Abstract：
:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Light Caffeine. The Dim Light-Caffeine condition (200 mg twice each night) relative to the Dim Light-Placebo condition suppressed nighttime melatonin levels and attenuated the normal decrease in temperature. Combining caffeine ingestion with bright light exposure (> or = 2000 lux) suppressed melatonin and attenuated the normal nighttime drop in temperature to a larger degree than either condition alone; i.e. effects were additive. Circadian effects were also observed in that the amplitude and phase of the temperature rhythm were altered during treatment. These findings establish that the human melatonin system is responsive to caffeine. Other evidence suggests that caffeine may influence melatonin and temperature levels through antagonism of the neuromodulator adenosine.
journal_name
Brain Resjournal_title
Brain researchauthors
Wright KP Jr,Badia P,Myers BL,Plenzler SC,Hakel Mdoi
10.1016/s0006-8993(96)01268-1subject
Has Abstractpub_date
1997-01-30 00:00:00pages
78-84issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01268-1journal_volume
747pub_type
临床试验,杂志文章,随机对照试验相关文献
BRAIN RESEARCH文献大全abstract：:The aim of the present study was to investigate the effects of ischemic preconditioning on infarct volume in a rat model of subdural hematoma (SDH). Ischemic preconditioning was induced by 15 min transient middle cerebral artery (MCA) occlusion followed 3 days later by the injection of 300 microl of autologous venous ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03406-0
更新日期：2002-03-15 00:00:00
abstract：:Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91097-7
更新日期：1984-06-03 00:00:00
abstract：:Multidrug efflux transporters of the ATP-Binding cassette (ABC) family, P-glycoprotein (Pgp), multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature play important roles in limiting movement of substances into and enhancing th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.034
更新日期：2010-10-28 00:00:00
abstract：:Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.078
更新日期：2004-05-08 00:00:00
abstract：:The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.068
更新日期：2004-11-26 00:00:00
abstract：:Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90184-8
更新日期：1994-02-04 00:00:00
abstract：:Hippocampal slices were taken from 7-day-old rats and maintained in vitro for 1-3 weeks. The organization of intrahippocampal connections in these explants was studied by placing onto the tissue small crystals of horseradish peroxidase (HRP) soaked with the detergent Nonidet. Antero- and retrograde transport of HRP wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91448-4
更新日期：1986-08-13 00:00:00
abstract：:The nigrostriatal projection was studied with a retrograde tracing method (Evans blue, EB) combined with a technique for dopamine histofluorescence. The study, realized in control rats and in animals with 6-hydroxydopamine-induced lesions of the dopaminergic pathway, yielded the following results. (1) In 3 control rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90235-3
更新日期：1981-06-01 00:00:00
abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.058
更新日期：2015-02-19 00:00:00
abstract：:We sought to identify the areas that have altered neuronal activity within the hypothalamus of rats with heart failure (HF) by mapping neuronal staining of c-Fos protein (Fos) 6-8 weeks following coronary artery ligation (HF group; n=17) or sham surgery (sham-operated control group, n=15). Fos-like immunoreactivity wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02186-7
更新日期：2000-05-19 00:00:00
abstract：:The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90200-3
更新日期：1986-06-25 00:00:00
abstract：:Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal dopamine determined by quantitative microdialysis (the no net flux method) when castrated and ovariectomized rats were c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91225-h
更新日期：1993-04-30 00:00:00
abstract：:Transiently increased immunoreactivity of the calcium binding protein S-100beta was demonstrated in spinal ganglion nerve cells after sciatic nerve transection. Neuropeptide Y (NPY), normally not seen in these nerve cells, appeared concomitantly. The transiently elevated co-expression of S-100beta and NPY is proposed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01425-x
更新日期：1998-03-02 00:00:00
abstract：:Systemic administration of 3-nitropropionic acid (3-NP) results in striatal atrophy by irreversibly inhibiting the citric acid cycle, and thereby resulting in cellular ATP depletion. The neuropathological outcome following 3-NP injections is thought to resemble that seen in Huntington's disease (HD) [1]. The current s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90085-x
更新日期：1994-05-23 00:00:00
abstract：:More than 50% of the Xenopus pectoralis twitch muscle fibers with two distant endplates are innervated at both sites by the same neuron. This study indicates that there are three separable twitch motor unit types in this muscle which show very little overlap in innervation. This study also shows that each motor unit i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90697-3
更新日期：1985-03-25 00:00:00
abstract：:Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.057
更新日期：2007-09-26 00:00:00
abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91560-1
更新日期：1994-01-07 00:00:00
abstract：:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.037
更新日期：2015-03-10 00:00:00
abstract：:In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90763-2
更新日期：1985-09-23 00:00:00
abstract：:We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01563-1
更新日期：1998-03-16 00:00:00
abstract：:Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.07.098
更新日期：2006-12-18 00:00:00
abstract：:In male hamsters mating behavior is dependent on chemosensory input from the main olfactory and vomeronasal systems, whose central pathways contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH) neurons. In sexually naive males, vomeronasal organ removal (VNX), but not main olfactory lesions, impairs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.078
更新日期：2010-03-04 00:00:00
abstract：:Electrophysiological studies have suggested that the excitatory actions of opioids in the hippocampal formation are mediated by inhibition of interneurons containing GABA; however, an anatomical basis for this interaction has never been established. Thus, we sought to determine the relationship between leu-enkephalin ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00236-3
更新日期：1996-06-10 00:00:00
abstract：:The conditioned place preference paradigm was used to study the reinforcing properties of D-amphetamine. Rats were injected (i.p.) with D-amphetamine sulphate (0.5, 1.0 or 5.0 mg/kg) and 10 min later confined for 30 min to one side of a shuttle box in which each of the two compartments had distinctive features. On alt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90685-0
更新日期：1982-12-16 00:00:00
abstract：:Perfusion of hippocampal slices with normoxic medium containing no added sodium resulted in a rapid loss of the CA1 population spike, with only 35 +/- 10% (S.E.M.) (P < 0.001) recovery after a 15 min exposure. This injury was prevented by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (93 +/- 4% rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91464-p
更新日期：1992-11-06 00:00:00
abstract：:A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.014
更新日期：2007-12-05 00:00:00
abstract：:Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.03.036
更新日期：2019-08-15 00:00:00
abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.057
更新日期：2009-08-11 00:00:00
abstract：:Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.068
更新日期：2011-08-02 00:00:00
abstract：:Metabolites formed from testosterone in the brain, their neuroanatomical distribution and the kinetic properties of the enzymes were studied in male and female Japanese quail chicks and compared with the adult brain using an in vitro radioassay. Oestradiol-17 beta. 5 alpha-dihydrotestosterone, 5 beta-dihydrotestostero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90149-5
更新日期：1986-02-01 00:00:00
