Abstract：
:The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its relationship with LTP is still scarce. The substance P (SP) has also been associated with LTP in the dorsal horn of the spinal cord following high frequency stimulation. Here we evaluated the expression of both Egr-1 and SP in the sacrolumbar area of the spinal cord after locomotor training in adult rats. Increased neuronal Egr-1 expression was found in the spinal cord sections in rats that underwent locomotor training, especially in laminae IV and X across L3-S4 levels (p<0.05). Conversely, SP expression in synaptic terminals was not altered in the abovementioned regions. Our results suggest that locomotor training activates mechanisms in a similar way to LTP, and is involved in the synaptic plasticity in the spinal cord. The results also indicate that variations in the training protocol influence Egr-1 expression. Such events appear not to be directly influenced by SP, which suggests a plastic process that differs from those triggered by nociceptive stimuli.
journal_name
Brain Resjournal_title
Brain researchauthors
Nunes AC,Duarte RB,Sousa TB,dos Santos JR,Freire MA,Costa MSdoi
10.1016/j.brainres.2010.05.041subject
Has Abstractpub_date
2010-07-23 00:00:00pages
125-36eissn
0006-8993issn
1872-6240pii
S0006-8993(10)01186-8journal_volume
1345pub_type
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