Quisqualic acid induced sensitization and the active uptake of L-quisqualic acid by hippocampal slices.

Abstract:

:Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS by hippocampal cells. We have used o-phthaldialdehyde (OPA) derivatization and high performance liquid chromatographic (HPLC) separation of extracts from hippocampal slices which have been exposed to varied concentrations of L-QUIS to investigate L-QUIS uptake into hippocampal slices. We observe uptake rates such that the internal concentration of L-QUIS exceeds the bath concentration within 7 min. The fact that this uptake is concentrative indicates that it is mediated by an active transport system. In addition, uptake of L-QUIS may be linked to the induction of the QUIS-effect. At low concentrations of L-QUIS (< 4 microM), the QUIS-effect is only partially induced within the 4 min incubation time which maximally induces the effect when 16 microM L-QUIS is used. However, repeated 4 min exposure periods of slices to low L-QUIS concentrations will eventually induce the QUIS-effect even when each exposure is separated by extensive washout periods. Hence induction is dependent on both concentration and total exposure time. We also examined the effects of L-alpha-aminoadipic acid and L-serine-O-sulfate on the rate of L-QUIS uptake. Exposure of slices to these compounds prior to treatment with L-QUIS will block the physiological effects of L-QUIS. We found that these 'pre-blocking' compounds did not decrease the rate of L-QUIS uptake.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Brain Res

journal_title

Brain research

authors

Schulte MK,Roon RJ,Koerner JF

doi

10.1016/0006-8993(93)91359-z

subject

Has Abstract

pub_date

1993-03-05 00:00:00

pages

85-92

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91359-Z

journal_volume

605

pub_type

杂志文章
  • Cord blood administration induces oligodendrocyte survival through alterations in gene expression.

    abstract::Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.09.078

    authors: Rowe DD,Leonardo CC,Hall AA,Shahaduzzaman MD,Collier LA,Willing AE,Pennypacker KR

    更新日期:2010-12-17 00:00:00

  • Equal effects of typical environmental and specific social enrichment on posttraumatic cognitive functioning after fimbria-fornix transection in rats.

    abstract::Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.10.019

    authors: Gajhede Gram M,Gade L,Wogensen E,Mogensen J,Malá H

    更新日期:2015-12-10 00:00:00

  • Autoradiographic localization of receptors for neuropeptide FF, FLFQPQRFamide, in human spinal sensory system.

    abstract::The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostate sections from post mortem specimens of human spinal cord and lower medulla oblongata was studied by quantitative autoradiographic methods using [125I]YLFQPQRFamide as ligand. Samples were taken from five cases who had died with no hist...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91531-8

    authors: Allard M,Jordan D,Zajac JM,Ries C,Martin D,Monkouanga D,Kopp N,Simonnet G

    更新日期:1994-01-07 00:00:00

  • The alteration of glucocorticoid receptor-immunoreactivity in the rat forebrain following short-term and long-term adrenalectomy.

    abstract::To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Visser DT,Hu Z,Pasterkamp RJ,Morimoto M,Kawata M

    更新日期:1996-08-12 00:00:00

  • Spinal projections of renal afferent nerves in the rat.

    abstract::This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91292-9

    authors: Knuepfer MM,Akeyson EW,Schramm LP

    更新日期:1988-04-12 00:00:00

  • Evidence for coexistence of serotonin and noradrenaline in sympathetic nerves supplying brain vessels of guinea pig.

    abstract::Nerve fibers containing 5-hydroxytryptamine (5-HT) were demonstrated immunohistochemically in the wall of pial vessels associated with the circle of Willis in the guinea pig. The fibers formed a network structure which was more dense in the rostral part of the arterial circle and its branches than in the caudal part. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91342-x

    authors: Chang JY,Owman C,Steinbusch HW

    更新日期:1988-01-12 00:00:00

  • Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats.

    abstract::4-hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, a very important traditional Chinese medicinal herb, has been shown to be an effective agent against the central and peripheral nervous disorders. In this study, we attempted to explore the possible mechanisms unde...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.10.037

    authors: Yu SS,Zhao J,Zheng WP,Zhao Y

    更新日期:2010-01-13 00:00:00

  • Parvalbumin-positive projection neurons characterise the vocal premotor pathway in male, but not female, zebra finches.

    abstract::Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02938-9

    authors: Wild JM,Williams MN,Suthers RA

    更新日期:2001-11-02 00:00:00

  • Processing of intensity-correlated information in an acoustic-autonomic reflex system.

