Spindle gain increase during muscle unit fatigue.

Abstract:

:In anaesthetized cats, medial gastrocnemius motor units (MUs) were stimulated with random sequences (mean rates between 6 and 12 pps) of electrical pulses delivered to their axons in small ventral root filaments. Muscle tension was recorded under isometric conditions, and spike trains of muscle spindle afferents were recorded from small dorsal root filaments during prolonged MU activation. Time-domain (PSTH) and frequency-domain (gain) computations were performed to study the effects of fatiguing muscle unit contractions on the signal transmission from skeletomotor efferents to spindle afferents. In the course of muscle unit fatigue, during which the gain of the force-producing sub-system decreased, the gain of the sub-system transforming force to afferent discharge increased so that the overall gain between skeletomotor efferents and spindle afferents remained relatively high. This could be a mechanism that preserves a high quality of afferent information on MU contractions.

journal_name

Brain Res

journal_title

Brain research

authors

Christakos CN,Windhorst U

doi

10.1016/0006-8993(86)91656-2

subject

Has Abstract

pub_date

1986-02-19 00:00:00

pages

388-92

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)91656-2

journal_volume

365

pub_type

杂志文章
  • Lesions of the accessory olfactory bulb decrease lordotic responsiveness and reduce mating-induced c-fos expression in the accessory olfactory system.

    abstract::The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90902-4

    authors: Dudley CA,Moss RL

    更新日期:1994-04-11 00:00:00

  • Studies on the control of myelinogenesis. 3. Signalling of oligodendrocyte myelination by regenerating peripheral axons.

    abstract::Continuing from earlier work which demonstrated the peripheral axonal regulation of Schwann cell myelination, this study has investigated the possibility that a peripheral axon can stimulate oligodendrocyte myelination. To test this hypothesis, regenerating PNS axons were allowed to interact with uncommitted oligodend...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90289-0

    authors: Weinberg EL,Spencer PS

    更新日期:1979-02-23 00:00:00

  • Attentional modulation of repetition attenuation is anatomically dissociable for scenes and faces.

    abstract::Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.01.090

    authors: Yi DJ,Kelley TA,Marois R,Chun MM

    更新日期:2006-03-29 00:00:00

  • How are the motor system activity and functional connectivity between the cognitive and sensorimotor systems modulated by athletic expertise?

    abstract::Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.09.048

    authors: Tomasino B,Maieron M,Guatto E,Fabbro F,Rumiati RI

    更新日期:2013-12-02 00:00:00

  • An endogenous ligand of the brain sigma/PCP receptor antagonizes NMDA-induced neurotransmitter release.

    abstract::The present study provides evidence for the presence of an endogenous ligand for the phencyclidine (PCP) receptor of mammalian brain. Partially purified bovine hippocampal extracts potently and dose dependently inhibit binding to PCP receptors of [3H]N-(1-[2-thienyl]-cyclohexyl)piperidine (TCP), a highly potent and sp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91499-5

    authors: Zukin SR,Zukin RS,Vale W,Rivier J,Nichtenhauser R,Snell LD,Johnson KM

    更新日期:1987-07-21 00:00:00

  • Fluoro-Gold: composition, and mechanism of uptake.

    abstract::Determining the mechanism by which fluorescent retrograde neuronal tracers are taken up requires knowledge of their composition. It has been claimed that Fluoro-Gold, a retrogradely transported fluorescent neuronal tracer, is 2-hydroxy-4,4'-diamidinostilbene (hydroxystilbamidine), an amidine antibiotic. However, this ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90241-m

    authors: Wessendorf MW

    更新日期:1991-07-05 00:00:00

  • Two distinct types of transient outward currents in area postrema neurons in rat brain slices.

    abstract::We investigated the electrophysiological properties of the area postrema neurons in acutely prepared rat brain slices using the whole-cell patch-clamp technique. Two different types of transient outward potassium current (I(to)), fast and slow, were found in the area postrema. Both the decay time constant and rise tim...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02651-3

    authors: Funahashi M,Mitoh Y,Matsuo R

    更新日期:2002-06-28 00:00:00

  • RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic-ischemic brain injury in rats.

