Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis.

Abstract:

:Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.

journal_name

Brain Res

journal_title

Brain research

authors

Rock JP,Oldfield EH,Schulte HM,Gold PW,Kornblith PL,Loriaux L,Chrousos GP

doi

10.1016/0006-8993(84)90315-9

subject

Has Abstract

pub_date

1984-12-10 00:00:00

pages

365-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)90315-9

journal_volume

323

pub_type

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