Abstract:
:In a previous study the collateralization of the rubrospinal tract in the spinal cord of rat, cat and monkey was studied by means of the fluorescent retrograde double labeling technique. In the present study the existence of rubrospinal collaterals to the cerebellar interpositus nucleus (NI) has been studied using the same technique. In rat 'True Blue' (TB) was injected in the cerebellar NI and 'Nuclear Yellow' (NY) was injected ipsilaterally in white and gray matter of C5-C8 spinal segments. In some cases a new fluorescent retrograde tracer was used instead of NY, i.e. 'Diamidino Yellow' (DY), which produces retrograde labeling similar to NY but which migrates only very slowly out of the retrogradely labeled neurons. In these experiments only very few single TB-labeled rubrocerebellar neurons occurred, but many (+/- 90%) of the TB-fluorescent rubrocerebellar neurons were TB-NY or TB-DY double-labeled from the spinal cord. At least 37% of the NY and DY-fluorescent rubrospinal neurons were NY-TB and DY-TB double-labeled from the cerebellum. These findings indicate that, in rat, almost all rubrocerebellar fibers represent collaterals of rubrospinal neurons, and that at least 37% of the rubrospinal neurons give rise to such cerebellar collaterals.
journal_name
Brain Resjournal_title
Brain researchauthors
Huisman AM,Kuypers HG,Condé F,Keizer Kdoi
10.1016/0006-8993(83)90816-8subject
Has Abstractpub_date
1983-04-04 00:00:00pages
181-96issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90816-8journal_volume
264pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.023
更新日期:2006-10-30 00:00:00
abstract::The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. CSF production was measured by the ventriculo-cisternal perfusion method with Blue dextran 2000 used as an indicat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91027-c
更新日期:1992-10-23 00:00:00
abstract::Spontaneous and hypothalamically induced hippocampal rhythmical slow activity (RSA or theta) was studied acutely in rats anaesthetized with urethane or immobilized with D-tubocurarine. Systematic tracking of microelectrodes showed two foci of hippocampal RSA, one located in the basal part (stratum oriens) of CAl (mean...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90711-3
更新日期:1976-12-17 00:00:00
abstract::Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00617-9
更新日期:1998-08-17 00:00:00
abstract::We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90087-8
更新日期:1986-09-01 00:00:00
abstract::DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90144-x
更新日期:1992-06-12 00:00:00
abstract::Brief applications of high glycine concentrations to hippocampal slices have been shown to produce long-lasting changes in synaptic efficacy. In the present study, we show that glycine application transiently and reversibly increases the amplitude and prolongs the duration of synaptic potentials mediated by N-methyl-D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90329-l
更新日期:1993-11-12 00:00:00
abstract::In a previous study we reported significant elevations of TRH in neocortex, hippocampus and combined amygdala/pyriform cortex in rats 48 h after the last of a series of stage 5 kindled seizures. In the present study, to determine whether the increases in TRH were proportional to the intensity of the convulsions, and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91330-j
更新日期:1990-08-13 00:00:00
abstract::The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91155-2
更新日期:1985-09-16 00:00:00
abstract::The solitary tract nucleus (NTS) is the termination site for cranial visceral afferents-peripheral primary afferent neurons which differ by phenotype (e.g. myelinated and unmyelinated). These afferents have very uniform glutamate release properties calculated by variance mean analysis. In the present study, we optical...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.042
更新日期:2010-02-02 00:00:00
abstract::Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.11.027
更新日期:2016-01-15 00:00:00
abstract::Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02050-8
更新日期:1999-11-20 00:00:00
abstract::Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00362-4
更新日期:1997-06-06 00:00:00
abstract::There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.005
更新日期:2004-10-01 00:00:00
abstract::Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91312-3
更新日期:1992-10-16 00:00:00
abstract::High cell density, with attendant aggregation, selectively increases expression of substance P (SP) and choline acetyltransferase (ChAT) in virtually pure neonatal sympathetic neuronal cultures. To investigate the specific role of cell contact in selective transmitter expression, SP content and ChAT activity were exam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80202-5
更新日期:1986-12-01 00:00:00
abstract::Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.087
更新日期:2008-11-25 00:00:00
abstract::Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2012.04.031
更新日期:2012-06-26 00:00:00
abstract::Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91327-6
更新日期:1983-04-11 00:00:00
abstract::To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00194-2
更新日期:1998-05-04 00:00:00
abstract::Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90371-h
更新日期:1990-12-24 00:00:00
abstract::We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01472-9
更新日期:1999-06-12 00:00:00
abstract::Morphological changes in neocortical somatostatin- and neuropeptide-Y-immunoreactive cells in senile dementia of the Alzheimer type (SDAT) were studied using light-microscopic immunohistochemical methods. The density of somatostatin-immunoreactive cells in the neocortex did not decrease in cases of SDAT compared with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91099-1
更新日期:1986-04-02 00:00:00
abstract::Event-related potentials (ERPs) were recorded using a large electrode array while subjects engaged in tasks designed to dissociate control from storage/maintenance processes in verbal working memory (WM). Increased ERP negativity (450-900 ms post-stimulus onset) over left frontal regions emerged only when required dyn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.083
更新日期:2007-10-03 00:00:00
abstract::This study has presented cells, fibers and non-neuronal elements as seen in 3 dimensions using the SEM. Our discussion on possible artifacts which can occur with this method is offered in the hope that others will develop better techniques of dissection and specimen preparation. With the picture of normal tissue in mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-0173(84)90006-7
更新日期:1984-12-01 00:00:00
abstract::The olfactory bulb electroencephalogram (EEG) has been used as a method to imply receptor events12,13. However, experiments to correlate olfactory receptor and bulbar EEG activity in the same species of fish has not been performed. Reported here is the comparison between the simultaneously recorded receptor electroolf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90170-6
更新日期:1982-10-07 00:00:00
abstract::Recent research suggests that in addition to its prominent role in appetitive learning, the nucleus accumbens (NAC) may also be involved in fear conditioning. In the present study, we investigated whether temporary inactivation of the NAC, by injection of tetrodotoxin (TTX), affects acquisition and expression of condi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.037
更新日期:2004-11-19 00:00:00
abstract::Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.014
更新日期:2011-05-10 00:00:00
abstract::We have conducted studies in intact adult male rats, designed to examine the effect of a 3- or 7-day exposure to alcohol (EtOH) on the pituitary's response to corticotropin-releasing hormone (CRF) or stress, and on CRF expression in the hypothalamus. In a first series of experiments, rats exposed to EtOH vapors for 7 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91685-a
更新日期:1990-06-18 00:00:00
abstract::We determined whether pentobarbital anesthetic is required to culture postmortem adult rat neurons. Pentobarbital treatment resulted in two-fold increases in neuron survival in culture after 2 and 4 h postmortem compared to non-anesthetic controls, but was not as effective as simple postmortem treatment on ice and the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.006
更新日期:2004-05-29 00:00:00