Abstract：
:An immunoneutralization technique with specific antibodies was used to explore the role of endogenous neuropeptide Y (NPY) in the adrenocorticotropic hormone (ACTH) release after hypoglycemic stress in the dog. Dogs received injections of rabbit antihuman NPY gamma-globulin (anti-NPY) or normal gamma-globulin (NGG) into the third cerebral ventricle, which was followed by i.v. injection of insulin. Hypoglycemia of a 40% fall in systemic glucose levels occurred in anti-NPY-treated dogs as well as NGG-treated animals. An intraventricular administration of anti-NPY significantly inhibited the ACTH and cortisol release to hypoglycemia, but had no effect on the pancreatic polypeptide (PP) response. These findings suggest involvement by endogenous NPY in the ACTH secretion induced by hypoglycemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Inui A,Inoue T,Nakajima M,Okita M,Sakatani N,Okimura Y,Chihara K,Baba Sdoi
10.1016/0006-8993(90)91369-rsubject
Has Abstractpub_date
1990-03-05 00:00:00pages
211-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91369-Rjournal_volume
510pub_type
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