    abstract::The extraction and utilization of sound level changes in acoustic-autonomic reflex systems were studied on a vasoconstriction response in the tail of nonanesthetized rats. The vasoconstriction was found to depend on sound level and changes of level in the following ways. (a) It increased as a linear function of sound ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90555-7

    authors: Borg E

    更新日期:1980-04-21 00:00:00

  • Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway.

    abstract::Dexmedetomidine (Dex) has the neuroprotective effect on cerebral ischemia-reperfusion injury (CIRI). But the mechanism is not yet clear. In this study, we established a model of middle cerebral artery occlusion (MCAO) and treated primary cortical neurons with oxygen glucose deprivation (OGD), followed by Dex treatment...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.09.007

    authors: Liu C,Fu Q,Mu R,Wang F,Zhou C,Zhang L,Yu B,Zhang Y,Fang T,Tian F

    更新日期:2018-12-15 00:00:00

  • Localization of brain activity during auditory verbal short-term memory derived from magnetic recordings.

    abstract::We have studied magnetic and electrical fields of the brain in normal subjects during the performance of an auditory verbal short-term memory task. On each trial 3 digits, selected from the numbers 'one' through 'nine', were presented for memorization followed by a probe number which could or could not be a member of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90767-p

    authors: Starr A,Kristeva R,Cheyne D,Lindinger G,Deecke L

    更新日期:1991-09-06 00:00:00

  • Participation of Rel/NF-kappaB transcription factors in long-term memory in the crab Chasmagnathus.

    abstract::The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02358-6

    authors: Freudenthal R,Romano A

    更新日期:2000-02-14 00:00:00

  • Noradrenaline stimulates somatostatin release from incubated slices of the amygdala and the hypothalamic preoptic area.

    abstract::Neurotransmitter effects were studied on in vitro release of immunoreactive somatostatin (SRIF) from slices prepared from several regions of the rat brain: mediobasal hypothalamus (MBH), preoptic anterior hypothalamic area (POA) and amygdaloid complex (AMY). Potassium (K+, 56 mM) stimulated SRIF release in all structu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90523-0

    authors: Epelbaum J,Tapia-Arancibia L,Kordon C

    更新日期:1981-06-29 00:00:00

  • Facilitatory modulation of mesolimbic dopamine neuronal activity by a mu-opioid agonist and nicotine as examined with in vivo microdialysis.

    abstract::Administration of either Tyr-D-Ala-Gly-MePhe-Gly(ol) (DAGO), a mu-opioid agonist, or nicotine into the VTA (A10) caused an increase in both dopamine (DA) and its metabolite levels in both the A10 region and DA nerve terminals in the nucleus accumbens of rats when assessed with dual probe brain dialysis. These findings...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90087-4

    authors: Yoshida M,Yokoo H,Tanaka T,Mizoguchi K,Emoto H,Ishii H,Tanaka M

    更新日期:1993-10-08 00:00:00

  • Enhancement of noradrenergic neurotransmission in the nucleus of the solitary tract modulates memory storage processes.

    abstract::These studies examined whether posttraining activation of alpha1-noradrenergic receptors in the nucleus tractus solitarius (NTS) influences neural processes that are involved in encoding information into memory. Different groups of male Sprague-Dawley rats were trained in two separate learning tasks. In experiment 1, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)03323-7

    authors: Miyashita T,Williams CL

    更新日期:2003-10-17 00:00:00

  • Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia.

    abstract::A motor disorder similar to idiopathic Parkinson's Disease develops in rhesus monkeys after several daily repeated doses of N-methyl-4-phenyl, 1,2,3,6-tetrahydropyridine (MPTP). The concentrations of peptides derived from proenkephalin A, proenkephalin B, substance P and somatostatin were measured by specific radioimm...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90133-1

    authors: Zamir N,Skofitsch G,Bannon MJ,Helke CJ,Kopin IJ,Jacobowitz DM

    更新日期:1984-11-26 00:00:00

  • AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

    abstract::It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.11.019

    authors: Zhang H,Wang ZQ,Zhao DY,Zheng DM,Feng J,Song LC,Luo Y

    更新日期:2011-01-25 00:00:00

  • Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat.

    abstract::Dopamine (DA) and noradrenaline (NA) extracellular levels have been measured by microdialysis in the medial frontal cortex (MFC), nucleus accumbens (NAc) and caudate-putamen (CP) under baseline conditions in awake and halothane-anaesthetized rats, and after application of three types of stimuli which are likely to act...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90711-h

    authors: Cenci MA,Kalén P,Mandel RJ,Björklund A

    更新日期:1992-05-29 00:00:00

  • Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration.

