Abstract：
:The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h after the gabaculine treatment. In contrast, no such alteration was detected in kindled animals after a 48-h survival period either with or without the pharmacological manipulation. The present results suggest that kindling causes retardation of GABA-T resynthesis in neurons, since the GABA-T activities detected 16 h after the drug treatment are due to newly synthetized enzyme in presumptive GABA neurons but not glial cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Itagaki S,Kimura Hdoi
10.1016/0006-8993(86)90692-xsubject
Has Abstractpub_date
1986-08-27 00:00:00pages
77-84issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)90692-Xjournal_volume
381pub_type
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