Abstract：
:In pentobarbitone-anesthetized cats breathing spontaneously, we studied whether excision of one petrosal ganglion would modify the reflex efficacy of the remaining carotid and aortic chemoafferences in ventilatory control. Resting ventilation was not affected shortly after the ganglionectomy, but decreased sensitivities and reactivities for changes in tidal volume and respiratory frequency were revealed by dose-response curves for ventilatory chemoreflexes evoked by NaCN i.v. After 2 weeks of ganglionectomy, basal tidal volume was increased, being slightly reduced by contralateral carotid neurotomy, but persisting above control after section of all buffer nerves. The ventilatory chemosensory drive--tested by breathing 100% O2--was unmodified with respect to the acute condition, but the tonic ventilatory influence exerted by the right carotid nerve was diminished. Dose-response curves for reflex changes in tidal volume exhibited increased sensitivity, while those for changes in respiratory frequency showed increased reactivity. Thus, partial chemosensory denervation of the nucleus tractus solitarius triggers a slowly developing increase in the reflex efficacy of the remaining chemosensory inputs. The recovery of sensitivity for reflex changes in tidal volume required the presence of contralateral carotid afferents, while the increased reactivity in respiratory frequency needed the integrity of aortic afferents. The results also suggest an enhanced contribution of central structures other than chemosensory inputs in respiratory control after partial deafferentation.
journal_name
Brain Resjournal_title
Brain researchauthors
Eugenin J,Larrain C,Zapata Pdoi
10.1016/0006-8993(90)91495-3subject
Has Abstractpub_date
1990-07-23 00:00:00pages
263-72issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91495-3journal_volume
523pub_type
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