Abstract：
:We have previously reported that intracerebroventricular injection of prostaglandin E2 (PGE2) induces hyperthermia possibly through EP1 receptors in the rat. In the present study, to determine the sites in the brain where PGE2 induces hyperthermia through EP1 receptors, we microinjected an EP1 receptor agonist, 17-phenyl-omega-trinor PGE2 (17-Ph-PGE2, 100 ng) into different sites in the rat brain and observed the colonic temperature (Tco) for 2 h in a 23 +/- 1 degrees C environment. Responsive sites where 17-Ph-PGE2 (100 ng) produced a rise in the Tco of more than 1.1 degrees C within 60 min after injection were found in the medial preoptic area, the subchiasmatic portion of the median preoptic nucleus, the anterior wall of the third ventricle (A3V) and the ventral portion of the diagonal band of Broca. Among these sites, the A3V was the most responsive. In contrast, microinjection of neither butaprost (an EP2 agonist, 100 ng) nor M&B28767 (an EP3 agonist, 100 ng) into these four sites had any effect on the Tco. Intracerebroventricular pretreatment with SC-19220 (an EP1 antagonist, 100 microg) inhibited the rise in the Tco which was induced by microinjection of PGE2 (50 ng) into the A3V. These results thus suggest that PGE2 induces hyperthermia by stimulating EP1 receptors in the A3V and the neighboring preoptic region.
journal_name
Brain Resjournal_title
Brain researchauthors
Oka K,Oka T,Hori Tdoi
10.1016/s0006-8993(97)00562-3subject
Has Abstractpub_date
1997-08-29 00:00:00pages
92-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00562-3journal_volume
767pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90963-a
更新日期：1992-05-15 00:00:00
abstract：:The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91775-n
更新日期：1993-05-14 00:00:00
abstract：:Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91498-h
更新日期：1993-04-02 00:00:00
abstract：:The periaqueductal gray was shown to be an important component of morphine analgesia and tolerance. Two-way analgesic cross tolerance was obtained between systemic and intracerebral morphine administrations when the intracerebral site was the periaqueductal gray. Rats were pretreated with intraperitoneal morphine and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90448-0
更新日期：1976-02-27 00:00:00
abstract：:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90164-9
更新日期：1989-08-07 00:00:00
abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.038
更新日期：2005-09-28 00:00:00
abstract：:The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91622-8
更新日期：1991-01-25 00:00:00
abstract：:Morphological alterations occurring in Schwann cells of unmyelinated fibers (unmyelinated Schwann cells) were investigated in the sciatic nerve of the twicher mouse, a murine model of human globoid cell leukodystrophy. After postnatal day 10, the number of Schwann cell-axon units gradually increased and the number of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91719-8
更新日期：1989-11-27 00:00:00
abstract：:Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.039
更新日期：2016-05-15 00:00:00
abstract：:Possible involvement of the amygdaloid input in long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses in vivo was investigated by evaluating the effects of lesions of the amygdaloid nucleus. The dentate gyrus synaptic potential evoked by low-frequency test stimulation did not ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91377-3
更新日期：1994-09-05 00:00:00
abstract：:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02308-9
更新日期：2002-04-05 00:00:00
abstract：:Locomotor stepping elicited by lateral hypothalamic stimulation in the anesthetized rat is blocked by lesions in the anterior ventromedial midbrain. This study determined in acute experiments whether the dorsal midbrain regions implicated in locomotion were also part of the necessary pathway. Rats were anesthetized wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91049-3
更新日期：1987-01-27 00:00:00
abstract：:Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91232-7
更新日期：1994-02-21 00:00:00
abstract：:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03266-8
更新日期：2002-01-25 00:00:00
abstract：:Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01060-3
更新日期：1997-12-05 00:00:00
abstract：:The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.023
更新日期：2006-03-10 00:00:00
abstract：:Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91124-7
更新日期：1984-07-02 00:00:00
abstract：:Whole-cell voltage-clamp techniques were used to study the comparative effects of delta-9-tetrahydrocannabinol (THC) and its principal metabolite, 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), on the voltage-gated sodium current in neuroblastoma cells. The parent compound markedly depressed the inward sodium cu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91239-w
更新日期：1991-09-27 00:00:00
abstract：:The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90263-1
更新日期：1994-01-14 00:00:00
abstract：:Rd mutant mice are visually blind but they maintain the ability of synchronising their circadian rhythms to the external light-dark cycles. We used immunocytochemical procedures to detect light-induced Fos expression in the rd mice retina. We found that Fos is expressed in the rd retina in an unattenuated pattern thro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01604-2
更新日期：1999-07-10 00:00:00
abstract：:Based on the fact that several recent reports have indicated that non-immunosuppressive immunophilin ligands (IPLs) can activate neurite outgrowth or nerve regeneration, we investigated the neurotrophic factor-activating abilities of IPLs in vivo in order to clarify the molecular basis of neurotrophic-like activity. B...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02434-x
更新日期：2003-04-25 00:00:00
abstract：:Binding of cyclic AMP to the regulatory subunit of cyclic AMP-dependent protein kinase (PKA) is an essential step in cyclic AMP-mediated intracellular signal transduction. This binding is, however, rapidly inhibited in the acute phase of cerebral ischemia, indicating that the signal transduction via PKA is very vulner...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03231-0
更新日期：2002-01-04 00:00:00
abstract：:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02553-7
更新日期：2001-07-06 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
abstract：:Mechanisms of neuronal death following neuronal damage due to domoic acid are not completely defined. Bcl-2, a survival protein, protects neurons from ischemia and excitotoxin-induced damage. We previously demonstrated that Bcl-2 shuttles calcineurin to its substrates and may regulate calcium release from internal sto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.076
更新日期：2004-07-16 00:00:00
abstract：:The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.059
更新日期：2009-04-24 00:00:00
abstract：:Systemic injections of the dopamine antagonist haloperidol (0.1-2.5 mg/kg) induced a dose dependent increase in Fos-like immunoreactivity (FLI) in the internal segment of the globus pallidus (GPi) and in the substantia nigra (SN) of cynomolgus monkeys. These findings are consistent with models of basal ganglia organiz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01550-4
更新日期：1999-07-24 00:00:00
abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90142-x
更新日期：1990-11-26 00:00:00
abstract：:The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.047
更新日期：2011-02-16 00:00:00
abstract：:This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146387
更新日期：2019-11-15 00:00:00
