Abstract：
:Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P analogues (i.e., GR73638 and [Sar9,Met(O2)11]-substance P) which were selective NK-1 receptor agonists, had no impact on the cardioacceleration evoked by microinjection of L-glutamate (P > 0.05). In addition, microinjection of these analogues had no effect on the modest and non-significant increase in phrenic nerve discharge evoked by L-glutamate. We conclude that stimulation of NK-1 receptors in the superficial laminae of the dorsal horn potentiates the pressor responses to microinjection of L-glutamate.
journal_name
Brain Resjournal_title
Brain researchauthors
Beyaert CA,Hill JM,Kaufman MPdoi
10.1016/s0006-8993(97)00362-4subject
Has Abstractpub_date
1997-06-06 00:00:00pages
175-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00362-4journal_volume
759pub_type
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