Abstract：
:The effects of two drugs with anxiolytic actions, diazepam (0.1, 0.3 and 1 mg/kg) and nicotine (0.1 and 0.5 mg/kg) were examined on the time spent in social interaction by pairs of male gerbils. In a test arena lit by high light, diazepam (0.1 mg/kg) increased social interaction, without changing locomotor activity. Diazepam (0.3 and 1 mg/kg) produced a dose-related increase in locomotor activity, which reached significance at the higher dose. Nicotine produced a dose-related increase in social interaction, which reached significance at 0.5 mg/kg, but was without effect on locomotor activity. The specific increases in social interaction observed with diazepam and nicotine are similar to those seen in the well-validated social interaction test of anxiety in rats and suggest that social interaction in gerbils may also be used to screen for anxiolytic action of novel compounds.
journal_name
Brain Resjournal_title
Brain researchauthors
File SE,Cheeta S,Akanezi Cdoi
10.1016/s0006-8993(00)03102-4subject
Has Abstractpub_date
2001-01-12 00:00:00pages
311-313issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03102-4journal_volume
888pub_type
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