympathetic neurons: use of a novel fluorescent NGF conjugate.

    abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)03099-2

    authors： Gatzinsky KP,Haugland RP,Thrasivoulou C,Orike N,Budi-Santoso AW,Cowen T

    更新日期：2001-11-30 00:00:00

  • Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons.

    abstract：:Glutamate kills sensitive neurons through several steps downstream to receptor activation: increased free Ca2+ levels, activation of various enzymes and accumulation of reactive oxygen species (ROS). We have evaluated in a well established model of neuronal cultures the neuroprotective effects of blocking these mechan...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：

    authors： Ciani E,Grøneng L,Voltattorni M,Rolseth V,Contestabile A,Paulsen RE

    更新日期：1996-07-22 00:00:00

  • Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement.

    abstract：:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02379-9

    authors： Foster TC,Fugger HN,Cunningham SG

    更新日期：2000-07-14 00:00:00

  • Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection.

    abstract：:Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2005.07.003

    authors： Xu M,Yip GW,Gan LT,Ng YK

    更新日期：2005-09-07 00:00:00

  • Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans.

    abstract：:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...

    journal_title：Brain research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-8993(96)01268-1

    authors： Wright KP Jr,Badia P,Myers BL,Plenzler SC,Hakel M

    更新日期：1997-01-30 00:00:00

  • Dopaminergic modulation of striatal neuropeptides: differential effects of D1 and D2 receptor stimulation on somatostatin, neuropeptide Y, neurotensin, dynorphin and enkephalin.

    abstract：:Dopaminergic modulation of neuropeptides in rat striatum was investigated by examining the effects of prolonged D1 or D2 receptor stimulation on levels of somatostatin, neuropeptide Y, neurotensin, dynorphin and enkephalin. Rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway were trea...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90716-m

    authors： Engber TM,Boldry RC,Kuo S,Chase TN

    更新日期：1992-05-29 00:00:00

  • Growth hormone (GH), thyroid-stimulating hormone (TSH), and luteinizing hormone (LH)-like peptides in the rodent brain: non-parallel ontogenetic development with pituitary counterparts.

    abstract：:Brain and anterior pituitary growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) were measured during fetal, neonatal, and pubertal life and into adulthood. Immunoassayable GH and TSH could be found in the fetal whole brain before their detection in the fetal pituitary. Developmental pa...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(82)90186-9

    authors： Hojvat S,Emanuele N,Baker G,Connick E,Kirsteins L,Lawrence AM

    更新日期：1982-08-01 00:00:00

  • Postnatal development of acetylcholinesterase in the caudate-putamen nucleus and substantia nigra of rats.

    abstract：:The postnatal development of acetylcholinesterase (AChE, EC 3.1.1.7) and NADH-diaphorase was examined in the caudate-putamen nucleus and substantia nigra of rats ranging from 3 to 90 days in age. From 3 to 15 days post partum islands of AChE and NADH-diaphorase activity were observed in the caudate-putamen nucleus. In...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)91022-2

    authors： Butcher LL,Hodge GK

    更新日期：1976-04-23 00:00:00

  • Comparison of [125I]-bolton-hunter substance P binding in young and aged rat spinal cord.

    abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)01463-7

    authors： Maguire CM,Geraghty DP

    更新日期：1998-03-09 00:00:00

  • Spindle gain increase during muscle unit fatigue.

    abstract：:In anaesthetized cats, medial gastrocnemius motor units (MUs) were stimulated with random sequences (mean rates between 6 and 12 pps) of electrical pulses delivered to their axons in small ventral root filaments. Muscle tension was recorded under isometric conditions, and spike trains of muscle spindle afferents were ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)91656-2

    authors： Christakos CN,Windhorst U

    更新日期：1986-02-19 00:00:00

  • Rostral and caudal ventricular infusion of antibodies to dynorphin A(1-17) and dynorphin A(1-8): effects on electrically-elicited feeding in the rat.

    abstract：:Lateral ventricular injection of antibodies to dynorphin A(1-13) was previously shown to elevate lateral hypothalamic stimulation frequency threshold for eliciting feeding behavior. The antibodies utilized in that study cross-react completely with dynorphin A(1-17) and, to a lesser extent, dynorphin A(1-8). In the pre...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90284-i

    authors： Carr KD,Bak TH

    更新日期：1990-01-22 00:00:00

  • The role of plantar cutaneous mechanoreceptors in the control of compensatory stepping reactions evoked by unpredictable, multi-directional perturbation.

    abstract：:The role of plantar pressure sensation in controlling compensatory stepping was explored via hypothermic anesthesia of the foot soles, in 10 healthy young adults. Stepping reactions were evoked by unpredictable platform translation in forward, backward and lateral directions. The findings suggest three specific direct...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02712-8

    authors： Perry SD,McIlroy WE,Maki BE

    更新日期：2000-09-22 00:00:00

  • Differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant single sodium channels.

