Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.

Abstract:

:High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H]aspartate (59% of control, P less than 0.005) and concentrations of L-aspartate (79% of control, P less than 0.05) in the ventral tegmental area suggesting the presence of an aspartatergic projection from medial prefrontal cortex to this area.

journal_name

Brain Res

journal_title

Brain research

authors

Christie MJ,Bridge S,James LB,Beart PM

doi

10.1016/0006-8993(85)90140-4

subject

Has Abstract

pub_date

1985-04-29 00:00:00

pages

169-72

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(85)90140-4

journal_volume

333

pub_type

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