Estradiol benzoate decreases nigral GABAergic activity in male rats.

abstract：:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...

journal_title：Brain research

authors： Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

更新日期：1999-10-16 00:00:00

abstract：:Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...

journal_title：Brain research

authors： Reuveny E,Narahashi T

更新日期：1993-02-12 00:00:00

abstract：:The neurotoxic effects of amyloid-beta(1-42) and amyloid-beta(25-35) (A beta) on cholinergic and acetylcholinesterase-positive neurons were investigated in primary cultures derived from embryonic 18-day-old rat basal forebrain. After various time intervals, the cultures were treated with 1, 5, 10 or 20 microM A beta f...

journal_title：Brain research

authors： Kasa P Sr,Papp H,Kasa P Jr,Pakaski M,Balaspiri L

更新日期：2004-02-13 00:00:00

abstract：:A hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal cord has been well documented and recently related to states of pain and analgesia. In order to study the action of the neuropeptide oxytocin (OT) on pain-related responses, we compared dorsal horn neuronal responses to electric...

journal_title：Brain research

authors： Condés-Lara M,Maie IA,Dickenson AH

更新日期：2005-05-31 00:00:00

abstract：:Previous parkinsonian rat models have utilized stereotactic 6-OHDA injections to completely lesion the dopaminergic mesostriatal system on one side. Recently, hemiparkinsonian rat models in which the mesolimbic system is left intact have been developed. The selective, partial lesion models better mimic the neuropathol...

journal_title：Brain research

authors： Sakai K,Gash DM

更新日期：1994-01-07 00:00:00

abstract：:The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in cultu...

journal_title：Brain research

authors： Manev H,Favaron M,Candeo P,Fadda E,Lipartiti M,Milani D

更新日期：1993-10-08 00:00:00

abstract：:Recently developed antisera selective for angiotensin Type 2 (AT2) receptors were used to localize AT2 receptors in rat brain by immunohistochemistry. While the results from these experiments were largely consistent with previous autoradiographic and radioligand binding analyses of AT2 receptor populations in brain, t...

journal_title：Brain research

authors： Reagan LP,Flanagan-Cato LM,Yee DK,Ma LY,Sakai RR,Fluharty SJ

更新日期：1994-10-31 00:00:00

abstract：:Our recent researches have identified increased expression of miR-21-5p in rats brain following traumatic brain injury (TBI), which protected against blood-brain barrier (BBB) damage. To further study the mechanism underlying the role of miR-21-5p on alleviating BBB damage after TBI, we performed the scratch injury mo...

journal_title：Brain research

authors： Ge X,Huang S,Gao H,Han Z,Chen F,Zhang S,Wang Z,Kang C,Jiang R,Yue S,Lei P,Zhang J

更新日期：2016-11-01 00:00:00

abstract：:We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal ...

journal_title：Brain research

authors： Boraud T,Bezard E,Guehl D,Bioulac B,Gross C

更新日期：1998-03-16 00:00:00

abstract：:The present study reveals developmental changes in the number, the phenotype and the distribution pattern of mast cells (MCs) along the cervical, the thoracic and the lumbar parts of the spinal dura mater. Postnatal infiltration of spinal dura by MCs does not appear to follow a sequential developmental pattern and men...

journal_title：Brain research

authors： Michaloudi H,Batzios C,Chiotelli M,Grivas I,Papadopoulos GC

更新日期：2008-08-21 00:00:00

abstract：:The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathwa...

journal_title：Brain research

authors： Shimizu N,Oomura Y,Novin D,Grijalva CV,Cooper PH

更新日期：1983-04-11 00:00:00

abstract：:The content of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) was analysed in 71 human spinal cords obtained post-mortem. The highest content of 5-HT, 5-HIAA and NE was found in the lumbar enlargement of the spinal cord. 5-HT and 5-HIAA content increased from fetal to adult spinal cord w...

journal_title：Brain research

authors： Lacković Z,Jakupcević M,Bunarević A,Damjanov I,Relja M,Kostović I

更新日期：1988-03-08 00:00:00

abstract：:Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins between cellular membranes, and androgen receptor (AR) mRNA are both increased in song control nuclei of juvenile males comp...