    abstract：:The differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) single sodium channel currents in rat dorsal root ganglion (DRG) neurons were investigated using the outside-out configuration of patch-clamp technique. Channel conductances were 10.7 and 6.3 pS...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)01449-7

    authors： Song JH,Narahashi T

    更新日期：1996-03-18 00:00:00

  • Increased [3H]glutamate receptor binding in aged rats.

    abstract：:Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(81)90823-4

    authors： Baudry M,Arst DS,Lynch G

    更新日期：1981-10-26 00:00:00

  • Impairment of long-term potentiation and paired-pulse facilitation in rat hippocampal dentate gyrus following developmental lead exposure in vivo.

    abstract：:Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations of long-term potentiation (LTP) and paired-pulse facilitation (PPF) of hippocampal dentate gyrus in adult rats (90-115 days) following developmental lead exposure were studied in viv...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00739-2

    authors： Ruan DY,Chen JT,Zhao C,Xu YZ,Wang M,Zhao WF

    更新日期：1998-09-28 00:00:00

  • Ornithine decarboxylase activity in rat intestinal mucosa and liver is stimulated by central administration of 2-deoxy-D-glucose but not of 2,5-anhydro-D-mannitol.

    abstract：:It has been shown that 2-deoxy-D-glucose (2-DG) inhibits glucose utilization and elicits feeding through the lateral hypothalamus. In contrast, 2,5-anhydro-D-mannitol (2,5-AM), blocking glycogenolysis and/or gluconeogenesis, elicits feeding through the ventromedial hypothalamus. The aim of the present study was to det...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(96)00138-2

    authors： Morita H,Fujimoto K,Sakata T,Kurokawa M,Yoshimatsu H,Noda T,Iwakiri R,Sakai T

    更新日期：1996-05-06 00:00:00

  • Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols.

    abstract：:The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2020.146798

    authors： Dumont U,Sanchez S,Olivier B,Chateil JF,Deffieux D,Quideau S,Pellerin L,Beauvieux MC,Bouzier-Sore AK,Roumes H

    更新日期：2020-07-01 00:00:00

  • Pineal nitric oxide synthase: characteristics, adrenergic regulation and function.

    abstract：:Available studies indicate that the adrenergic stimulation of pineal cyclic GMP production involves stimulation of guanylyl cyclase activity by nitric oxide (NO) derived from arginine. This line of investigation was extended in the present study. Using a highly sensitive microassay, it was found that pineal NO synthas...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)90693-9

    authors： Lin AM,Schaad NC,Schulz PE,Coon SL,Klein DC

    更新日期：1994-07-18 00:00:00

  • Effect of opioids on acetylcholine release evoked by K+ or glutamic acid from rat neostriatal slices.

    abstract：:Endogenous acetylcholine (ACh) release from rat striatal slices was measured by a chemiluminescent method. Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU). Morphine, [D-Ala2,Gly(0l)5]-enkephalin (DAGO), [D-Ala2,D-Leu5]-enkephalin (DADLE) ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91633-r

    authors： Arenas E,Alberch J,Sanchez Arroyos R,Marsal J

    更新日期：1990-07-16 00:00:00

  • Glycine response in isolated dorsal cochlear nucleus of C57BL/6J mouse.

    abstract：:Pharmacological properties of glycine (Gly)-induced Cl- current (ICl) in the dorsal cochlear nucleus (DCN) neurons acutely dissociated from C57BL/6J mouse were investigated in the whole-cell configuration of the patch-clamp technique. Gly-induced ICl increased in a sigmoidal manner with higher Gly concentrations. Stry...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90794-a

    authors： Kakehata S,Nakagawa T,Takasaka T,Akaike N

    更新日期：1992-03-06 00:00:00

  • Quantitative analysis of glutamic acid decarboxylase-immunoreactive neurons in the anterior thalamus of the human brain.

    abstract：:Local circuit neurons in the human anterior thalamus (AT) were identified on the basis of glutamic acid decarboxylase immunoreactivity (GAD-IR). GAD-IR neurons of the AT displayed small diameter somas with thin, sparsely-branching dendrites, consistent with the morphological characteristics of local circuit neurons fo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)03194-8

    authors： Dixon G,Harper CG

    更新日期：2001-12-27 00:00:00

  • Tyrosine hydroxylase expression within Balb/C and C57black/6 mouse locus coeruleus. I. Topological organization and phenotypic plasticity of the enzyme-containing cell population.

    abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(96)00074-1

    authors： Ginovart N,Marcel D,Bezin L,Garcia C,Gagne C,Pujol JF,Weissmann D

    更新日期：1996-05-20 00:00:00

  • Stability of cell size and nucleolar size in tangle-bearing neurons of the hippocampus in Alzheimer's disease.

    abstract：:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90843-3

    authors： Gertz HJ,Schoknecht G,Krüger H,Cervos-Navarro J

    更新日期：1989-05-22 00:00:00