Abstract：
:gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze avoidance task induced a dose-dependent deficit in retention performance 48 h later. gamma-LGLA had no effect on locomotor activity or emotional reactivity at the doses used. Separate or simultaneous administration of aspartate or glutamate (each at 250 nmol/kg) had no effect on learning retention, indicating that deficit induced by gamma-LGLA was specific to the peptide. gamma-LGLA impaired learning acquisition in a time-dependent manner when administered from 3 min to 24 h post-training, but had no effect when administered 3 days following acquisition. gamma-LGLA administered just after the training session did not affect retention performance during the first 3 h, but suppressed the retention improvement observed in control animals from 6 to 24 h after acquisition; this deficit was still evident 7 days after the treatment. gamma-LGLA partially inhibited L-[3H]glutamate binding on crude hippocampal or striatal membrane preparations; this inhibition was not observed on cerebellar membrane preparations. These results suggest a specific action of gamma-LGLA on excitatory amino acid systems which may be responsible for its effects on learning retention.
journal_name
Brain Resjournal_title
Brain researchauthors
Ungerer A,Schmitz-Bourgeois M,Mélan C,Boulanger Y,Reinbolt J,Amiri I,de Barry Jdoi
10.1016/0006-8993(88)90878-5subject
Has Abstractpub_date
1988-04-19 00:00:00pages
205-11issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90878-5journal_volume
446pub_type
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