Abstract：
:A quantitative double blind procedure is described to test the myelinotoxicity of cerebrospinal fluid (SSF) by using optic nerves of Xenopus tadpoles as an in vivo model of a myelinated CNS tract. Only 0.5 ml of unconcentrated CSF is needed for a test and the result is known in 5 days. Groups of 8-10 Xenopus tadpoles received a subcutaneous injection of 12-13 muL of a coded CSF sample or of a saline control solution around the right optic nerve. After 48 h, whole mounts of the right optic nerves were prepared and the slides were randomized before using a differential-interference contrast microscope to count the myelin lesions. The myelinotoxicity of a CSF sample was considered positive (+) when it produced significantly higher (P less than 0.01) counts than the saline control. When P was less than 0.05, the counts were recorded as borderline (+/-) and it was negative (-) when P was greater than 0.05.
journal_name
Brain Resjournal_title
Brain researchauthors
Tabira T,Webster HD,Wray SHdoi
10.1016/0006-8993(77)90500-5subject
Has Abstractpub_date
1977-01-14 00:00:00pages
103-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(77)90500-5journal_volume
120pub_type
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