    abstract::The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04149-5

    authors: Ma L,Carter RJ,Morton AJ,Nicholson LF

    更新日期:2003-03-21 00:00:00

  • Nicotine-mediated plasticity in robust nucleus of the archistriatum of the adult zebra finch.

    abstract::Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a v...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.051

    authors: Salgado-Commissariat D,Rosenfield DB,Helekar SA

    更新日期:2004-08-20 00:00:00

  • Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain synaptic membranes.

    abstract::Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91729-z

    authors: Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

    更新日期:1990-06-18 00:00:00

  • Expression of the immediate-early gene egr-1 and substance P in the spinal cord following locomotor training in adult rats.

    abstract::The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.041

    authors: Nunes AC,Duarte RB,Sousa TB,dos Santos JR,Freire MA,Costa MS

    更新日期:2010-07-23 00:00:00

  • Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation.

    abstract::Several lines of evidence support a role for nerve growth factor (NGF) in the sympathetic sprouting response that occurs following septal cholinergic denervation of the rat hippocampal formation. The present study was undertaken to compare the distribution of NGF-like immunoreactivity and the topography of sympathetic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)01344-h

    authors: Yu C,Crutcher KA

    更新日期:1995-02-20 00:00:00

  • Focal elevations in neocortical interstitial K+ produced by stimulation of the fastigial nucleus in rat.

    abstract::We studied whether K+, a potent cerebrovasodilator released by active neurons, participates in the increase in cortical cerebral blood flow (CBF) elicited by stimulation of the cerebellar fastigial nucleus (FN). Rats were anesthetized by continuous administration of halothane (1-3%), paralyzed and artificially ventila...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91544-b

    authors: Iadecola C,Kraig RP

    更新日期:1991-11-01 00:00:00

  • Upregulation of the brainstem preproglucagon system in the obese Zucker rat.

    abstract::A group of neurons in the caudal nucleus of the solitary tract (NTS) processes preproglucagon to glucagon-like peptide 1 (GLP-1), GLP-2 and oxyntomodulin. Whereas the anorectic capacity of all three neuropeptides has been demonstrated, only relatively little is known of preproglucagon mRNA regulation in the brain stem...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.10.026

    authors: Vrang N,Larsen PJ,Jensen PB,Lykkegaard K,Artmann A,Larsen LK,Tang-Christensen M

    更新日期:2008-01-02 00:00:00

  • Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis.

    abstract::Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.06.029

    authors: Rashad S,Niizuma K,Sato-Maeda M,Fujimura M,Mansour A,Endo H,Ikawa S,Tominaga T

    更新日期:2018-11-15 00:00:00

  • Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography.

    abstract::Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01315-2

    authors: Kessler M,Mutneja MS,Rogers G,Lynch G

    更新日期:1998-02-02 00:00:00

  • Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding.

    abstract::Two selectively bred lines of mice, one responding with high (HA) and the other with low analgesia (LA) to 3 min swims at 20 degrees C were compared with respect to naloxone ability to reverse such swim induced pain threshold elevation. Also, the analgesic effect of morphine was tested in both lines of mice. Naloxone ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91380-6

    authors: Panocka I,Marek P,Sadowski B

    更新日期:1986-11-05 00:00:00

  • Post-transcriptional regulation of loss of rat striatal D2 dopamine receptor during aging.

    abstract::The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibod...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90095-q

    authors: Sakata M,Farooqui SM,Prasad C

    更新日期:1992-03-20 00:00:00

  • Sexual dimorphism in the preoptic/anterior hypothalamic area of ferrets: effects of adult exposure to sex steroids.

