Abstract:
:Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.
journal_name
Brain Resjournal_title
Brain researchauthors
Rock JP,Oldfield EH,Schulte HM,Gold PW,Kornblith PL,Loriaux L,Chrousos GPdoi
10.1016/0006-8993(84)90315-9subject
Has Abstractpub_date
1984-12-10 00:00:00pages
365-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90315-9journal_volume
323pub_type
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