Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain.

abstract：:In the inferior colliculus of the mouse, 4 cell types project across the collicular commissure: small to medium sized spiny cells, small to medium sized spineless cells, medium sized sparsely spinous neurons and large cells. The axons of large cells give rise to a great number of ipsi- and contralateral collaterals te...

journal_title：Brain research

authors： González Hernández TH,Meyer G,Ferres-Torres R

更新日期：1986-03-19 00:00:00

abstract：:The newly identified neuropeptide nociceptin/orphanin FQ (NOC) was measured in different rat brain areas related to the descending anti-nociceptive pathways and compared to two opioid peptides, dynorphin B (DYN B) and Met-enkephalinArgPhe (MEAP). Two experimental models of chronic nociception, one neurogenic and one i...

journal_title：Brain research

authors： Rosén A,Lundeberg T,Bytner B,Nylander I

更新日期：2000-02-28 00:00:00

abstract：:Surgical tissue samples of the human dentate gyrus were immunostained for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA)-synthesizing enzyme, and studied by both light and electron microscopy. Immunoreactive neurons and terminals displayed similar morphological characteristics as known from studies ...

journal_title：Brain research

authors： Schlander M,Thomalske G,Frotscher M

更新日期：1987-01-13 00:00:00

abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...

journal_title：Brain research

authors： Sopp MR,Michael T,Mecklinger A

更新日期：2018-11-01 00:00:00

abstract：UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...

journal_title：Brain research

authors： Kapcala LP,De Souza EB

更新日期：1988-07-19 00:00:00

abstract：:Projection neurons from the superior colliculus (SC) to the cuneiform region (CFR) of the midbrain form distinct cell clusters in the intermediate gray layer which precisely overlap the cholinergic fiber patches in this region of the cat SC (Jeon and Mize, J. Comp. Neurol., 337 (1993) 127-150). The acetylcholine (ACh)...

journal_title：Brain research

authors： Banfro FT,Mize RR

更新日期：1996-09-16 00:00:00

abstract：:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...

journal_title：Brain research

authors： Shinoda K,Tohyama M,Shiotani Y

更新日期：1987-04-14 00:00:00

abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

journal_title：Brain research

authors： Fukuda H,Fukai K

更新日期：1986-08-20 00:00:00

abstract：:Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...

journal_title：Brain research

authors： Horvath TL,Cela V,van der Beek EM

更新日期：1998-06-08 00:00:00

abstract：:Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS by hippocampal cells. We have used o-phthaldialdehyde (OPA) derivatiz...

journal_title：Brain research

authors： Schulte MK,Roon RJ,Koerner JF

更新日期：1993-03-05 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hipp...

journal_title：Brain research

authors： Dlaboga D,Hajjhussein H,O'Donnell JM

更新日期：2006-06-22 00:00:00

abstract：:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormo...

journal_title：Brain research

authors： Giardino L,Giuliani A,Bettelli C,Calzà L

更新日期：2002-01-25 00:00:00

abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...

journal_title：Brain research

authors： Watanabe M,Sawai H,Fukuda Y

更新日期：1991-09-27 00:00:00

abstract：:Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...

journal_title：Brain research

authors： Brasileiro AD,Garcia LP,de Carvalho da Silva S,Rocha LB,Pedrosa AL,Vieira AS,da Silva VJD,Rodrigues ARA

更新日期：2019-04-01 00:00:00

abstract：:The treatment of acute and chronic pain is still deficient. The modulation of glial cells may provide novel targets to treat pain. We hypothesize that astrocytes and microglia participate in the initiation and maintenance of both, acute surgical and chronic neuropathic pain. Rats underwent paw incision, L5 nerve expos...

journal_title：Brain research

authors： Romero-Sandoval A,Chai N,Nutile-McMenemy N,Deleo JA

更新日期：2008-07-11 00:00:00

abstract：:Intrinsic membrane properties, voltage-dependent sodium and voltage-dependent potassium currents of area postrema neurons in culture have been characterized with respect to their voltage dependence, time dependence and sensitivity to specific blocking agents. The area postrema is a hindbrain circumventricular organ wh...