    abstract::The organization of neuronal cell bodies in the caudal preoptic area (POA) and rostral anterior hypothalamic area (AH) was studied in Nissl-stained brain sections from adult male and female ferrets. Computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90837-1

    authors: Tobet SA,Zahniser DJ,Baum MJ

    更新日期:1986-02-05 00:00:00

  • Role of anterior pretectal nucleus in somatosensory cortical descending modulation of jaw-opening reflex in rats.

    abstract::Both the somatosensory cerebral cortex and anterior pretectal nucleus (APT) have been shown to produce descending modulation of trigeminal (V) and spinal somatosensory neurone and reflex activities. Since the APT receives a direct projection from the somatosensory cortex, experiments were performed to compare the effe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90599-7

    authors: Chiang CY,Dostrovsky JO,Sessle BJ

    更新日期:1990-05-07 00:00:00

  • A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological states.

    abstract::Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90782-4

    authors: Cremer JE,Ray DE,Sarna GS,Cunningham VJ

    更新日期:1981-09-28 00:00:00

  • Studies on cellular toxicity of bilirubin: effect on brain glycolysis in the young rat.

    abstract::(1) The levels of glycolytic intermediates in the brain tissue of 15-day-old homozygous and heterozygous Gunn rats were determined with or without novobiocin treatment in vivo, and the inhibitory effects of bilirubin on the glycolytic activity and the key glycolytic enzyme activities were investigated in vitro. (2) t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90945-8

    authors: Katoh-Semba R

    更新日期:1976-08-27 00:00:00

  • Adenosine A1 receptor-mediated depression of corticostriatal and thalamostriatal glutamatergic synaptic potentials in vitro.

    abstract::Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01060-3

    authors: Flagmeyer I,Haas HL,Stevens DR

    更新日期:1997-12-05 00:00:00

  • Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum.

    abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146968

    authors: Almeida LEF,Wang L,Kamimura S,Zerfas PM,Smith ML,Neto OLA,Vale T,Quezado MM,Horkayne-Szakaly I,Wakim P,Quezado ZMN

    更新日期:2020-11-01 00:00:00

  • Effects of monocular enucleation at different stages of development on the uncrossed retinocollicular projection in the opossum.

    abstract::Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(86)90236-1

    authors: Méndez-Otero R,Rocha-Miranda CE,Carvalho-Dias E

    更新日期:1986-06-01 00:00:00

  • Effects of repetitive transcranial magnetic stimulation (rTMS) on attribution of movement to ambiguous stimuli and EEG mu suppression.

    abstract::Recent research suggests that attributing human movement to ambiguous and static Rorschach stimuli (M responses) is associated with EEG mu suppression, and that disrupting the left inferior gyrus (LIFG; a putative area implicated in mirroring activity) decreases the tendency to see human movement when exposed to the R...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.12.007

    authors: Ando' A,Pineda JA,Giromini L,Soghoyan G,QunYang,Bohm M,Maryanovsky D,Zennaro A

    更新日期:2018-02-01 00:00:00

  • Differential response of hippocampal and prefrontal oscillations to systemic LPS application.

    abstract::The early electrophysiological phenomena linked to systemic inflammation are largely underexplored. We developed here local field analyses to detect prodromal oscillatory abnormalities. We identified early band-specific patterns in local field potential recorded from freely-moving rats injected intraperitoneally with ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.12.036

    authors: Mamad O,Islam MN,Cunningham C,Tsanov M

    更新日期:2018-02-15 00:00:00

  • Effects of phencyclidine administration on behavior and brain neurotensin-like immunoreactivity in rats.

    abstract::The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91601-4

    authors: Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita O

    更新日期:1985-05-06 00:00:00

  • The role of nitric oxide in the neuropathology in soman intoxication.

    abstract::Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91296-3

    authors: Bouchaud C,Chollat-Namy A,Duserre S,Delamanche IS

    更新日期:1994-10-17 00:00:00

  • Botulinum A toxin and tetanus toxin do not affect presynaptic membrane currents in mammalian motor nerve endings.

    abstract::The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90617-0

    authors: Dreyer F,Mallart A,Brigant JL

    更新日期:1983-07-04 00:00:00