Abstract:
:Rats anticipate a scheduled daily meal by entrainment of a circadian pacemaker separate from the light-entrainable circadian pacemaker located in the suprachiasmatic nuclei (SCN). The site and molecular mechanisms of the food-entrainable pacemaker are unknown. The intrinsic period (tau) of the SCN pacemaker is significantly lengthened by deuteriation. Sensitivity of food-entrained circadian rhythms to D(2)O (25% in drinking water) was evaluated in intact and SCN-ablated rats entrained to daily feeding schedules. In intact rats fed ad-libitum, D(2)O lengthened tau sufficiently to drive activity rhythms out of entrainment to the light-dark cycle. By contrast, food-entrained rhythms were surprisingly resistant to modulation by D(2)O. The mean daily onset time of food anticipatory activity in rats with complete SCN-ablations was not affected by up to 28 days of D(2)O intake. Transient delays and disruption of anticipatory activity were evident in intact and one partial SCN-ablated rat during D(2)O treatment, but these are interpretable as effects of coupling and/or masking interactions between a D(2)O-sensitive light-entrainable pacemaker, and a D(2)O-resistant food-entrained pacemaker. Differential sensitivity to D(2)O suggests diversity in the molecular mechanisms of food- and light-entrainable circadian pacemakers in mammals. D(2)O may have utility as a screening test to identify putative food-entrainable pacemakers from among those central and peripheral tissues that can express circadian oscillations of clock genes independent of the SCN.
journal_name
Brain Resjournal_title
Brain researchauthors
Mistlberger RE,Marchant EG,Kippin TEdoi
10.1016/s0006-8993(01)03042-6subject
Has Abstractpub_date
2001-11-23 00:00:00pages
283-91issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)03042-6journal_volume
919pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90869-0
更新日期:1980-08-11 00:00:00
abstract::Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90315-9
更新日期:1984-12-10 00:00:00
abstract::Myelin of several Caudata (Urodela) species appears to be unique in the fact that it lacks hydroxycerebrosides and hydroxysulfatides although it contains their non-hydroxy counterparts. Comparison of the nerve conduction velocities in the Urodeles Necturus (salamander) and Notophthalmus (newt) with that in a reptile, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90831-5
更新日期:1985-10-14 00:00:00
abstract::The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.045
更新日期:2007-04-20 00:00:00
abstract::The peptide NK1-receptor antagonists, sendide and [D-Trp7]sendide, have been evaluated for antinociceptive activity in the capsaicin test. Both peptides, injected intrathecally (i.t.) 5 min prior to intraplantar capsaicin, produced a dose-dependent reduction of the capsaicin-induced paw licking response. Naloxone (4.0...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91080-4
更新日期:1994-06-27 00:00:00
abstract::Central activation of excitatory amino acid receptors has been implicated in neuropathic pain following nerve injury. In a rat model of painful peripheral mononeuropathy, we compared the effects of non-competitive NMDA receptor antagonists (MK 801 and HA966) and a non-NMDA receptor antagonist (CNQX) on induction and m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90193-d
更新日期:1992-12-11 00:00:00
abstract::The conduction velocity of frog ischiadic nerves incubated in vitro in osmolarities between 220 and 1000 mOsm decreased with the degree of fiber shrinkage. The latter (non-circularity factor) was determined from computer-assisted measurements in freeze-substituted or in chemically fixed fibers. Freeze-substituted norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90546-8
更新日期:1984-04-09 00:00:00
abstract::Recordings have been made from 162 pyramidal tract neurones which discharged bursts of nerve impulses in characteristic temporal association with performances of a stereotyped motor task by monkeys. Clinical evaluation of the relationship between discharges of the neurones and free movement led to the view that each c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90507-7
更新日期:1975-11-07 00:00:00
abstract::Previous studies have demonstrated a higher mean peak frequency of the hippocampal (HPC) theta rhythm during REM sleep in alcohol-nonpreferring (NP) rats when compared with alcohol-preferring (P) rats. Burst firing neurons of the medial septal area (MS/VDB) are thought to pace the HPC theta rhythm during REM sleep and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01520-5
更新日期:1996-04-01 00:00:00
abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90901-0
更新日期:1983-10-24 00:00:00
abstract::Experiments were performed in ambulating decerebrate ferrets to examine the activity of up to 6 simultaneously recorded Purkinje cells oriented sagittally during unperturbed and perturbed locomotion using a new analytical technique, the real-time postsynaptic response (RTPR), which permits a trial-by-trial assessment ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91646-x
更新日期:1986-02-19 00:00:00
