Abstract:
:Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these functions, we investigated the influence of a deficiency of LECT2 on the morphology of cultured hippocampal neurons during neuronal development, and examined the expression of neurotrophins (NGF, BDNF, and NT-3) and their receptors (TrkA, TrkB, TrkC, and p75NTR) in these neurons. The extension of axons and dendrites in neurons from LECT2-knockout (LECT2-KO) mice was shorter than that in neurons from wild-type mice during culture and significantly less than that in wild-type mice after 4 days in culture. Moreover, neurons from LECT2-KO mice showed different expression of NGF, BDNF and NT-3 during culture compared to wild-type mice. Our results show that LECT2 regulates the extension of axons and dendrites and the expressions of NGF, BDNF and NT-3 during neuronal development.
journal_name
Brain Resjournal_title
Brain researchauthors
Koshimizu Y,Ohtomi Mdoi
10.1016/j.brainres.2009.11.010subject
Has Abstractpub_date
2010-01-22 00:00:00pages
1-11eissn
0006-8993issn
1872-6240pii
S0006-8993(09)02402-0journal_volume
1311pub_type
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