journal_title：Brain research

authors： Wu D,Tang YP,Wade J

更新日期：2010-07-09 00:00:00

abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...

journal_title：Brain research

authors： Zalcman S,Shanks N,Anisman H

更新日期：1991-08-23 00:00:00

abstract：:Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity. Cyclin-dependent kinase 5 (CDK5) and its activator p35 are required for neurite outgrowth. The cleavage of p35 to p25, mediated by calpain and calcium...

journal_title：Brain research

authors： Chen X,Huang T,Zhang J,Song J,Chen L,Zhu Y

更新日期：2008-03-20 00:00:00

abstract：:FRAT1 was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, which inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. FRAT1 has been identified as a proto-oncogene involved in tumorigenesis. Previous studies have shown that ...

journal_title：Brain research

authors： Guo G,Mao X,Wang P,Liu B,Zhang X,Jiang X,Zhong C,Huo J,Jin J,Zhuo Y

更新日期：2010-03-12 00:00:00

abstract：:Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...

journal_title：Brain research

authors： Siegfried B,Hefti F,Lichtensteiger W,Huston JP

更新日期：1979-01-12 00:00:00

abstract：:Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...

journal_title：Brain research

authors： Hori N,Ffrench-Mullen JM,Carpenter DO

更新日期：1985-12-09 00:00:00

abstract：:The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...

journal_title：Brain research

authors： Kruger L,Mantyh PW,Sternini C,Brecha NC,Mantyh CR

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...

journal_title：Brain research

authors： Zhang J,Fu B,Zhang X,Chen L,Zhang L,Zhao X,Bai X,Zhu C,Cui L,Wang L

更新日期：2013-08-28 00:00:00

abstract：:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...

journal_title：Brain research

authors： Ault B,Caviedes P,Rapoport SI

更新日期：1989-04-17 00:00:00

abstract：:Retinoic acid (RA), which is an important modulator of brain development, neural cell proliferation, neurite outgrowth, and synaptic plasticity, is regulated via changes in RA receptors. The pattern of RA receptor changes in the rat cerebral cortex and white matter during postnatal development has not been extensively...

journal_title：Brain research

authors： Jiang W,Wen EY,Gong M,Shi Y,Chen L,Bi Y,Zhang Y,Liu YF,Chen J,Qu P,Liu YX,Wei XP,Li TY

更新日期：2011-03-25 00:00:00

abstract：:Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administer...

journal_title：Brain research

authors： Gandolfo G,Gottesmann C,Bidard JN,Lazdunski M

更新日期：1989-08-21 00:00:00

abstract：:A procedure is described which allows for the selective and non-injectional staining of the three-dimensional microvasculatory bed (MVB) in thick sections (60-140 microm) of formalin-fixed brain tissue of white rats Rattus norvegicus. This histochemical method detects ATPase activity and takes place between pH 10.5 an...

journal_title：Brain research

authors： Chilingaryan A,Chilingaryan AM,Martin GG

更新日期：2006-01-27 00:00:00

abstract：:At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at...

journal_title：Brain research

authors： Liu X,Chung K,Chung JM

更新日期：1999-12-04 00:00:00

abstract：:Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...

journal_title：Brain research

authors： Itier RJ,Alain C,Kovacevic N,McIntosh AR

更新日期：2007-10-26 00:00:00

abstract：:To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...

journal_title：Brain research

authors： Gherri E,Berreby F

更新日期：2017-10-15 00:00:00

abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...

journal_title：Brain research

authors： Kubo KY,Iwaku F,Watanabe K,Fujita M,Onozuka M

更新日期：2005-09-28 00:00:00

abstract：:Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...

journal_title：Brain research

authors： Segal DS

更新日期：1976-11-05 00:00:00

abstract：:A potential mechanism for valproate (VPA)-induced increases in glial cell-substratum adhesivity has been demonstrated. Metabolically labelled glioma (C6) and primary astrocytes showed a statistically significant accumulation of protein when cultured in the presence of therapeutic concentrations of VPA (1 mM). This was...

journal_title：Brain research

authors： Martin ML,Regan CM

更新日期：1988-08-30 00:00:00