当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Comparative study of the effects of electrical stimulation in the nucleus accumbens, the mediodorsal thalamic nucleus and the bed nucleus of the stria terminalis in rats with schedule-induced polydipsia.

Comparative study of the effects of electrical stimulation in the nucleus accumbens, the mediodorsal thalamic nucleus and the bed nucleus of the stria terminalis in rats with schedule-induced polydipsia.

Abstract：

:In the schedule-induced polydipsia model, hungry rats receiving a food pellet every minute will display excessive drinking behaviour (compulsive behaviour). We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminalis (BST) can decrease water intake in the schedule-induced polydipsia model; 2) to compare water intake between these groups for different stimulation amplitudes; and 3) to compare the effect of low frequency (2 Hz) with high frequency (100 Hz) stimulation. Rats were randomly divided into four groups: electrode implanted in the 1) N ACC (n=7), 2) MD (n=8), 3) BST (n=8), or 4) a sham-operated control group (n=7). Postoperatively, each rat of group 1, 2 and 3 was randomly tested in the model using pulses with a frequency of 2 Hz and 100 Hz, each at an amplitude of 0.1, 0.2, 0.3, 0.4 and 0.5 mA, or without stimulation. Group 4 was tested 11 times without stimulation. Each day the rats were tested in random order. High-frequency electrical stimulation in all three brain areas decreased water intake significantly at an amplitude of 0.2 mA or higher, however, without differences between the brain areas. Based on these results, we expect a decrease in compulsions in patients suffering from treatment-resistant obsessive-compulsive disorder during electrical stimulation in the N ACC, the MD and the BST. However, we foresee no difference in energy consumption to decrease symptoms during electrical stimulation between these brain areas.

journal_name

Brain Res

journal_title

Brain research

authors

van Kuyck K,Brak K,Das J,Rizopoulos D,Nuttin B

doi

10.1016/j.brainres.2008.01.043

subject

Has Abstract

pub_date

2008-03-27 00:00:00

pages

93-9

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(08)00147-9

journal_volume

1201

pub_type

杂志文章

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