Abstract：
:The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmission is mediated by at least 3-5 convergent preganglionic inputs and can be detected at the earliest embryonic stage examined (Stage 38; 12 days of incubation). Two types of non-cholinergic slow EPSPs have been observed and distinguished by their time course and the resulting changes in input resistance. One of these slow synaptic potentials is mimicked by exogenously applied substance P, but not by exogenous luteinizing hormone-releasing hormone (LH-RH). Muscarinic agonists also evoke slow depolarizations in the ganglia, mediated at least in part by inhibition of the M-current. Intracellular labeling with horseradish peroxidase reveals cells with 5-10 primary dendrites at Stage 42 (16 days of incubation), the earliest stage to exhibit slow EPSPs. The active and passive membrane properties of avian sympathetic neurons, including the presence of the M-current, generally resemble those of adult mammalian and amphibian sympathetic neurons. Functional activity in chick sympathetic neurons is present at a developmental stage where both biochemical and morphological indices of synapse maturation are at low levels. Since this progression has also been observed in the avian ciliary ganglion, it may be of general relevance to neuronal development.
journal_name
Brain Resjournal_title
Brain researchauthors
Dryer SE,Chiappinelli VAdoi
10.1016/0165-3806(85)90073-2subject
Has Abstractpub_date
1985-09-01 00:00:00pages
99-111issue
1eissn
0006-8993issn
1872-6240journal_volume
354pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02797-5
更新日期：2003-07-04 00:00:00
abstract：:Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00822-8
更新日期：1995-10-02 00:00:00
abstract：:Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01364-n
更新日期：1995-02-13 00:00:00
abstract：:Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.068
更新日期：2011-08-02 00:00:00
abstract：:Primary cultures of the 21 day foetal rat brain contain a cohort of astroblasts that concertedly acquire glial fibrillary acidic protein (GFAP) filaments between the 16th and 18th hour after plating. This burst of cytoskeletal differentiation is not observed in cultures initiated from the 18 day foetal brain and is no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90637-7
更新日期：1985-07-22 00:00:00
abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90249-3
更新日期：1976-10-29 00:00:00
abstract：:Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.049
更新日期：2009-06-01 00:00:00
abstract：:Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02542-3
更新日期：2003-06-13 00:00:00
abstract：:Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02361-2
更新日期：2002-04-26 00:00:00
abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03766-6
更新日期：2003-04-18 00:00:00
abstract：:Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90284-0
更新日期：1982-01-28 00:00:00
abstract：:Dipiperidinoethane (DPE) administration produces seizures and CNS lesions. Here we elucidate the cholinergic origin of DPE toxicity. DPE is both an acetylcholinesterase (AChE) inhibitor and a muscarinic antagonist. This dual action negates most of the toxic effects of the compound in vivo. The neurotoxicity is believe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90728-0
更新日期：1985-04-01 00:00:00
abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90244-7
更新日期：1987-09-08 00:00:00
abstract：:Parkinson's disease (PD) is caused by oxidative stress, and erythropoietin (EPO) reduces oxidative stress in the brain. However, EPO cannot be developed as a treatment for PD, because EPO does not cross the blood-brain barrier (BBB). A brain penetrating form of human EPO has been developed wherein EPO is fused to a ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.061
更新日期：2011-03-25 00:00:00
abstract：:The aim of the present study was to elucidate the effects of granulocyte colony-stimulating factor (G-CSF)-mediated mobilization of bone marrow-derived stem cells on the injured spinal cord. Bone marrow cells of green fluorescent protein (GFP) transgenic mice were transplanted into lethally irradiated C57BL/6 mice. Fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.058
更新日期：2007-05-29 00:00:00
abstract：:Following extirpation of three quarters of the eye anlage of Xenopus laevis in stage 33/34, the remaining quadrants developed into small eyes of normal shape. Irrespective of the different portions of the eye anlage the quarter eyes originated from, the retinotectal projection was always confined to the rostrolateral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90089-1
更新日期：1986-09-01 00:00:00
abstract：:The effects of retinoic acid (RA), a naturally occurring metabolite of vitamin A, on the growth, morphology and neurochemical differentiation of the PC12 clone of rat pheochromocytoma cells were investigated. RA added to the medium inhibited the growth of PC12 cells in a dose-dependent manner up to 10 microM without a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90460-5
更新日期：1989-11-13 00:00:00
abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02657-3
更新日期：2000-09-08 00:00:00
abstract：:Lithium is detected in the mouse brain with the aid of a (n,alpha) nuclear reaction. The resolving power is of a few micron. The detection efficiency is estimated in a first series of experiments with brain sections of progressively increasing thickness. This allows us to make the microlocation of lithium in the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90239-5
更新日期：1980-10-13 00:00:00
abstract：:The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.11.062
更新日期：2012-01-30 00:00:00
abstract：:Bilateral lesions of the amygdaloid complex in C57BL/6 mice prevented the occurrence of morphine-induced hypermotility (running fit). This effect, that was different from that observed after hippocampal lesions but similar to that observed after caudate lesions, confirms the role of the basal ganglia catecholaminergic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91328-0
更新日期：1989-02-06 00:00:00
abstract：:The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90029-8
更新日期：1981-11-01 00:00:00
abstract：:EEG power spectra exhibit site-specific and state-related differences in specific frequency bands. In the present study we investigated the effect of total sleep deprivation on sleep EEG topography. Eight healthy, young, right-handed subjects were recorded during baseline sleep and recovery sleep after sleep deprivati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02796-2
更新日期：2001-09-21 00:00:00
abstract：:To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices. As a model of in vivo ischemia we used a state of both glucose and oxyge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90242-4
更新日期：1990-08-27 00:00:00
abstract：:Binding of cyclic AMP to the regulatory subunit of cyclic AMP-dependent protein kinase (PKA) is an essential step in cyclic AMP-mediated intracellular signal transduction. This binding is, however, rapidly inhibited in the acute phase of cerebral ischemia, indicating that the signal transduction via PKA is very vulner...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03231-0
更新日期：2002-01-04 00:00:00
abstract：:The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90239-8
更新日期：1990-03-12 00:00:00
abstract：:Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01029-3
更新日期：1996-12-16 00:00:00
abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90598-7
更新日期：1988-10-11 00:00:00
abstract：:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90353-8
更新日期：1988-07-19 00:00:00
abstract：:We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02644-6
更新日期：2002-06-28 00:00:00
