Abstract：
:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip strength (P<0.05, met-free BDNF; P<0.01, met-BDNF) and running speed (P<0.01 for both groups) improved compared to vehicle. At 5 mg/kg, the beneficial effect was more modest. Plasma BDNF levels after the final injection were dose-dependent and did not differ between BDNF groups. Endogenous met-free BDNF exerts effects similar to met-BDNF in wobbler MND.
journal_name
Brain Resjournal_title
Brain researchauthors
Ishiyama T,Ogo H,Wong V,Klinkosz B,Noguchi H,Nakayama C,Mitsumoto Hdoi
10.1016/s0006-8993(02)02881-0subject
Has Abstractpub_date
2002-07-19 00:00:00pages
195-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302028810journal_volume
944pub_type
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