Abstract：
:By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS). Further immunoblot analyses showed that the levels of CA II are increased not only in the brain of adult Ts65Dn mice but also in the brain of infants and young children with DS. Cellular localization of the enzyme in human brain, predominantly in the oligodendroglia and primitive vessels in fetal brain and in the oligodendroglia and some GABAergic neurons postnatally, was similar in DS subjects and controls. Given the role of CA II in regulation of electrolyte and water balance and pH homeostasis, up-regulation of CA II may reflect a compensatory mechanism mobilized in response to structural/functional abnormalities in the developing DS brain. However, this up-regulation may also have an unfavorable effect by increasing susceptibility to seizures of children with DS.
journal_name
Brain Resjournal_title
Brain researchauthors
Palminiello S,Kida E,Kaur K,Walus M,Wisniewski KE,Wierzba-Bobrowicz T,Rabe A,Albertini G,Golabek AAdoi
10.1016/j.brainres.2007.11.023subject
Has Abstractpub_date
2008-01-23 00:00:00pages
193-205eissn
0006-8993issn
1872-6240pii
S0006-8993(07)02740-0journal_volume
1190pub_type
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