abstract::In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90771-8
更新日期:1988-06-07 00:00:00
abstract::Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02542-8
更新日期:2002-05-17 00:00:00
abstract::The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91256-0
更新日期:1989-01-09 00:00:00
abstract::We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E2. Indwelling cannulas in the third ventricle of lambs (age, 5-31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for radioimmunoassay of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00946-n
更新日期:1995-11-27 00:00:00
abstract::Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90746-5
更新日期:1980-10-06 00:00:00
abstract::Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01488-8
更新日期:1996-03-25 00:00:00
abstract::A quantitative double blind procedure is described to test the myelinotoxicity of cerebrospinal fluid (SSF) by using optic nerves of Xenopus tadpoles as an in vivo model of a myelinated CNS tract. Only 0.5 ml of unconcentrated CSF is needed for a test and the result is known in 5 days. Groups of 8-10 Xenopus tadpoles ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90500-5
更新日期:1977-01-14 00:00:00
abstract::The development of the dorsal root potential (DRP) and the responsiveness of primary afferent fibers to gamma-aminobutyric acid (GABA) were investigated in the isolated spinal cord of rat fetuses. At embryonic day 15.5, stimulation of the lumbar dorsal root was first effective in eliciting the DRP, which was not inhib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90127-0
更新日期:1985-01-01 00:00:00
abstract::Cytochrome P45011B1 (11 beta-hydroxylase) was detected in the brain of male rats by in situ hybridization methods. Normal Sprague-Dawley rats were compared to the transgenic strain TGR(mRen2)27, characterized by the expression of the murine Ren-2d renin gene and the development of severe hypertension. Specific ribopro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00540-9
更新日期:1996-09-09 00:00:00
abstract::We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.062
更新日期:2004-08-13 00:00:00
abstract::The possible involvement of catecholamines in the regulation of serotonin N-acetyltransferase (NAT) activity in retina of the African clawed frog was investigated using an in vitro eye cup preparation. Dopamine (10 microM) and norepinephrine (50 microM) had no significant effect on NAT activity of eye cups incubated i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90525-1
更新日期:1986-03-26 00:00:00
abstract::Choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities were measured in various visual structures of the pigeon brain after long-term monocular deprivation followed by short-term binocular presence or absence of light stimulation. The short-term phase (45 min) was coupled with a 2-deoxygluco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91253-7
更新日期:1982-09-16 00:00:00
abstract::Previous studies have demonstrated that postnatal (days 2-29 of life) administration of lead (200 mg/kg/day by gavage) to Long-Evans rats caused permanent increases in lithium-induced polydipsia (LIP). These lead-induced increases in LIP were apparently not of renal origin, did not occur in animals treated with lead a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90570-5
更新日期:1984-04-16 00:00:00
abstract::We examined the role of the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclic AMP-response element binding protein (CREB) in N-methyl-d-aspartate (NMDA)-induced neurotoxicity in the rat retina. Western blot analysis showed early elevation of phosphorylated CaMKII (p-CaMKII) protein ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.055
更新日期:2007-12-12 00:00:00
abstract::The central melanocortin system plays a critical role in regulation of energy balance, including thermogenesis in brown adipose tissue (BAT). Activation of the hypothalamic melanocortin signaling stimulates sympathetically-mediated interscapular BAT (IBAT) thermogenesis. The rostral raphe pallidus (rRPa) and adjacent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.006
更新日期:2007-11-07 00:00:00
abstract::The GABA agonist muscimol, injected into the depressor area of the caudal ventrolateral medulla, increased blood pressure and increased the expression of the immediate early gene c-fos in the rostral ventral medulla (RVM) of the rat. The number of Fos-immunoreactive (Fos-IR) neurons seen in the RVM was increased 3-fol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90056-6
更新日期:1994-05-16 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90442-4
更新日期:1980-09-15 00:00:00
abstract::The effects of lateral hypothalamic (LH) lesions were studied in golden-mantled ground squirrels, Spermophilus lateralis, a species of mammalian hibernator that displays endogenous circannual body weight cycles when kept in constant conditions. The lesions were made during the weight-gain phase. Evidence that the lesi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91518-0
更新日期:1986-12-10 00:00:00
abstract::1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90934-7
更新日期:1989-05-15 00:00:00