Abstract：
:In the first postnatal month, the thickness of the cerebral cortex has different patterns of development in the male and female Long-Evans rat. All areas of the male cortex appear to develop at similar rates, very rapidly for the first 10 days, then more gradually reaching a peak somewhere between 30 and 40 days of age before beginning to decrease in thickness. The same is not true for the female; for example, at birth her medial frontal cortex is further developed than her lateral posterior parietal cortex and the rate of growth in the first weeks varies immensely. The male right cortex is thicker than the left from birth to 904 days of age, but the differences become less significant with age. The female cortex is thicker on the left side in the majority of the cases, from 7 to 400 days of age, but the differences are not in general statistically significant. Estrogen receptors are found in both male and female rat cerebral cortices at birth and apparently disappear after one month. In the male the greatest concentration of receptors is in the left cortex, and in the female, in the right. The number of neurons and glia per unit area is greater in the right cortex (area 39) in the male; and in the female, in the left cortex. Ninety days after ovariectomy at birth, the female right cortex is thicker than her left, establishing a pattern similar to that of the male. In the male gonadectomized at birth, the left cortex is thicker 90 days later in the frontal and somatosensory regions but not in the occipital or posterior region.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Diamond MCdoi
10.1016/0165-0173(87)90014-2subject
Has Abstractpub_date
1987-05-01 00:00:00pages
235-40issue
2eissn
0006-8993issn
1872-6240journal_volume
434pub_type
杂志文章,评审相关文献
BRAIN RESEARCH文献大全abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:The organization of neuronal cell bodies in the caudal preoptic area (POA) and rostral anterior hypothalamic area (AH) was studied in Nissl-stained brain sections from adult male and female ferrets. Computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90837-1
更新日期：1986-02-05 00:00:00
abstract：:In the schedule-induced polydipsia model, hungry rats receiving a food pellet every minute will display excessive drinking behaviour (compulsive behaviour). We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.043
更新日期：2008-03-27 00:00:00
abstract：:The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90077-3
更新日期：1982-01-01 00:00:00
abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90021-0
更新日期：1987-04-01 00:00:00
abstract：:The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90773-0
更新日期：1986-08-06 00:00:00
abstract：:The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced membrane depolarization of mouse spinal cord neurons in primary dissociated cell culture by blocking a potassium conductance, a non-synaptic dir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90609-6
更新日期：1982-01-28 00:00:00
abstract：:Previous studies have suggested that monosynaptic transmission between spinal primary afferent fibers and motoneurons is mediated by an excitatory amino acid, most likely glutamate or aspartate. No such comparable studies have been carried out in the trigeminal system. In an attempt to elucidate the neurotransmitter(s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91413-3
更新日期：1989-01-16 00:00:00
abstract：:There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(85)90010-4
更新日期：1985-06-01 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.027
更新日期：2016-10-15 00:00:00
abstract：:The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.024
更新日期：2004-02-20 00:00:00
abstract：:In a focused attention task saccadic reaction time (SRT) to a visual target stimulus (LED) was measured with an auditory (white noise burst) or tactile (vibration applied to palm) nontarget presented in ipsi- or contralateral position to the target. Crossmodal facilitation of SRT was observed under all configurations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.081
更新日期：2008-11-25 00:00:00
abstract：:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.070
更新日期：2009-09-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:Aggression is a major source of social stress with negative effects on health and well-being, yet limited information is known about the molecular mechanisms mediating aggressive behavior in swine. Ractopamine (RAC) is a β-adrenoreceptor agonist that enhances growth but increases aggressive behaviors in female pigs. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.035
更新日期：2011-03-24 00:00:00
abstract：:Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01008-0
更新日期：1995-12-01 00:00:00
abstract：:The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02877-9
更新日期：2002-07-26 00:00:00
abstract：:The current study investigated the time course of the implicit processing of erotic stimuli using event-related potentials (ERPs). ERPs elicited by erotic pictures were compared with those by three other types of pictures: non-erotic positive, negative, and neutral pictures. We observed that erotic pictures evoked enh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.019
更新日期：2012-12-13 00:00:00
abstract：:This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01700-x
更新日期：1999-08-07 00:00:00
abstract：:Previous studies have shown that preganglionic nerve stimulation in vitro increases acutely the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, in sympathetic neuronal cell bodies in the rat superior cervical ganglion (SCG). In the present study, we have examined whether ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90506-7
更新日期：1990-07-30 00:00:00
abstract：:Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01210-9
更新日期：1998-01-19 00:00:00
abstract：:The functional regulation by dopamine (DA) receptors of serotonin (5-HT) release from the rat substantia nigra (SN) was investigated using in vivo microdialysis. A D1- and D2-receptor-mediated inhibition of nigral 5-HT release was demonstrated in this study. Continuous administration of the D1-receptor agonist CY 2082...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00336-9
更新日期：1998-06-15 00:00:00
abstract：:Single unit extracellular recordings were obtained from cat lumbar spinal cord dorsal horn neurons activated by cutaneous inputs. The effect of electrical conditioning stimuli applied to the red nucleus (RN) was predominantly that of inhibition although in some cases excitation was seen. All the neurons that projected...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91413-6
更新日期：1984-10-08 00:00:00
abstract：:Mouse brain expresses three principal glucose transporters. Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells. A mouse line with a null allele for Glut3 has been developed. The Glut3(-/-) genotype is intraut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.014
更新日期：2011-04-12 00:00:00
abstract：:Mitochondria critically regulate cytoplasmic Ca(2+) concentration ([Ca(2+)]c), but the effects of sensory neuron injury have not been examined. Using FCCP (1µM) to eliminate mitochondrial Ca(2+) uptake combined with oligomycin (10µM) to prevent ATP depletion, we first identified features of depolarization-induced neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.040
更新日期：2014-11-17 00:00:00
abstract：:We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91136-x
更新日期：1987-06-02 00:00:00
abstract：:The present paper examines the hypothesis that the long latency EMG activity produced by muscle stretch is the result of long loop reflex pathways involved in the control of limb stiffness. We recorded the cerebral responses and late EMG activity in agonist and antagonist muscles following sudden stretch of the wrist ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91159-c
更新日期：1992-08-28 00:00:00
abstract：:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90152-2
更新日期：1989-08-07 00:00:00
abstract：:The present study was designed to investigate the distribution of serotonin 5-HT1A receptor protein (5-HT1A-immunoreactivity) and its localization within cortical pyramidal neurons of the rat cingulate cortex. This experimental direction was inspired by recent data showing the role of 5-HT1A receptors in the pathology...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03352-3
更新日期：2003-10-31 00:00:00
