Abstract：
:The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) twice daily for 4 days dose-dependently attenuated the development of tolerance to the analgesic and hypothermic effects of U-50,488H (25 mg/kg, i.p.). L-NMMA by itself did not modify the analgesic and hypothermic effects of acute administration of U-50,488H. A potential role for NO in the development of kappa-opiate tolerance is suggested.
journal_name
Brain Resjournal_title
Brain researchauthors
Thorat SN,Reddy PL,Bhargava HNdoi
10.1016/0006-8993(93)90316-fsubject
Has Abstractpub_date
1993-09-03 00:00:00pages
171-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(93)90316-Fjournal_volume
621pub_type
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