Abstract：
:We used double staining immunocytochemical techniques to determine whether nitric oxide (NO) and Fos immunoreactivity induced by noxious visceral stimulation were colocalized in the neurons of the supraspinal areas. We observed a considerable increase in Fos-positive neurons in many brain areas after noxious stimulation but only 15% of the Fos-positive neurons colocalized Nicotinamide Adenine Dinucleotide Phosphate Diaphorase (NADPH-d). The NADPH-d positive cells showed perikarya and cytoplasmic processes laying next to or more frequently apposed to Fos-positive neurons. This anatomical finding supported the hypothesis that also at supraspinal level NO is released near the neurons specifically activated and diffuses through the source cells to act on adjacent neurons playing a role in the central processing of pain transmission and modulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Rodella L,Rezzani R,Agostini C,Bianchi Rdoi
10.1016/s0006-8993(99)01434-1subject
Has Abstractpub_date
1999-07-10 00:00:00pages
173-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01434-1journal_volume
834pub_type
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