journal_title：Brain research

authors： Hay M,Lindsley KA

更新日期：1995-12-24 00:00:00

abstract：:The distribution of retinal ganglion cells (RGCs) providing input to the thalamofugal visual system in the pigeon was studied with an anatomical transneuronal transport technique using the fluorescent dye rhodamine beta-isothiocyanate (RITC). Unilateral injections of RITC made into the telencephalic visual Wulst resul...

journal_title：Brain research

authors： Miceli D,Repérant J,Medina M,Volle M,Rio JP

更新日期：2006-07-07 00:00:00

abstract：:The present in vitro study was performed to characterize neurons within dorsal regions of the nucleus tractus solitarii (NTS), principally at the level of area postrema, and known to receive inputs predominantly from cardiovascular and respiratory afferents (i.e. cardiorespiratory NTS). This report describes 4 classes...

journal_title：Brain research

authors： Paton JF,Foster WR,Schwaber JS

更新日期：1993-02-26 00:00:00

abstract：:Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...

journal_title：Brain research

authors： Chauhan A,Chauhan VP,Murakami N,Brockerhoff H,Wisniewski HM

更新日期：1993-11-26 00:00:00

abstract：:This study focuses on the renin-angiotensin system (RAS) in the cerebellar cortex and changes within this system after mechanically induced cerebellar injury. Using radioactive and non-radioactive in situ hybridization and immunocytochemistry angiotensinogen mRNA, angiotensinogen, angiotensin II and, for the first tim...

journal_title：Brain research

authors： Lippoldt A,Bunnemann B,Ueki A,Rosén L,Cintra A,Hasselrot U,Metzger R,Hilgenfeldt U,Brosnihan B,Ganten D

更新日期：1994-12-30 00:00:00

abstract：:We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...

journal_title：Brain research

authors： Lafon-Cazal M,Bougault I,Steinberg R,Pin JP,Bockaert J

更新日期：1992-10-09 00:00:00

abstract：:The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesenteric ganglia was depressed by bath application of Met- or Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably af...

journal_title：Brain research

authors： Jiang ZG,Simmons MA,Dun NJ

更新日期：1982-03-04 00:00:00

abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...

journal_title：Brain research

authors： Stoeckel K,Guroff G,Schwab M,Thoenen H

更新日期：1976-06-11 00:00:00

abstract：:A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...

journal_title：Brain research

authors： Yeomans JS,Cochrane KA

更新日期：1993-07-23 00:00:00

abstract：:Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(ΔE9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mic...

journal_title：Brain research

authors： Kalifa S,Polston EK,Allard JS,Manaye KF

更新日期：2011-02-28 00:00:00

abstract：:Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease...

journal_title：Brain research

authors： Tyurina YY,Kapralov AA,Jiang J,Borisenko GG,Potapovich AI,Sorokin A,Kochanek PM,Graham SH,Schor NF,Kagan VE

更新日期：2006-06-06 00:00:00

abstract：:The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in cultu...

journal_title：Brain research

authors： Manev H,Favaron M,Candeo P,Fadda E,Lipartiti M,Milani D

更新日期：1993-10-08 00:00:00

abstract：:The terminal areas and cells of origin of the projection from the dorsal column nuclei to the mesencephalon were investigated by the intra-axonal transport method. Following injection of wheat germ agglutinin-horseradish peroxidase conjugate into the dorsal column nuclei, anterograde labeling was observed in several r...

journal_title：Brain research

authors： Wiberg M,Blomqvist A

更新日期：1984-10-08 00:00:00

abstract：:The specific electrographic activity responsible for seizure-induced DNA damage remains little explored. We therefore examined the regional and temporal appearance of DNA fragmentation and cell death and its relationship to specific electrographic seizure patterns in a rat model of focally evoked limbic epilepsy. Anim...

journal_title：Brain research

authors： Henshall DC,Sinclair J,Simon RP

更新日期：2000-03-10 00:00:00

abstract：:Possible involvement of the amygdaloid input in long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses in vivo was investigated by evaluating the effects of lesions of the amygdaloid nucleus. The dentate gyrus synaptic potential evoked by low-frequency test stimulation did not ch...

journal_title：Brain research

authors： Ikegaya Y,Saito H,Abe K

更新日期：1994-09-05 00:00:00