    abstract::Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.02.021

    authors: Duckworth EA,Butler TL,De Mesquita D,Collier SN,Collier L,Pennypacker KR

    更新日期:2005-04-25 00:00:00

  • An intracellular study of synaptic transmission and dendritic morphology in sympathetic neurons of the chick embryo.

    abstract::The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90073-2

    authors: Dryer SE,Chiappinelli VA

    更新日期:1985-09-01 00:00:00

  • Neurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.

    abstract::Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03138-4

    authors: Rahner N,Holzmann C,Krüger R,Schöls L,Berger K,Riess O

    更新日期:2002-09-27 00:00:00

  • Effect of amitriptyline on glycinergic transmission in rat medullary dorsal horn neurons.

    abstract::Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.03.030

    authors: Cho JH,Choi IS,Lee MG,Jang IS

    更新日期:2012-05-21 00:00:00

  • Vasopressin reverses aluminum-induced impairment of synaptic plasticity in the rat dentate gyrus in vivo.

    abstract::Aluminum (Al), an important neurotoxin, contributes to a variety of cognitive dysfunction and mental diseases. Previous studies have demonstrated that Al impairs hippocampal long-term potentiation (LTP) in vitro and in vivo. In the present study, both LTP and LTD (long-term depression) were recorded in the same animal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02228-4

    authors: Wang M,Chen JT,Ruan DY,Xu YZ

    更新日期:2001-04-27 00:00:00

  • Audiogenic seizures evoked in DBA/2 mice induce c-fos oncogene expression into subcortical auditory nuclei.

    abstract::Recently the nuclear proto-oncogene c-fos has been shown to be rapidly and transiently expressed following seizures in many types of epilepsies. Until now, immunohistochemical as well as in situ hybridization studies have reported that the dentate gyrus of the hippocampus and most of the cortical areas were invariably...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90988-n

    authors: Le Gal La Salle G,Naquet R

    更新日期:1990-06-04 00:00:00

  • Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.

    abstract::Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.03.001

    authors: Yamamoto Y,Hosoda K,Imahori T,Tanaka J,Matsuo K,Nakai T,Irino Y,Shinohara M,Sato N,Sasayama T,Tanaka K,Nagashima H,Kohta M,Kohmura E

    更新日期:2018-05-15 00:00:00

  • Potency ratios of morphine and morphine-6beta-glucuronide analgesia elicited from the periaqueductal gray, locus coeruleus or rostral ventromedial medulla of rats.

    abstract::The present study examined whether morphine and morphine-6beta-glucuronide (M6G) analgesia on the tail-flick and jump tests differed in potency in the periaqueductal gray, the locus coeruleus or the rostral ventromedial medulla. Morphine and M6G significantly and dose-dependently elicited analgesia on both nociceptive...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00520-4

    authors: Krzanowska EK,Rossi GC,Pasternak GW,Bodnar RJ

    更新日期:1998-07-20 00:00:00

  • Short internodal lengths of canine tooth pulp axons in the young adult cat.

    abstract::Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90221-x

    authors: Fried K,Erdélyi G

    更新日期:1984-06-11 00:00:00

  • The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.

    abstract::The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91604-q

    authors: Janusz CA,Berman RF

    更新日期:1993-08-13 00:00:00

  • Blocking GABAA neurotransmission in the interposed nuclei: effects on conditioned and unconditioned eyeblinks.

    abstract::The interposed nuclei (IN) of the intermediate cerebellum are critical components of the circuits that control associative learning of eyeblinks and other defensive reflexes in mammals. The IN, which represent the sole output of the intermediate cerebellum, receive massive GABAergic input from Purkinje cells of the ce...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.07.053

    authors: Parker KL,Zbarska S,Carrel AJ,Bracha V

    更新日期:2009-10-06 00:00:00

  • Temporal correlation of graded reversible inspiratory inhibition with discharge patterns of late inspiratory neurons located in the dorsal respiratory group in cats.

    abstract::Respiratory neurons were recorded with microelectrodes in the medullary dorsal respiratory group of pentobarbital-anesthetized cats. The animals were ventilated with a phrenic-driven servorespirator that allowed manipulation of phasic volume feedback. By increasing or decreasing the gain of the servorespirator, graded...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90924-5

    authors: Baker JP Jr,Remmers JE

    更新日期:1980-11-03 00:00:00